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A recent study from Shandong University in China focused on paraneoplastic cerebellar degeneration (PCD) associated with anti-Yo antibodies, a rare immune-mediated neurological syndrome. The case report highlighted successful treatment with ofatumumab therapy after initial challenges with traditional treatments. The research underscores the complexity of diagnosing and managing PCD, offering insights into potential therapeutic approaches for this condition. [Extracted from the article]

A recent study from the Department of Neurology reported a case of a 57-year-old Chinese female with anti-IgLON5 disease combined with paraneoplastic cerebellar degeneration. The patient presented with walking unsteadily and logagnosia, with a history of breast cancer. The study highlights the importance of considering anti-IgLON5 disease and PCD as differential diagnoses in cases of meningoencephalitis that do not respond to conventional treatment. [Extracted from the article]

A recent study conducted at the University of California Berkeley explored the impact of cerebellar degeneration on strategy discovery and recall in visuomotor adaptation tasks. The research found that individuals with cerebellar degeneration were slower to derive an appropriate aiming strategy initially but exhibited similar recall of the strategy later on. This study sheds light on the complex role of the cerebellum in sensorimotor learning processes. Financial support for this research was provided by the NIH National Institute of Neurological Disorders & Stroke (NINDS). [Extracted from the article]

Researchers at the University of Tokyo recently reported new findings on Paraneoplastic Cerebellar Degeneration, a condition linked to certain cancers. The study highlighted a case of a 77-year-old woman with ataxia and anti-Yo antibodies, leading to the early diagnosis of peritoneal serous papillary carcinoma. The researchers emphasized the importance of considering this rare gynecologic cancer in cases of PCD with anti-Yo antibodies for prompt diagnosis and treatment. The study has been peer-reviewed and provides valuable insights into the relationship between neurological conditions and cancer. [Extracted from the article]

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences have discovered that long-term memories for motor skills, such as riding a bike, are formed in the cerebellum. This finding sheds light on the distinct regions of the brain responsible for short- and long-term sensorimotor memories. The study highlights the critical role of the cerebellum in forming stable memories for motor skills, independent of short-term memory systems. [Extracted from the article]

A recent study investigated the effects of motor training on the cortico-cerebellar network in individuals with cerebellar degeneration. The study found that patients with cerebellar degeneration had impaired connectivity between cerebellar motor regions and neocortical visuomotor and premotor regions compared to healthy controls. However, after a five-day forearm movement training, participants in both groups showed enhanced connectivity in the cortico-cerebellar visuomotor network. Additionally, patients who received explicit verbal feedback during training exhibited improved connectivity between a cerebellar cognitive region and the dorsolateral prefrontal cortex. These findings suggest that motor training can improve functional connectivity in the cortico-cerebellar network in individuals with cerebellar degeneration. [Extracted from the article]

A recent study investigated the effects of motor training on the cortico-cerebellar network in patients with cerebellar degeneration. The study found that patients with cerebellar degeneration showed impaired connectivity between cerebellar motor regions and neocortical visuomotor and premotor regions compared to healthy controls. However, after a five-day forearm movement training, patients exhibited enhanced connectivity in the cortico-cerebellar visuomotor network, particularly in the contralateral side of the trained arm. Additionally, training with explicit verbal feedback improved connectivity between a cerebellar cognitive region and the dorsolateral prefrontal cortex. These findings suggest that motor training can improve functional connectivity in the cortico-cerebellar network in patients with cerebellar degeneration. [Extracted from the article]

A recent study conducted by researchers at the University of Sheffield in the United Kingdom has shed light on the neuropathological basis of gluten ataxia, a neurological manifestation of gluten sensitivity. The study found that severe cerebellar atrophy, lymphocytic infiltration, and microglial immune activation are key features of gluten ataxia. These findings suggest that both cellular and humoral immune-mediated processes contribute to the development of gluten ataxia. This research provides valuable insights into the understanding and potential treatment of this condition. [Extracted from the article]

A report from the University of Palermo in Italy discusses paraneoplastic cerebellar degeneration, a rare complication of cancer that affects the nervous system. The report highlights the importance of early recognition and diagnosis of this condition, as it can precede the clinical manifestations of cancer. The researchers emphasize that specific antibodies can aid in diagnosis, although they are not always detectable. The case study presented in the report focuses on a young female with paraneoplastic cerebellar degeneration associated with breast cancer. [Extracted from the article]

A recent study conducted by researchers at the Moss Rehabilitation Research Institute explores the relationship between reinforcement motor learning and state estimation in individuals with cerebellar degeneration. The study found that the integrity of sensory prediction is a strong predictor of reinforcement motor learning after cerebellar damage. The research suggests that cerebellum-dependent sensory prediction may contribute to reinforcement learning in motor contexts by enhancing body state estimates. The findings highlight the importance of understanding the factors underlying inter-individual variability in learning. [Extracted from the article]

All three patients had symmetrical ataxia with one patient had severely debilitating ataxia and was not able to walk unassisted. Antibodies, Ataxia, Blood Proteins, Brain Diseases and Conditions, Breast Cancer, Cancer, Central Nervous System Diseases and Conditions, Cerebellar Degeneration, Central Nervous System, Cerebellar Diseases and Conditions, Dyskinesias, Health and Medicine, Immunoglobulins, Immunology, Nervous System Diseases and Conditions, Nervous System Paraneoplastic Syndromes, Neurodegenerative Diseases and Conditions, Neurologic Manifestations, Neurology, Oncology, Proteins, Women's Health, Paraneoplastic Cerebellar Degeneration Keywords: Antibodies; Ataxia; Blood Proteins; Brain Diseases and Conditions; Breast Cancer; Cancer; Central Nervous System; Central Nervous System Diseases and Conditions; Cerebellar Degeneration; Cerebellar Diseases and Conditions; Dyskinesias; Health and Medicine; Immunoglobulins; Immunology; Nervous System Diseases and Conditions; Nervous System Paraneoplastic Syndromes; Neurodegenerative Diseases and Conditions; Neurologic Manifestations; Neurology; Oncology; Paraneoplastic Cerebellar Degeneration; Proteins; Women's Health EN Antibodies Ataxia Blood Proteins Brain Diseases and Conditions Breast Cancer Cancer Central Nervous System Central Nervous System Diseases and Conditions Cerebellar Degeneration Cerebellar Diseases and Conditions Dyskinesias Health and Medicine Immunoglobulins Immunology Nervous System Diseases and Conditions Nervous System Paraneoplastic Syndromes Neurodegenerative Diseases and Conditions Neurologic Manifestations Neurology Oncology Paraneoplastic Cerebellar Degeneration Proteins Women's Health 293 293 1 09/04/23 20230905 NES 230905 2023 SEP 5 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Fresh data on paraneoplastic cerebellar degeneration are presented in a new report. [Extracted from the article]

Houston, State:Texas, United States, North and Central America, Brain Diseases and Conditions, Central Nervous System, Central Nervous System Diseases and Conditions, Cerebellar Degeneration, Epilepsy, Genetics, Health and Medicine, Neuroinflammation, Neurology, Risk and Prevention Keywords: Houston; State:Texas; United States; North and Central America; Brain Diseases and Conditions; Central Nervous System; Central Nervous System Diseases and Conditions; Cerebellar Degeneration; Epilepsy; Genetics; Health and Medicine; Neuroinflammation; Neurology; Risk and Prevention EN Houston State:Texas United States North and Central America Brain Diseases and Conditions Central Nervous System Central Nervous System Diseases and Conditions Cerebellar Degeneration Epilepsy Genetics Health and Medicine Neuroinflammation Neurology Risk and Prevention 1391 1391 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Central Nervous System Diseases and Conditions - Epilepsy have been presented. [Extracted from the article]

Keywords: Plzen; Czech Republic; Europe; Pain and Central Nervous System; Brain; Brain Research; Brain Stem; Central Nervous System; Cerebellar Cortex; Cerebellar Degeneration; Cerebellum; Health and Medicine; Metencephalon; Neurology; Neurons; Purkinje Cells; Rhombencephalon EN Plzen Czech Republic Europe Pain and Central Nervous System Brain Brain Research Brain Stem Central Nervous System Cerebellar Cortex Cerebellar Degeneration Cerebellum Health and Medicine Metencephalon Neurology Neurons Purkinje Cells Rhombencephalon 361 361 1 05/15/23 20230519 NES 230519 2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Pain and Central Nervous System have been published. Plzen, Czech Republic, Europe, Pain and Central Nervous System, Brain, Brain Research, Brain Stem, Central Nervous System, Cerebellar Cortex, Cerebellum, Health and Medicine, Metencephalon, Neurology, Neurons, Purkinje Cells, Rhombencephalon, Cerebellar Degeneration. [Extracted from the article]

Ataxia, Avitaminosis, COVID-19, Central Nervous System, Central Nervous System Diseases and Conditions, Cerebellar Degeneration, Coronavirus, Deficiency Diseases and Conditions, Health and Medicine, Malnutrition, Metabolic Brain Diseases and Conditions, Metabolic Diseases and Conditions, Nervous System Diseases and Conditions, Neurologic Manifestations, Neurology, Nutritional and Metabolic Diseases and Conditions, RNA Viruses, SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2, Thiamine Deficiency, Dyskinesias, Viral, Virology, Vitamin B Deficiency, Wernicke Encephalopathy Keywords for this news article include: Vincent van Gogh Institute for Psychiatry, Viral, Ataxia, COVID-19, Virology, SARS-CoV-2, Dyskinesias, RNA Viruses, Avitaminosis, Malnutrition, Health and Medicine, Thiamine Deficiency, Vitamin B Deficiency, Cerebellar Degeneration, Wernicke Encephalopathy, Neurologic Manifestations, Deficiency Diseases and Conditions, Metabolic Brain Diseases and Conditions. [Extracted from the article]