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Researchers from Leiden University Medical Center have conducted a study on osteoarthritis, a prevalent musculoskeletal disorder influenced by aging and obesity. While advancements have been made in understanding genetic factors and pain mechanisms, new treatment options are still needed. The study emphasizes the importance of managing obesity and maintaining activity, considering individual and cultural preferences for optimal outcomes. Targeting inflammation shows promise in treating hand osteoarthritis, with ongoing research for effective disease-modifying drugs. [Extracted from the article]

A recent study conducted at the University of Utrecht in the Netherlands has focused on reactions to no-fault compensation schemes for occupational diseases. The research examines the role of perceived procedural justice, outcome concerns, and trust in authorities among victims involved in these schemes. The study aims to offer insights into the experiences of applicants and the effectiveness of such compensation systems in promoting fairness and justice. [Extracted from the article]

A report from Radboud University Nijmegen discusses the use of conceptual review as a method for addressing issues of task comparability and validity in cognitive neuroscience studies. The research emphasizes the importance of analyzing experimental contrasts in tasks to determine comparability between studies, as labels applied to studies may not accurately reflect the tasks being conducted. By introducing conceptual review as a method for task analysis, researchers aim to shed light on the precise concepts studied and improve the comparability and validity of cognitive neuroscience studies. This research has been peer-reviewed and is available in the European Journal of Neuroscience. [Extracted from the article]

A study conducted by the Department of Pathology in Amsterdam, Netherlands, focused on using DNA methylation analysis on anal swabs to screen for anal cancer in individuals living with HIV/AIDS. The research found that methylation analysis on anal swabs could potentially identify patients at higher risk for anal cancer, reducing unnecessary screenings and treatments. This method could make anal cancer screening more accessible and efficient for individuals with HIV/AIDS. The study was supported by the Dutch Cancer Society and Amsterdam UMC, among others, and has been peer-reviewed. [Extracted from the article]

A recent study from Wageningen University in the Netherlands explored the transfer of lipophilic cargoes from lipid droplets to lipid bilayers using liposomes. The research found that curcumin, an amphiphilic molecule, was successfully transferred from lipid droplets to liposomes, while Nile red remained in the droplets. This study sheds light on the transportation mechanism of molecules from lipid droplets to bilayers, which could have implications for utilizing lipid droplets as natural lipid carriers. [Extracted from the article]

A recent study conducted at the Amsterdam Rheumatology and Immunology Center focused on comparing the effects of tumor necrosis factor blockers (anti-TNF) and Janus kinase inhibitors (JAKi) on the coagulation system of rheumatoid arthritis (RA) patients. The study found that both treatments led to a decline in prothrombotic tendency in active RA patients, with no significant increase in venous thromboembolism (VTE) risk within the first 6 months of treatment. This research provides valuable insights into the impact of different therapies on coagulation activation in RA patients. [Extracted from the article]

A recent study from the University of Utrecht in the Netherlands explores self-controlled designs in pharmacoepidemiology to address challenges related to uncontrolled confounding in research on Obesity, Fitness, and Wellness. The study emphasizes the benefits of self-controlled designs in controlling for time-stable confounders and eliminating the need for external control groups, while acknowledging the strong assumptions involved. Researchers hope that this review will assist others in applying self-controlled designs in their own work. The study has been peer-reviewed and provides a practical guide for implementing and visualizing self-controlled study designs. [Extracted from the article]

The patent issued for a lithographic apparatus and method by ASML Netherlands B.V. involves the use of immersion lithography to transfer patterns onto substrates, particularly in the manufacture of integrated circuits. The invention focuses on reducing thermal expansion and contraction effects caused by the presence of liquid on the substrate, utilizing heaters and temperature sensors on the substrate holder to mitigate imaging errors. The patent details various configurations of heaters and sensors on the substrate holder to support substrates in lithographic apparatuses, aiming to improve the accuracy and efficiency of the process. [Extracted from the article]

A recent report from Radboud University Nijmegen in the Netherlands discusses the incorporation of ionizable lipids into the outer shell of lipid-coated calcium phosphate nanoparticles to enhance cellular mRNA delivery. The study highlights the importance of packaging mRNA into delivery vehicles that shield it from degradation and mediate uptake for potential therapeutic applications. This research offers new insights into the use of ionizable cationic lipids in nanocarriers to improve the endosomal release of nucleic acids, presenting a novel approach in biopharmaceutical development. [Extracted from the article]

A study conducted at the University Medical Center Utrecht in the Netherlands explored the impact of a 12-week exercise program post-esophagectomy on the 2- and 5-year survival rates of esophageal cancer patients. The results showed that there was no significant difference in survival rates between the exercise group and the control group after 2 and 5 years. The researchers suggested that the lack of beneficial effects may be due to the short duration of the exercise program post-treatment. [Extracted from the article]

Recent research from Radboud University Nijmegen Medical Center in the Netherlands explores the impact of pelvic floor rehabilitation (PFR) on patients who have undergone rectal cancer surgery. The study found that while PFR did not significantly improve fecal incontinence scores after one year, it was associated with enhanced quality of life compared to standard care. This peer-reviewed study sheds light on the challenges faced by patients post-surgery and the potential benefits of PFR in improving their overall well-being. [Extracted from the article]

Researchers from the Helen Dowling Institute in the Netherlands conducted studies on chronic cancer-related fatigue (CCRF) and found that targeting both patients and their partners in therapy may be more beneficial than focusing solely on the patient. Through qualitative and quantitative methods, they discovered that a dyadic approach to CCRF therapy could empower partners to support patients, improve communication, and address individual needs. The research suggests that a flexible couples therapy approach could be acceptable and effective in managing CCRF. [Extracted from the article]

A recent study from the University of Amsterdam explores the use of Mendelian randomization to investigate causal effects on atrial fibrillation (AF) in the field of arrhythmia. The research highlights risk factors for AF such as high systolic blood pressure, low resting heart rate, elevated cardiac troponin I levels, coronary artery disease, and heart failure. By leveraging genetic data, Mendelian randomization offers insights into causal relationships in cardiovascular traits. The study emphasizes the importance of sensitivity analyses and integrating multiple methodologies to enhance the robustness of causal inferences in research on AF and cardiovascular traits. [Extracted from the article]

A report from Radboud University Medical Center in the Netherlands discusses the prevalence of vitamin D deficiency in patients with chronic kidney disease (CKD) and the importance of monitoring and correcting deficiency levels. The research emphasizes the need for targeted vitamin D supplementation in children and adults with CKD and after kidney transplantation, with specific recommendations for optimal 25-hydroxyvitamin D levels. Future clinical trials are suggested to further investigate the benefits of vitamin D supplementation in CKD patients. The study was peer-reviewed and published in Nephrology Dialysis Transplantation. [Extracted from the article]

A study conducted in Rotterdam, Netherlands, aimed to establish a core set of quality indicators for Hirschsprung's disease care in Europe. Through a consensus-driven process involving healthcare professionals and patient representatives, 12 baseline characteristics and 14 quality indicators were identified. These indicators are intended to improve care quality and outcomes for children with Hirschsprung's disease within the European Paediatric Surgical Audit framework. [Extracted from the article]

A recent study conducted at the Princess Maxima Center for Pediatric Oncology in Utrecht, Netherlands, explored how pediatric oncologists communicate leukemia diagnoses to families. The study found that oncologists aim to balance providing necessary information with addressing the emotional needs of families during these conversations. Future research is recommended to assess how families perceive these communication strategies. The full study can be accessed in the journal Pediatric Blood & Cancer. [Extracted from the article]

A recent study conducted at Erasmus University Medical Center in Rotterdam, Netherlands, focused on parents' perspectives on continuity of care in maternity care and child health services. The research highlighted the importance of easily accessible, family-centered care that promotes interprofessional collaboration and empowers parents. The study emphasized the need for well-prepared parents entering the postnatal period, limited care transfers, and consistent, tailored information to maintain meaningful relationships with care providers. This qualitative systematic review provides valuable insights into enhancing integrated care services for families. [Extracted from the article]

A study conducted at the Princess Maxima Center for Pediatric Oncology in Utrecht, Netherlands, focused on the prognostic value of baseline EARL standardized FDG PET indices in pediatric and adolescent high-grade osteosarcoma. The research found that baseline SUV, TLG, and MTV measured on EARL-accredited reconstructions were not prognostic factors for survival in this patient population. The study questioned the value of a single proposed cutoff for these indices due to a wide range of values with similar prognostic value, highlighting the need for further validation and addressing technical and statistical issues. [Extracted from the article]

A study conducted at Erasmus University Medical Center in the Netherlands focused on pharmacogenetic testing to predict methylphenidate treatment outcomes in children with ADHD in Turkey. The research examined genetic polymorphisms in CES1, LPHN3, and COMT and their association with adverse effects in children receiving methylphenidate. The study found significant relationships between specific genotypes and adverse effects in children treated with methylphenidate, suggesting a potential link between genetic variations and treatment outcomes in ADHD. The research was peer-reviewed and published in the American Journal of Medical Genetics Part B. [Extracted from the article]

Researchers from Zuyderland Medical Center in Heerlen, Netherlands, have developed a model called ZHISLE to predict mortality risk in elderly patients undergoing surgery for proximal femoral fractures. The model, validated internally and compared to existing scores, showed good predictive power with a 16.8% mortality rate within 183 days post-surgery. The research suggests that the ZHISLE model could help identify patients who may benefit from alternative treatment options or a conservative approach. This study has been peer-reviewed and offers valuable insights for healthcare professionals managing elderly patients with femoral fractures. [Extracted from the article]

A study conducted at Sint Maartenskliniek in the Netherlands explored the association between zonal fixation of hybrid tibial components in revision total knee arthroplasty (rTKA) and subsequent aseptic loosening. The research found that patients needing further revision surgery for aseptic loosening had lower epiphyseal bone resection levels and fewer sufficiently cemented metaphyseal zones following rTKA. The study highlights the importance of appropriate metaphyseal fixation in revision knee arthroplasty surgery, providing valuable insights for orthopedic surgeons to identify at-risk patients and optimize surgical techniques. [Extracted from the article]

Researchers from the Department of Intensive Care in Delft, Netherlands, conducted a study on mechanical power in critically ill patients requiring invasive ventilation. The study found that high mechanical power is associated with mortality, with respiratory rate and peak pressure being the most significant factors contributing to increased mechanical power. The research suggests that adjusting the respiratory rate may be the most effective way to lower mechanical power in patients without acute respiratory distress syndrome. The study was peer-reviewed and published in Anaesthesia, and more information can be obtained from the authors or the journal's website. [Extracted from the article]

A recent study conducted at St. Antonius Hospital in Nieuwegein, Netherlands, focused on the benefits of pretreatment with pulmonary hypertension (PH)-targeted medical therapy before balloon pulmonary angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). The study included 92 CTEPH patients who underwent BPA treatment, with most patients receiving dual oral PH-targeted medical therapy prior to the procedure. Results showed significant improvements in clinical and pulmonary hemodynamic parameters in patients who received PH-targeted medical therapy before BPA, with a low overall complication rate. The research concluded that pretreatment with PH-targeted medical therapy prior to BPA leads to positive outcomes in patients. [Extracted from the article]

A recent study conducted in Leiden, Netherlands, by GGZ Rivierduinen focused on the impact of parental autonomy support (AS) and psychological control (PC) on adolescent depression. The research aimed to develop a reliable coding system for observing AS and PC in parent-adolescent interactions and their relation to adolescent depression. Findings indicated that adolescents with depression perceived parenting more negatively, and observed PC was associated with a lower affective state in these adolescents. The study suggests that parents could benefit from psycho-education on the impact of their behavior in a clinical setting. [Extracted from the article]

A recent study conducted at the University of Humanistic Studies in Utrecht, Netherlands, explored the impact of psychotherapy on the sense of meaning in life among patients with personality disorders. The research found that levels of meaning decreased and increased during treatment, with changes in identity pathology significantly associated with these shifts. The study suggests that psychotherapy may help individuals with personality disorders develop a sense of meaning in life, emphasizing the importance of identity and self-direction in this process. [Extracted from the article]

A study conducted at Maastricht University in the Netherlands examined the effects of an intervention targeting social media app use on well-being outcomes. The research found that while there were no significant time x group effects, participants in the intervention condition reported higher well-being and lower negative affect and stress levels at follow-up. The study suggests that interventions tailored to individuals with higher levels of problematic smartphone use may be more effective in reducing stress. Further research with a larger sample size is recommended to validate these findings. [Extracted from the article]

A recent study conducted at the University Medical Center Utrecht in the Netherlands aimed to identify subgroups within the chronic pain population using psychological variables. The research identified three distinct clusters of chronic pain patients based on psychological traits, with one group showing poorer treatment outcomes due to higher psychological burden. The findings suggest that tailoring therapies to specific patient subgroups could lead to improved treatment outcomes. This research has been peer-reviewed and offers valuable insights for clinicians seeking to enhance chronic pain management strategies. [Extracted from the article]

A recent study conducted at the University of Groningen in the Netherlands examined the relationship between weight loss trajectories and changes in psychological health over a two-year period following bariatric metabolic surgery. The research involved 529 patients with severe obesity who reported their health-related quality of life and depression levels before and after surgery. The study found that while most patients experienced improvements in BMI and quality of life post-surgery, some individuals showed worsening depression outcomes. The findings highlight the importance of considering psychological health as a crucial aspect of surgical outcomes, urging clinicians to prioritize mental well-being alongside weight loss in post-surgery care. [Extracted from the article]

A study conducted at Radboud University Medical Center in the Netherlands focused on co-creating a person-centered creative engagement intervention for individuals with Parkinson's disease. The research emphasized the beneficial impact of arts-based interventions on health and well-being, especially in cases where conventional healthcare falls short. The study involved collaboration between individuals with Parkinson's, creative therapists, and researchers to develop a 10-week creative arts therapy intervention in a 'creative playground' setting, highlighting the importance of autonomy in care and the individuality of disease experience. Future research will evaluate the effectiveness and scalability of this intervention in diverse settings. [Extracted from the article]

A recent study conducted at the University Medical Center Groningen in the Netherlands focused on individuals with chronic kidney failure on dialysis who perceive little control in life. The research aimed to enhance their perceptions of control through an intervention, but found that most patients did not accept the intervention, especially older individuals. The study highlighted the need for further qualitative research to understand the personal experiences and reasons behind the reluctance to accept psychological care to increase perceptions of control in life. [Extracted from the article]

A recent study conducted at Tilburg University in the Netherlands explored the psychological factors influencing individuals' willingness to share health-related data from technological devices. The research found that higher levels of optimism and psychological flexibility, along with lower levels of social inhibition, were associated with a greater willingness to share health technology data. The study suggests that understanding these psychological factors can help facilitate the optimal use of devices in healthcare. [Extracted from the article]

A recent study conducted at the University of Amsterdam focused on evaluating the long-term gastrointestinal effects of pyloromyotomy in children who underwent the procedure for infantile hypertrophic pyloric stenosis. The research found that children who had pyloromyotomy did not exhibit significant differences in gastrointestinal symptoms compared to healthy controls, suggesting that long-term sequelae of the surgery are rare. The study concluded that there may not be a need for long-term follow-up, providing valuable information for parental counseling. [Extracted from the article]

Researchers at Leiden University Medical Center have published a study on Cerebral Amyloid Angiopathy, a brain disorder common among the elderly and individuals with Alzheimer's disease. The study discusses the pathophysiology and phenotypes of CAA, highlighting the long preclinical phase and variable disease course. The research suggests a complex interplay between brain clearance, inflammation, and vascular remodeling in CAA, leading to diverse clinical outcomes. The findings indicate emerging evidence of sporadic, hereditary, inflammatory, and iatrogenic CAA, shedding light on the disease process. [Extracted from the article]

Researchers from the University of Groningen conducted a study on the influence of cognitive reserve (CR) on brain processes during a selective visual attentional processing task in older adults after mild traumatic brain injury (mTBI). The study involved 17 older adults with mTBI and 19 age- and CR-matched participants without mTBI. The findings suggest that older adults with mTBI and higher CR may employ more brain resources, resulting in slower processing but similar performance on attentional tasks. Further research with more participants is needed to better understand the implications of these findings. [Extracted from the article]

A recent study compared the epidemiology and acute care provision for traumatic brain injury (TBI) patients in Europe and India. The research found significant differences in demographics, injury causes, treatment characteristics, and outcomes between the two regions. Patients in India were younger, more likely to have severe TBI, and had different patterns of care and discharge destinations compared to European patients. The study highlights the disparities in neurotrauma care between India and Europe, suggesting unique challenges for each healthcare system in the future. [Extracted from the article]

A recent study from Vrije Universiteit Amsterdam explored the relationship between the strength of electric fields induced by Electroconvulsive Therapy (ECT) and cognitive and antidepressant outcomes in depressed patients. The research found that higher E-field strength was associated with a decline in verbal fluency in specific brain regions, highlighting the importance of individualized dosing strategies to optimize cognitive outcomes while maintaining the therapy's antidepressant efficacy. The study was funded by various organizations and has been peer-reviewed, providing valuable insights into the effects of ECT on cognitive function and depression outcomes. [Extracted from the article]

Researchers at the University of Amsterdam have developed a new electrochemical method for converting benzyl alcohol to benzyl-tert-butylamine, a compound used in pharmaceuticals and fine chemicals. The study, funded by various organizations, found that the number of nickel monolayer equivalents on the catalyst significantly influenced the selectivity of the reaction. This work demonstrates a more sustainable and efficient route for synthesizing amines, paving the way for future advancements in electrochemical synthesis. [Extracted from the article]

A study conducted at the University of Utrecht in the Netherlands explored the production of xylitol from agricultural by-products using the fungal cell factory Aspergillus niger. The research focused on the roles of transcription factors XlnR and CreA in xylitol production, revealing that a mutation in XlnR increased the initial rate of xylitol production but decreased overall accumulation, while deletion of creA improved both onset and rate of xylitol production. The study highlights the complexity of metabolic engineering in generating fungal cell factories for valuable biochemicals like xylitol, emphasizing the importance of considering both metabolic and gene regulation aspects. [Extracted from the article]

Researchers at the University of Twente in Enschede, Netherlands, have developed porous hybrid networks using recombinant human-like collagen and poly(trimethylene carbonate-co-c-caprolactone) to address mechanical and bioactivity limitations. These networks showed improved tensile properties and suture retention strength compared to collagen alone, particularly the 17:83 wt% collagen:polymer network. The study suggests that these hybrid hydrogel networks hold promise for further investigation in tissue engineering applications. The research has been peer-reviewed and published in Biomaterials Advances. [Extracted from the article]

A recent international study conducted by Leiden University Medical Center examined variations in the management and outcomes of haemolytic disease of the fetus and newborn in at-risk pregnancies. The study analyzed data from 2420 pregnancies with haemolytic disease, revealing differences in antenatal treatment, complications, and gestational age at birth across 31 centers in 22 countries. The research highlighted the importance of gathering valuable data on rare diseases to optimize care, showcasing the capacity of the field to improve patient outcomes. [Extracted from the article]

The University of Amsterdam conducted a study using machine learning to predict the risk of Periodontal Disease (PD) based on nonimage electronic dental records (EDRs) collected from dental patients in the US. The study found that the Random Forest model performed well in predicting PD, with high sensitivity and excellent accuracy. The research suggests that machine learning models could assist in early detection and prevention of PD cases, leading to improved patient outcomes and sustainable electronic dental records. Further research is needed to validate and improve the model for personalized risk predictions and targeted prevention interventions. [Extracted from the article]

A recent study from Medical Spectrum Twente in Enschede, Netherlands, compared the implant survival rates of hemiarthroplasty (HA) and total shoulder arthroplasty (TSA) in patients with atraumatic avascular necrosis of the humeral head. The research found no significant difference in short- to mid-term implant survival between the two types of arthroplasty, with revision rates of 4% for HA and 7% for TSA within four years. This study provides valuable insights into the treatment of this condition and was published in The Bone & Joint Journal. [Extracted from the article]

The article discusses the long-term outcomes of the Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) technique in patients with aorto-iliac occlusive disease. The study found that the CERAB technique led to good long-term outcomes, especially in primary cases, with high patency rates and clinical improvement. Patients who had not been previously treated in the target area had significantly better patency rates. The research suggests that CERAB is a valid treatment option for patients with extensive aorto-iliac occlusive disease, but patients previously treated in the target area may require other treatment options or more intensive follow-up surveillance. [Extracted from the article]

A recent study from the Department of Internal Medicine in Amsterdam, Netherlands, examined the relationship between Cerebral Small-Vessel Disease (CSVD) and all-cause mortality in geriatric outpatients. The study found that the presence of CSVD, as determined by brain imaging, was associated with an increased risk of mortality, even after adjusting for key confounders such as cardiovascular disease, physical function, and cognitive function. The researchers concluded that integrating the assessment of CSVD into daily care is crucial due to its independent link to higher mortality rates in this population. [Extracted from the article]

A study conducted at the University Medical Center Groningen in the Netherlands investigated the relationship between midazolam serum concentrations and pediatric delirium in critically ill children. The research found that a sudden and significant reduction in midazolam concentration may be linked to the development of pediatric delirium in these patients. Further research with larger patient populations is needed to validate these findings. The study was published in Pediatric Reports in 2025 and can be accessed online for more information. [Extracted from the article]