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Avenu Medical Inc. has been issued a patent for a percutaneous anastomotic device that creates a native vessel bypass, offering a less invasive and more cost-effective alternative to traditional vascular surgical techniques. The device aims to restore blood flow to extremities in patients with total occlusions of the artery, particularly those suffering from Critical Limb Ischemia. The method involves inserting a needle into the vein and artery, creating an anastomosis between the two vessels, and disabling venous valves to allow retrograde venous flow of arterial blood. [Extracted from the article]

A study conducted at Medical University Lublin in Poland focused on identifying spectroscopy markers of atherosclerotic carotid stenosis (ACS) using FTIR-ATR combined with machine learning and chemometrics analyses. The research aimed to develop new methods for diagnosing ACS and determining patient eligibility for surgery. Results showed promising accuracy rates above 90%, suggesting that FTIR-ATR could serve as an additional diagnostic tool for ACS qualification. The study highlights the potential of emerging technologies like machine learning in improving cardiovascular disease diagnostics and treatment. [Extracted from the article]

A recent study conducted at Tianjin Huanhu Hospital in China explored the use of high-resolution magnetic imaging (HR-MRI) in guiding the perioperative management of acute intracranial large artery occlusion during mechanical thrombectomy. The retrospective analysis of patient data showed promising outcomes, with 19 out of 22 patients achieving successful recanalization. The use of HR-MRI was found to enhance the assessment of mechanical thrombectomy procedures, aiding in lesion characterization and vessel relationship identification. The research concluded that this approach could lead to safer and more effective emergency thrombectomy procedures. [Extracted from the article]

A recent study conducted at Thomas Jefferson University Hospital compared the outcomes of unilateral and bilateral revascularization in Moyamoya disease. The study included 497 patients from 13 academic institutions and found that while bilateral revascularization was associated with more perioperative asymptomatic strokes and higher rates of excellent functional outcomes, there were no significant differences between the two approaches in terms of overall outcomes. The researchers concluded that further prospective studies are needed to validate these results. [Extracted from the article]

A recent report from the Edith Wolfson Medical Center discusses the impact of immune checkpoint inhibitors (ICIs) on atherosclerosis. The study focused on CD8+ T-cells and evaluated the effects of statins and PCSK9 inhibitors on atherosclerosis under ICIs treatment in mice. The research found that statins and PCSK9 inhibitors could prevent CD8+ T cell infiltration in arterial walls induced by anti-PD-1 treatment. This study suggests the potential benefits of PCSK9 inhibitor treatment in preventing arterial inflammation and enhancing anti-tumor immune responses under ICIs treatment. [Extracted from the article]

A recent study published in the Journal of Exploratory Research in Pharmacology investigated the effects of taurine supplementation on atherosclerotic plaque development. The study found that taurine treatment reduced plaque areas in mice and increased the stability of atherosclerotic plaques. However, caution is advised in using dietary taurine supplements due to potential risks associated with energy drinks containing taurine. Plasma taurine levels were also found to be higher in patients with acute myocardial infarction compared to healthy individuals. [Extracted from the article]

A recent study conducted at Dr. Rajendra Prasad Government Medical College in India focused on lipid-lowering therapy (LLT) and the unmet targets in Indian patients with coronary artery disease (CAD). The study found that only 25.9% of patients achieved the recommended LDL-C goal of <50 mg/dl, with a high prevalence of diabetes, hypertension, and obesity among the participants. The researchers concluded that greater utilization of combination LLT, including high-intensity statins and non-statin LLT, may be necessary to improve outcomes for high-risk patients. [Extracted from the article]

A study conducted at the First Affiliated Hospital in Bengbu, People's Republic of China, focused on the impact of the FOCUS-PDCA procedure on reducing complications after transradial interventional therapy (TRI) in cardiology and angiology. The research found that the FOCUS-PDCA approach led to a significant decrease in postoperative pain, swelling, and improved patient comfort compared to the control group. The results suggest that the FOCUS-PDCA method may be beneficial in reducing early pain and long-term swelling after TRI, enhancing patient comfort, and improving specialist care quality. The study was peer-reviewed and may have implications for future medical practices. [Extracted from the article]

A study from the National University of Singapore explores the role of ceramides in atherosclerosis, a leading cause of cardiovascular disease. Researchers found that inhibiting ceramide de novo synthesis with myriocin nanoparticles reduced plaque vulnerability and inflammation in mice models. This approach shows promise in mitigating atherosclerosis progression and improving plaque stability, offering a potential therapeutic intervention for cardiovascular health. [Extracted from the article]

Researchers at Isfahan University of Medical Sciences discussed a successful case of intervention for traumatic central retinal artery occlusion (CRAO) in a 47-year-old woman with controlled comorbidities. The patient experienced significant ischemic damage following a traumatic injury, but her visual acuity improved from 2/10 to 10/10 with intervention. The case highlights the importance of early recognition and intervention in managing traumatic CRAO to prevent irreversible retinal damage and the need for enhanced diagnostic and therapeutic strategies as understanding of the condition's pathophysiology advances. [Extracted from the article]

Researchers at Hunan University of Chinese Medicine have conducted a study on the role of copper homeostasis in atherosclerosis, a chronic inflammatory condition that contributes to cardiovascular disease. The study highlights the importance of maintaining normal copper levels for cardiovascular health and explores how disruptions in copper balance can lead to cell death, known as "cuproptosis," which is linked to atherosclerosis. The research also discusses potential therapeutic approaches, such as copper balance regulators and nanotechnology interventions, for preventing and treating cardiovascular disease. For more information, the full article can be accessed in the International Journal of Molecular Sciences. [Extracted from the article]

A study conducted by researchers at Shahid Beheshti University of Medical Sciences focused on the trajectories of lipid profiles during adolescence and their impact on subclinical atherosclerosis in early adulthood. The study, which included 1006 participants, found that unfavorable changes in lipid parameters were significantly associated with higher carotid intima-media thickness (cIMT) values, highlighting the importance of monitoring lipid levels from early adolescence. The findings suggest that early-life lipid profile trajectories may play a crucial role in the development of cardiovascular diseases in young adults. [Extracted from the article]

A recent study conducted at Tangshan Gongren Hospital investigated the risk factors associated with carotid plaque in asymptomatic adults over 40 years old. The study found that age, fasting blood glucose, total cholesterol, homocysteine levels, and male gender were identified as risk factors for carotid atherosclerosis. The research highlighted the importance of gender differences in carotid atherosclerosis and suggested further attention to this area. The findings were published in BMC Cardiovascular Disorders and are available for further exploration. [Extracted from the article]

A recent study conducted by researchers at the Medical University of Vienna focused on the prevalence and incidence of chronic wounds in Austria. The study utilized real-world data from an outpatient wound center and the Austrian Health Insurance Fund to analyze patient characteristics and estimate rates of chronic wounds broken down by age group, gender, and region. The preliminary results indicated that chronic wound patients tend to be older and have multiple health conditions, with gender differences observed in the occurrence of comorbidities. This research contributes valuable information for healthcare planning and health economic assessments related to chronic wounds. [Extracted from the article]

The article discusses research on the association between psychosocial health and cerebral small vessel disease markers with dementia risk in older adults. The study, conducted by the National Institute of Neurological Disorders and Stroke, found that mid-life social relationships significantly modified the association between white matter hyperintensity volume and dementia risk. Participants with strong mid-life social relationships showed a reduced risk of dementia associated with cerebral small vessel disease. The research suggests the need for further studies to evaluate psychosocial health throughout life and its impact on the relationship between cerebral small vessel disease and dementia. [Extracted from the article]

The article discusses the use of joint longitudinal and time-to-event models to improve the parameterization of chronic disease microsimulation models, focusing on cardiovascular disease (CVD) as a case study. By comparing different parameterization approaches, the study found that the joint model approach produced more accurate predictions of CVD incidence based on observed data. This method could enhance the reliability of microsimulation models, particularly for policies that require tracking dynamic risk factors over time. Further research is needed to determine the specific circumstances where the joint model approach is most effective. [Extracted from the article]

A recent study conducted by the University of California San Diego (UCSD) examined the relationship between regular cannabis use and blood pressure in older adults. The research, which analyzed data from the Multi-Ethnic Study of Atherosclerosis, found no significant association between regular cannabis smoking and increased blood pressure or hypertension in older adults. The study included a diverse group of participants and concluded that there was no evidence of increased risk for hypertension or blood pressure due to regular cannabis smoking. [Extracted from the article]

A recent study conducted at the University of Maryland focused on the impact of Spironolactone therapy on atherosclerosis in Type 2 diabetics with chronic kidney disease. The study utilized a multi-omics approach to identify molecular mechanisms of benefit, revealing downregulation of inflammatory and profibrotic pathways with Spironolactone treatment. The findings suggest potential targeted interventions for atherosclerosis treatment. The research was published in the European Heart Journal and can be accessed for further information. [Extracted from the article]

A study conducted at Technical University Munich (TU Munich) examined the impact of successful recanalization on outcomes in patients with basilar artery occlusion. The research found that underlying basilar stenosis reduces the effectiveness of successful recanalization in improving overall outcomes. The study included 210 patients and highlighted the importance of successful recanalization in preventing poor outcomes in basilar artery occlusion cases. For more information, the full article can be accessed for free at https://doi.org/10.3390/diagnostics14212348. [Extracted from the article]

A recent study from Uppsala University examined the association between cardiovascular risk and the presence of coronary atherosclerosis using Coronary Computed Tomography Angiography (CCTA). The research identified individuals with unexpected absence or severe subclinical coronary atherosclerosis despite their estimated cardiovascular risk levels. Factors such as age, gender, smoking history, and metabolic health were found to influence the presence or absence of coronary calcifications in individuals with varying cardiovascular risk profiles. Further research is needed to understand the mechanisms behind these unexpected findings. [Extracted from the article]

Recent research from Xiyuan Hospital in Beijing, China, explores the potential of a combination of tetramethylpyrazine (TMP) and paeoniflorin (PF) in alleviating atherosclerosis. The study conducted on ApoE-/- mice showed that TMP-PF reduced hyperlipemia, inhibited plaque angiogenesis, and decreased atherosclerosis progression. The findings suggest that TMP-PF may have a positive impact on reducing hyperlipemia and attenuating the development of atherosclerosis. [Extracted from the article]

A recent report from Guangdong Medical University in Dongguan, People's Republic of China, discusses the importance of early diagnosis and treatment strategies for atherosclerosis (AS) due to its insidious onset and potential for fatal cardiovascular events. The study focuses on the development of activatable fluorescent probes based on the atherosclerotic microenvironment for precise identification and treatment of AS. The researchers highlight the correlation between structural changes and fluorescence signal alterations in these probes, emphasizing their potential for innovative imaging-guided therapy. For more information, the full article can be accessed in iScience, and inquiries can be directed to the authors at Guangdong Medical University. [Extracted from the article]

Researchers from the Fraunhofer-Institute for Applied Polymer Research conducted a study on the effects of Arthrospira platensis (AP) on human umbilical vein endothelial cells to understand atherosclerosis better. The study found that AP increased cell proliferation without causing inflammation, promoting an antithrombotic state. This research suggests that AP could potentially be used to accelerate endothelial cell proliferation in conditions like atherosclerosis or after stent placement. For more information, the study can be found in Life journal, volume 14, issue 10. [Extracted from the article]

A recent study conducted by the National Institute of Environmental Health Sciences focused on the genetic determinants of hemoglobin glycation index (HGI), a biomarker for diabetes complications. The study, which included a genome-wide association analysis, identified specific genetic variants associated with HGI, showing significant heritability and differences by sex and race. The findings suggest that HGI may serve as a distinct biomarker for diabetes complications, separate from traditional markers like fasting plasma glucose or HbA1c. For more information, the full article can be accessed through Frontiers in Endocrinology. [Extracted from the article]

Researchers at Erasmus University Medical Center have highlighted new data on metabolic syndrome, specifically focusing on the cardiovascular-kidney-metabolic (CKM) syndrome construct. The study aimed to characterize the distribution of subclinical atherosclerosis and quantify long-term cardiovascular disease (CVD) risk associated with CKM Stage 3 in adults without prior CVD. Results showed that adults in CKM Stage 3 had a significantly higher risk for CVD compared to those in lower CKM stages, emphasizing the importance of addressing cardiovascular, kidney, and metabolic risk factors for prevention of CVD. The study provides valuable insights into understanding and managing high-risk individuals with metabolic syndrome. [Extracted from the article]

A recent study conducted by researchers at the University of California San Diego (UCSD) examined the relationship between regular cannabis smoking and carotid artery calcification in a diverse group of older adults. The study found no significant associations between regular cannabis smoking and the prevalence or extent of calcified plaque in the carotid arteries, except for a slightly higher prevalence in men. The research, published in Vascular Medicine, contributes to the ongoing discussion on the potential cardiovascular effects of cannabis use. [Extracted from the article]

Researchers from the University of Pisa conducted a study on atrial fibrillation (AF) using a machine learning approach to predict the condition. The study included participants from the Atherosclerosis Risk in Communities (ARIC) Study and found that incorporating left atrial (LA) function parameters in the model outperformed traditional risk scores in predicting AF. The research suggests that assessing LA function may help clinicians better understand individual risk factors for AF. The study was published in the European Heart Journal and can be accessed for free online. [Extracted from the article]

Recent research from Huazhong Agricultural University in Wuhan, China, explores the potential of combining oligomeric procyanidins with Parabacteroides distasonis to ameliorate high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation, and bile acid metabolism in mice. The study, supported by the National Natural Science Foundation of China, suggests that this combination treatment significantly decreased atherosclerotic lesions and improved lipid metabolism, inflammation, and oxidative stress in the mice. The findings provide new insights into developing anti-atherosclerotic strategies using probiotics and prebiotics to prevent atherosclerosis. [Extracted from the article]

A study conducted by researchers at the Mailman School of Public Health examined racial disparities in incident and recurrent cardiovascular events among participants in the Multi-Ethnic Study of Atherosclerosis. The study found that Black participants had lower or similar rates of incident and recurrent cardiovascular events compared to White participants, but higher rates of fatal cardiovascular events. Additionally, Black participants had lower rates of revascularization compared to White participants. This research sheds light on the importance of understanding and addressing racial disparities in cardiovascular health outcomes. [Extracted from the article]

A recent study conducted at the National Research Center for Preventive Medicine in Moscow, Russia, explored the role of placental cadherin (CDH3) in atherosclerosis. The study found that serum CDH3 levels were associated with the severity of atherosclerosis and diastolic blood pressure, and could predict cardiovascular outcomes after a 3-year follow-up. The research suggests that CDH3 may play a role in plaque biology and could be a novel predictor of cardiovascular events related to atherosclerosis. [Extracted from the article]

A research report from Wenzhou Medical University in the People's Republic of China discusses the causes of retinal arterial microaneurysm combined with branch retinal artery occlusion. The study found that complications during photocoagulation therapy, intraretinal hemorrhage, and embolus dislodgement can lead to these conditions, which can cause acute vision loss. The research emphasizes the importance of ophthalmologists paying attention not only to the patient's fundus but also to systemic diseases. [Extracted from the article]

A study conducted at the University Hospital Basel examined the attainment of low-density lipoprotein cholesterol (LDL-C) guideline target levels in patients with a history of atherothrombosis, atherosclerosis, and those in primary prevention. The research found that LDL-C levels were higher and guideline target value attainment was worse in women compared to men in all three groups. Additionally, within the secondary prevention group, individuals with a previous atherothrombotic event had lower LDL-C levels and higher guideline target value attainment. The study highlights sex-specific differences in LDL-C control and the impact of previous cardiovascular events on cholesterol levels. [Extracted from the article]

Researchers from Toyo University conducted a study on the effects of short-term intake of Delta-tocotrienol (8-T3) on lipid profiles in healthy individuals. The study found that plasma T3 concentrations increased significantly with T3 intake, and while T3 did not significantly affect lipid profiles, it tended to increase HDL-C levels. The research suggests the potential of T3 for preventing atherosclerosis in young people. This study was funded by various organizations and has been peer-reviewed. [Extracted from the article]

A recent study conducted at the University of Michigan Medical Center focused on the role of Kruppel-like factor 11 (KLF11) in diabetic atherosclerosis. The research found that endothelial KLF11 deficiency accelerates atherogenesis under diabetic conditions, while KLF11 overexpression inhibits it. The study suggests that manipulating KLF11 could be a promising approach for developing novel therapies for diabetes-related cardiovascular complications. For more information, the full article can be accessed in Cardiovascular Diabetology. [Extracted from the article]

A study conducted at Nanchang University in the People's Republic of China compared imaging features and stroke-related factors between posterior circulation atherosclerosis and intramural hematoma-type dissection. The research found that patients with intramural hematoma-type dissection were younger, had lower prevalence of certain risk factors, and exhibited different imaging features compared to those with atherosclerosis. The study concluded that arterial remodeling capacity was closely linked to stroke risk, highlighting the importance of understanding these factors in clinical practice. [Extracted from the article]

A recent study conducted at Royal Brompton Hospital examined the relationship between body mass index (BMI) and major adverse cardiovascular events in patients with diabetes and stable coronary artery disease. The study, which included over 19,000 individuals, found that BMI was associated with hospitalization for heart failure and serious adverse events, but not with other efficacy or safety outcomes. The research concluded that ticagrelor was equally beneficial across all BMI ranges for patients with stable CAD and type 2 diabetes. [Extracted from the article]

A recent study conducted at Aarhus University Hospital examined the impact of coronary artery disease (CAD) and left ventricular ejection fraction (LVEF) on mortality following a first-time non-ST-segment elevation myocardial infarction (NSTEMI). The research found that decreasing LVEF was more strongly associated with 5-year mortality than the extent of CAD. The study included 8,770 patients with first-time NSTEMI and obstructive CAD, revealing a gradual increase in mortality with declining LVEF and increasing CAD extent. The findings suggest that LVEF reduction plays a significant role in predicting mortality outcomes in NSTEMI patients. [Extracted from the article]

Researchers at the Kolling Institute in Sydney, Australia, have conducted a study on the expression of Myeloperoxidase (MPO) in patient-derived endothelial colony-forming cells (ECFCs) and its potential associations with coronary artery disease (CAD) and mitochondrial function. The study found that MPO was present in the nucleus of ECFCs, with different implications for non-CAD and CAD patients. Non-CAD patients with MPO expression showed upregulated mitochondrial-antioxidant genes, while CAD patients with MPO gene expression had greater mitochondrial dysfunction. The research sheds light on the role of MPO in cardiovascular diseases and mitochondrial function. [Extracted from the article]

A recent study conducted at the University of Texas Health Science Center in Houston explored the benefits of prophylactic carotid revascularization in patients with asymptomatic carotid artery stenosis undergoing coronary artery bypass surgery. The research highlighted the increased risk of perioperative stroke in patients undergoing CABG and emphasized the importance of individualized approaches and careful consideration of patient risk factors in determining the need for carotid screening and revascularization before surgery. The study suggested that carotid duplex sonography could be used as an initial screening tool, and that synchronous surgery may be safer than staged procedures for patients with advanced carotid atherosclerosis. [Extracted from the article]

Research conducted at Sheffield Teaching Hospitals NHS Foundation Trust focused on the use of myocardial perfusion scintigraphy (MPS) to screen for asymptomatic coronary artery disease (CAD) in individuals undergoing kidney transplantation. The study found that while MPS identified a small number of individuals requiring intervention for CAD, it also significantly delayed transplant decisions, with an average delay of 1.5 years. The researchers suggested that transplant centers should reevaluate their use of cardiovascular disease screening protocols prior to listing individuals for transplantation. [Extracted from the article]

A recent study conducted at Sassari University Hospital explored the causal relationship between visceral fat and coronary artery disease (CAD) using Mendelian randomization analysis. The research, which included data from over 500,000 participants, revealed a significant genetic association between increased levels of visceral fat and the risk of CAD, independent of body mass index (BMI). The findings suggest that visceral fat may represent a significant, independent risk factor for CAD, highlighting the importance of comprehensive lipid management in cardiovascular risk reduction strategies. Further research is needed to investigate potential mechanisms and therapeutic targets related to visceral fat in the context of cardiovascular disease. [Extracted from the article]

A study conducted by researchers at Jiangsu University in China explored the potential relationship between antihypertensive drugs and Hashimoto's thyroiditis (HT), an autoimmune disease. Using a drug-target Mendelian randomization approach, the study found that calcium channel blockers (CCBs) and diuretics may reduce the risk of HT in both European and Asian populations. The researchers suggest that further research is needed to determine if antihypertensive medications could be repurposed for the prevention of HT. [Extracted from the article]

A study conducted at Turku University Hospital examined the prognostic value of anatomical and functional measures of coronary artery disease (CAD) in diabetic and non-diabetic patients. The research found that patients with diabetes had more advanced CAD and higher rates of adverse events compared to non-diabetic patients. While anatomical findings predicted outcomes in both groups, functional imaging was more effective in risk stratifying non-diabetic patients, suggesting that diabetic patients had impaired long-term outcomes regardless of perfusion findings. [Extracted from the article]

New research from University College London (UCL) explores the relationship between genetic and lifestyle factors in coronary artery disease (CAD) and the risk of incident dementia. The study, conducted on 457,353 participants, found that a higher genetic risk for CAD was associated with an increased risk of developing all-cause dementia, Alzheimer's disease, and vascular dementia. The research suggests that lifestyle interventions aimed at reducing CAD risk may also lower the risk of developing dementia, particularly in individuals with underlying vascular pathology. [Extracted from the article]

A recent study conducted at the University of Hong Kong focused on the clinical value of computational angiography-derived fractional flow reserve (caFFR) in patients with stable coronary artery disease. The research, which included 1308 patients and 3329 vessels, found that per-vessel prognostic value of caFFR was associated with lower risks of vessel-related cardiovascular events. The study concluded that adhering to caFFR guidelines could lead to a reduced risk of adverse cardiovascular outcomes. For more information, readers can refer to the Journal of Cardiovascular Translational Research. [Extracted from the article]

A recent study conducted by researchers at Imperial College London explored the use of Fractional Flow Reserve (FFR) and Instantaneous Wave-Free Ratio (iFR) in predicting the response to Percutaneous Coronary Intervention (PCI) in patients with stable coronary artery disease. The study found that lower FFR and iFR values were associated with greater placebo-controlled improvement in angina symptoms with PCI. This research suggests that invasive coronary physiology measurements can help identify patients who are most likely to benefit from PCI. The study was funded by various organizations including the Nihr Biomedical Research Centre and the British Heart Foundation. [Extracted from the article]

A recent study from the Medical University of Vienna suggests that liver fibrosis may be an indicator of elevated risk in patients with coronary artery disease (CAD). The study used the FIB-4 score to detect liver fibrosis, which was found to be associated with higher mortality rates in CAD patients. The research highlights the potential of using the FIB-4 score to predict mortality in CAD populations, even in those without clinical signs of liver dysfunction. [Extracted from the article]

A recent study conducted by a Research Unit focused on heart disease compared the effectiveness of traditional risk scores, calcium scores, and genetic risk scores in predicting and discriminating cardiovascular events in an asymptomatic Portuguese population. The study found that the coronary artery calcium score (CACS) was the most effective in identifying high-risk individuals and those with subclinical atherosclerosis, potentially improving cardiovascular risk management strategies. The research suggests that the CACS, as a marker of disease in the vessel wall, may be a valuable tool in preventing future cardiovascular events. [Extracted from the article]

A recent study conducted at Matsunami General Hospital compared the long-term prognosis of coronary artery disease (CAD) and peripheral artery disease (PAD) in patients undergoing cardiovascular bypass surgery, with a focus on hemodialysis (HD) and non-HD patients. The study found that HD patients consistently had a higher risk of mortality after surgery compared to non-HD patients, with PAD patients showing a higher mortality risk than CAD patients in this high-risk population. The research suggests that PAD may indicate a more advanced atherosclerotic status than CAD in these patients. For more information, the study can be accessed in the European Heart Journal. [Extracted from the article]

A recent study conducted at Aberdeen Royal Infirmary focused on the prevalence, characteristics, and significance of anomalous coronary arteries in adults undergoing cardiac CT scans. The research found that 1.45% of patients had anomalous coronary arteries, with the most common anomaly being the left circumflex artery arising from the right side. The study concluded that most coronary artery anomalies are incidental findings and can be managed conservatively. For more information, the full article can be accessed for free at the European Heart Journal website. [Extracted from the article]