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A recent report from the University of Cordoba in Spain highlights the potential of bipyramidal gold nanoparticles in plasmonic photothermal therapy for ocular applications. The study emphasizes the biocompatibility and stability of these nanoparticles, particularly those functionalized with citrate and polystyrene sulphonate. The research suggests that these nanoparticles could be a promising tool in nanomedicine for addressing corneal diseases, as demonstrated in in vitro and ex vivo experiments. [Extracted from the article]

Researchers at the Egyptian Atomic Energy Authority (EAEA) have developed and evaluated 99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles for tumor targeting. The study synthesized a novel benzenesulfonamide derivative with anti-cancer activity and successfully created stable nanoparticles with optimal size and radiochemical purity. In-vivo investigations demonstrated the efficacy of these nanoparticles in targeting tumors with a high target-to-non-target ratio. This research showcases the potential of these nanoparticles for precise cancer treatment through targeted delivery. [Extracted from the article]

A study conducted at Gachon University in South Korea focused on evaluating the effects of protein coronas on the biosensing of antibody-immobilized nanoparticles using fluorescence nanoparticle tracking analysis. The research demonstrated a method to assess the influence of whole protein coronas on biosensing efficiency, specifically focusing on the interaction between anti-IgG and IgG-conjugated gold nanoparticles. The study concluded that the physical presence of protein coronas surrounding the nanoparticles may enhance the biosensing interaction rather than hinder it. For more information, the full article can be accessed for free at the publisher's website. [Extracted from the article]

Researchers from the Russian Academy of Sciences conducted a study on the use of a cold atmospheric plasma jet (CAPJ) in combination with gold nanoparticles to enhance the anticancer effect on various types of adenocarcinoma cells. The study found that the CAPJ, when optimized with specific pulse durations, significantly reduced the viability of cancerous cells. Additionally, the addition of gold nanoparticles further increased the cytotoxic effect of the plasma jet on the cancer cells. This research, supported by the Russian Science Foundation, highlights the potential of combining emerging technologies to improve cancer treatments. [Extracted from the article]

Researchers at Sun Yat-sen University in Shenzhen, China, have developed a cost-effective and convenient method for detecting 5-hydroxymethylcytosine (5hmC), a biomarker for early cancer detection. The method utilizes gold nanoparticles and a colorimetric strategy to accurately quantify 5hmC levels in mammalian tissues without the need for expensive instruments. This research offers promising clinical applications and has been peer-reviewed, providing accurate results comparable to standard methods. [Extracted from the article]

Researchers at Mahidol University in Bangkok, Thailand, have developed a novel approach to enhance the aqueous solubility and antibacterial activity of Triclosan (TCS) using a re-dispersible emulsion powder stabilized with gold nanoparticles (GNPs). The study demonstrated that the developed formulation showed high antibacterial activity against drug-resistant bacterial strains, including Escherichia coli and methicillin-resistant Staphylococcus aureus. The results suggest that this approach could potentially address the solubility concerns of TCS and improve its efficacy for future applications in antibacterial therapy. [Extracted from the article]

A patent has been issued for modular metal-organic polyhedra superassembly compositions by inventors from Albuquerque, New Mexico. The patent focuses on the development of nanosized metal-organic polyhedra for drug delivery systems, particularly in cancer therapy. The superassembly technique described in the patent combines the advantages of micelles and supramolecular coordination cages for targeted drug delivery, with a focus on enhancing drug efficacy and reducing side effects. The patent highlights the potential of these superassemblies for versatile bioapplications, including the delivery of various cargos and functional nanoparticles for targeted therapy. [Extracted from the article]

Researchers from Arizona State University have submitted a patent application for methods to detect and quantify Chimeric Antigen Receptor T cells in samples, aiming to improve monitoring of CAR-T cell therapy for cancer patients. The patent application outlines a diagnostic system that can quantify CAR-T cells from a drop of blood without the need for centrifugation. By utilizing a trained machine learning model and label-free imaging, this system can differentiate between CAR-T cells and non-CAR-T cells in a cell population, offering potential advancements in cancer treatment monitoring. [Extracted from the article]

Researchers at the Manav Rachna International Institute of Research & Studies in Faridabad, India, have conducted a study on the efficacy of green nanoparticles in enhancing plant defense mechanisms. The research highlights the benefits of using green nanoparticles derived from natural sources to boost plant health by activating defense responses and improving disease resistance. The study also discusses the challenges of optimizing green nanoparticles for cost-effectiveness and points towards promising future directions in sustainable agriculture. This peer-reviewed research sheds light on the role of systemic acquired resistance and induced systemic resistance in enhancing plant immune responses. [Extracted from the article]

A recent report from the Korea Research Institute of Standards and Science discusses the use of Au/Fe/Au trilayer nanodiscs as theranostic agents for magnet-guided photothermal, chemodynamic therapy, and ferroptosis with photoacoustic imaging. The study aims to address limitations in photothermal stability and provide magnetic targeting ability for more accurate spatiotemporal regulation. The research demonstrates the potential of these nanodiscs for photoacoustic imaging-guided therapy, chemodynamic therapy, and immune modulation in cancer treatment. [Extracted from the article]

A recent study conducted at Duke University introduced a new imaging technique called three-dimensional diffractive acoustic tomography (3D-DAT), which combines photoacoustic and ultrasound imaging to provide detailed anatomical and molecular information in deep tissues. This innovative method offers high imaging speed, near-isotropic resolutions, and enhanced quantitative accuracy, making it valuable for various applications in life sciences and biomedical research. The research findings were published in Nature Communications and can be accessed for free online. The study was funded by Duke University and Eli Lilly And Company, and involved a team of researchers led by Luca Menozzi from the Department of Biomedical Engineering at Duke University. [Extracted from the article]

A patent application titled "Cytokine Compositions And Methods Of Use Thereof" by inventor Giulio Franco Paciotti has been published online by Zahav Bioscience LLC. The application focuses on improving the targeted delivery of therapeutic agents, such as cytokines, to specific areas of the body to enhance treatment efficacy and reduce side effects. The invention involves constructs comprising colloidal gold particles, cytokines, and polyethylene glycol molecules, aiming to increase the potency and cytotoxicity of the therapeutic agents. The application outlines methods for inducing MHC-1 expression in cancer cells and increasing cytokine cytotoxicity, particularly in cancer cells like thyroid cancer and melanoma. [Extracted from the article]

Researchers at Ain Shams University have conducted a study on the use of a novel agent, cisplatin coupled to gold chitosan nanoparticles, in treating oral squamous cell carcinoma (OSCC) and oral epithelial cells. The study found that the nanocomposite showed promising results in inducing apoptosis, cell cycle arrest, and reactive oxygen species production in oral cancer cells, while having fewer negative effects on normal oral epithelial cells. This research provides valuable insights into potential alternative treatments for OSCC. [Extracted from the article]

Researchers from Pusan National University conducted a study on the biosynthesis of gold nanoparticles using vitalmelon extract without the need for stabilizers or surfactants. The nanoparticles were characterized and found to promote the browning of white adipocytes, potentially offering a novel therapeutic strategy to combat obesity by modulating adipocyte metabolism and increasing energy expenditure. The study suggests that these gold nanoparticles could be used to target phospholipase D2 and enhance the browning effects in adipocytes. [Extracted from the article]

Researchers have developed a new optical fiber sensor that can detect extremely low levels of arsenic in water, providing a simple and real-time solution for monitoring water quality. Arsenic contamination in water poses serious health risks, and this sensor offers a sensitive, selective, and cost-effective tool for routine monitoring. The sensor, which uses localized surface plasmon resonance, can detect arsenic levels as low as 0.09 parts per billion, well below the World Health Organization's limit of 10 ppb, making it a valuable resource for ensuring safer drinking water. [Extracted from the article]

A study conducted at Islamic Azad University in Tehran, Iran, introduced a colorimetric method using gold nanoparticles to detect trace amounts of dextromethorphan and pseudoephedrine in urine samples. The method relies on the color changes of gold nanoparticles in the presence of these substances, allowing for easy monitoring through visual observation or a UV-vis spectrophotometer. The research demonstrated precision and accuracy in drug analysis without the need for complex or expensive equipment, offering a simple and rapid approach to drug detection. [Extracted from the article]

Researchers at Inner Mongolia University in Hohhot, China, have developed a novel antibacterial material by combining N-halamine polymer with gold nanoparticles. This material aims to utilize both photothermal and chemical antibacterial mechanisms to effectively inhibit bacteria and reduce antibiotic resistance. The study provides a new strategy for combined antibacterial therapy, offering theoretical significance and reference value for the development of novel antibacterial drugs. The research has been peer-reviewed and published in the Chemical Journal of Chinese Universities. [Extracted from the article]

Researchers from Shahid Beheshti University of Medical Sciences in Tehran, Iran, have conducted a study on the protective effects of bioengineered silver and gold nanomaterials on liver and kidney health, based on animal-based evidence. The study highlights the potential therapeutic benefits of these nanoparticles in reducing hepatic enzymes and renal function markers in diseased animal models, while showing no significant impact on healthy animals at therapeutic doses. The research emphasizes the need for further investigation into the pharmacokinetics and pharmacodynamics of these nanoparticles for potential clinical applications. [Extracted from the article]

Researchers from Macquarie University in Sydney, Australia, have developed a label-free surface-enhanced Raman scattering system using gold nanoparticles to detect methylated DNA. This innovative method has a high specificity and can detect hypermethylated levels in colorectal cancer cell lines. The research holds promise for reading disease-associated methylation of genomic DNA, offering a simple and effective approach to studying epigenetic mechanisms. The study was funded by the Australian Research Council Discovery and published in the journal Molecules. [Extracted from the article]

A recent study conducted by researchers at China Pharmaceutical University has developed a label-free colorimetric aptasensor for detecting Flavokavain B (FKB), a hepatotoxic compound found in kava. The aptasensor, named FKB-S, showed a dissociation constant of 280 nM and achieved a detection limit of 150 nM within 10 minutes. This innovative approach offers a simple, cost-effective, and equipment-free method for on-site FKB detection, making it a valuable tool for quality control and safety monitoring of kava-based products in various settings. [Extracted from the article]

Researchers from North Eastern Hill University in Meghalaya, India, have published a study on the use of nanotechnology in the diagnosis and treatment of tuberculosis. Nanoparticles are being utilized to enhance imaging techniques like MRI for precise detection of diseases such as cancer and tuberculosis. This innovative approach allows for personalized medicine delivery directly to infected cells, bypassing traditional treatment barriers and improving therapeutic responses. The research highlights the potential of nanotechnology in revolutionizing healthcare by combining genetic mapping with nanotechnology for more accurate and personalized treatments. [Extracted from the article]

A recent study published in the International Journal of Oral Science introduces the Au-HN-1 nanosystem, a cutting-edge technology that targets and treats tongue squamous cell carcinoma (TSCC) with high precision. By utilizing gold nanoparticles coupled with the HN-1 peptide, this innovative system enhances photothermal therapy and dual-mode imaging capabilities, improving tumor ablation and surgical margin identification. The Au-HN-1 nanosystem shows promising potential for personalized cancer therapy, offering hope for more effective treatments with minimal side effects and improved patient outcomes. [Extracted from the article]

Researchers at the University of Jinan in China have made advancements in the detection of dopamine in glioblastoma cells using a cathode PEC sensing platform. By incorporating nitrogen vacancies in g-C3N5, they improved the photocurrent of the BiOBr photocathode. The study demonstrated the potential for PEC detection of dopamine with good stability and repeatability, offering new insights into oncology research. [Extracted from the article]

A study conducted by the Korea Photonics Technology Institute in Gwangju, South Korea, introduces a new method for rapid detection of Salmonella using gold nanoshells for photothermal conversion. This innovative photothermal quantitative PCR (PT-qPCR) technique reduces detection time to under 30 minutes while maintaining high amplification efficiency. The research suggests that this novel approach could lead to faster and more efficient food safety testing and public health management. The study was supported by the Ministry of Science & ICT and the Ministry of Trade, Industry & Energy in South Korea. [Extracted from the article]

Researchers from Shanghai Normal University have developed a SERS sensor using gold nanoparticles@polydopamine@poly(methyl methacrylate) MN (AuNPs@PDA@PMMA-MN) for food safety detection. The sensor showed high sensitivity and specificity in detecting putrescine and cadaverine in meat samples. This technology has potential applications in food quality testing, environmental monitoring, and disease diagnosis. The research was supported by various funding sources and has been peer-reviewed for accuracy and reliability. [Extracted from the article]

Researchers from Linyi University in China have developed a novel method for the rapid detection of microRNA-122 (miR-122) in serum and finger blood using a lateral flow nucleic acid biosensor (LFNAB). This approach offers advantages such as high specificity for miR-122, the ability to detect low concentrations of the target molecule, and reduced testing time compared to traditional methods. The study concluded that the LFNAB successfully detected miR-122 in both serum and fingertip blood samples, demonstrating its potential utility in clinical and research settings for assessing miR-122 levels in different biological samples. [Extracted from the article]

The patent application by Boston Scientific Scimed Inc. introduces a new hydrogel, SpaceOAR Vue, for prostate medical applications, enhancing radiopacity for CT-visibility. The hydrogel includes 8-Arm PEG branches functionalized with TIB groups to provide intrinsic radiopacity. The system involves a reactive polymer and gold nanoparticles forming covalent crosslinks, offering potential benefits such as enhanced crosslink density and in vivo persistence. [Extracted from the article]

Researchers at the Department of Applied Chemistry in Hsinchu, Taiwan, have conducted a study on gold nanoparticles and their role in enantioselectivity switch in chiral crystallization. The research explores the use of circularly polarized light to influence chirality and achieve high enantiomeric excess. The study highlights the effectiveness of altering the size of gold nanoparticles under optical trapping with circularly polarized light, resulting in a crystal enantiomeric excess of up to 37%. This research offers insights into light-driven chiral synthesis and the interplay of optical forces, spin-orbit interactions, and plasmonic heating in chiral crystallization. [Extracted from the article]

A recent study conducted at the University of Pennsylvania explored the impact of gold nanoparticle size on CT imaging of the gastrointestinal tract in patients with inflammatory bowel disease (IBD). The research found that gold nanoparticles coated with poly(ethylene glycol) (PEG) showed cytocompatibility with macrophage cells and remained stable under acidic conditions. In vivo imaging using a mouse model of acute colitis demonstrated strong contrast generation throughout the GI tract, with almost complete clearance of all formulations tested within 24 hours. The study suggests that nanoparticles could serve as effective contrast agents for CT imaging of the gastrointestinal tract in IBD, although further research is needed to explore agents that can specifically image disease processes in this setting. [Extracted from the article]

Researchers at Ibaraki University in Japan have developed gold nanoparticles coated with bismuth oxide for X-ray computed tomography imaging. The study aimed to enhance the biocompatibility and contrast-enhancing ability of gold nanoparticles for long-term diagnostic imaging. The findings suggest that the Au/Bi2O3/PVP nanoparticle colloidal solution showed superior X-ray imaging ability compared to commercial contrast agents, with potential applications for accurate and long-term observation of sentinel lymph nodes. This research was funded by the Japan Agency for Medical Research and Development (AMED) and has been peer-reviewed. [Extracted from the article]

A recent study conducted at Sichuan University in Chengdu, People's Republic of China, introduced a novel method for detecting Mycobacterium tuberculosis (MTB) using DNA-functionalized gold nanoparticles and an asymmetric RPA-triggered CRISPR system. This dual-mode sensing approach demonstrated high sensitivity and specificity, with a detection limit of 1 copy μL-1 and no cross-reactivity with other respiratory pathogens. The research findings suggest that this biosensing platform has potential for point-of-care applications and offers a reliable and accurate method for MTB detection. [Extracted from the article]

Metgen Incorporated has been issued a patent for a handheld Surface-Enhanced Raman Spectroscopy (SERS) device designed to detect biomarkers in samples collected from subjects. The device utilizes a nanoporous anodic aluminum oxide (NAAO) substrate with a multilayered nanoporous aluminum layer containing nanocavities. This innovation aims to provide a cost-effective and convenient solution for at-home biomarker testing, catering to patients with mobility issues or other constraints that limit clinic visits. The device's compact design and ability to detect multiple biomarkers make it a promising advancement in healthcare technology. [Extracted from the article]

Researchers have submitted a patent application for a "Lateral Flow Immunoassay Device For Albumin Detection" to the USPTO. The device aims to improve the sensitivity and efficiency of lateral flow immunoassay (LFIA) technology by utilizing a glass-based platform instead of traditional paper-based methods. This innovation could lead to enhanced detection capabilities for low-concentration samples, reduced costs, and improved detection efficiency, with potential applications in various fields including clinical medicine, biomedicine, and food sanitation. [Extracted from the article]

Researchers from Ladoke Akintola University of Technology conducted a study comparing the effectiveness of iodine-based and biosynthesized gold nanoparticles as X-ray contrast agents and their impact on renal functions in rats. The study found that rats injected with biosynthesized gold nanoparticles showed better radiographic contrast and protected against nephropathy compared to those injected with iodine-based contrast agents. The research suggests that biosynthesized gold nanoparticles could be a suitable alternative to iodine-based contrast agents due to their properties and biocompatibility. For more information, readers can refer to the Iranian Journal of Medical Physics. [Extracted from the article]

Researchers at Nanchang University in China have developed a method to enhance the sensitivity of lateral flow immunoassays using branched gold nanoparticles (BGNPs) as signal labels. By selectively passivating the surface of the gold nanoparticles, they were able to improve the detection sensitivity for various substances in fruits. The BGNPs-LFIA method showed lower limits of detection compared to traditional AuNPs-LFIA, demonstrating promise for future applications in immunoassays. This study provides valuable insights into selecting appropriate signal labels for lateral flow immunoassays. [Extracted from the article]