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Researchers at the Luxembourg Institute of Health have identified a new vitamin concept, vitamin A5, which plays a crucial role in mental health and brain function. They recommend a daily intake of 1.1 mg of vitamin A5, but found that many individuals in Western countries fall short of this recommendation. The researchers suggest increasing fruit and vegetable consumption or considering fortification and supplementation to address this deficiency. [Extracted from the article]

Research from Chongqing Hospital of Traditional Chinese Medicine discusses the successful treatment of Follicular occlusion triad (FOT) using adalimumab combined with isotretinoin. The study also reviews current research progress on biologic therapies for FOT, highlighting the effectiveness of adalimumab and secukinumab. Biologic therapies have significantly improved FOT management for patients who do not respond to conventional treatments, with ongoing advancements expected in this field. [Extracted from the article]

A study conducted at the University of Jordan focused on acne vulgaris and the use of isotretinoin as a treatment. The research analyzed laboratory abnormalities and changes in inflammatory parameters in 1182 patients over a five-year period. The study found that a baseline cholesterol level of 163.9 mg/dl and a baseline triglycerides level of 85.5 mg/dL were effective in detecting grade 1 abnormalities in patients receiving isotretinoin. This novel predictive method could serve as an effective risk stratification tool for acne patients undergoing isotretinoin treatment. [Extracted from the article]

The article discusses a systematic review on the outcomes and adverse effects of isotretinoin in acne treatment conducted by researchers at Cardinal Stefan Wyszynski University in Warsaw. Isotretinoin, a drug used for moderate to severe acne that is unresponsive to other treatments, is highlighted for its effectiveness in preventing physical scarring and psychological impacts associated with severe acne. The review emphasizes the importance of careful patient management due to isotretinoin's teratogenic nature, particularly for women of reproductive age who must use contraception during treatment. The research underscores the drug's inhibitory effect on sebaceous gland activity and proliferation, while cautioning about potential side effects across various body systems. [Extracted from the article]

A Phase 2 clinical trial, NCT06698822, is being conducted to evaluate the safety and efficacy of tofacitinib 2% cream in treating early-stage Cutaneous T-cell Lymphoma (CTCL) stages IA, IB, and IIA. The trial aims to assess the safety of the cream and the overall response rate of target lesions at Week 12. Participants will apply the cream twice daily on up to 5 treatment-eligible skin lesions. The study is not yet recruiting and is expected to be completed by October 19, 2026. [Extracted from the article]

A recent study conducted at Ain Shams University evaluated the efficacy and safety of chlorophyllin-IPL mediated photodynamic therapy in treating periungual and subungual warts caused by human papillomavirus. The study involved 60 patients divided into two groups receiving different treatments, with results showing a statistically significant decrease in wart size in both groups, with better outcomes in the methylene blue group. The research concluded that both methylene blue and chlorophyllin are effective photosensitizers in photodynamic therapy for warts, with methylene blue being more effective. [Extracted from the article]

A patent application by inventors Chen and Palczewski focuses on treating inherited ocular disorders caused by misfolded proteins, specifically targeting retinitis pigmentosa (RP) associated with mutations in the RHO gene. The application discusses the importance of maintaining rhodopsin homeostasis in rod photoreceptor cells and proposes compounds that can reduce misfolded ocular proteins to preserve visual function and prevent photoreceptor death. The methods outlined in the patent application aim to accelerate the degradation of misfolded ocular proteins, improve ocular protein homeostasis, and preserve retinal structure in subjects with inherited ocular disorders. [Extracted from the article]

A study conducted by the University of Costa Rica focused on evaluating the effects of the retinoid fenretinide on primary and metastatic intestinal gastric cancer cell lines. The research found that fenretinide reduced the viability of both cell lines and inhibited cell migration. The study suggests that combining fenretinide with conventional therapies may improve survival rates in advanced or metastatic gastric cancer. The research was supported by financial assistance from Vicerrectora de Investigacin, Universidad de Costa Rica and has been peer-reviewed. [Extracted from the article]

A clinical trial, NCT06698263, is being conducted to assess the impact of weekly isotretinoin administration on sperm production in men with oligozoospermia. Participants will be randomly assigned to receive either isotretinoin or a placebo, with the primary outcome being changes in sperm production over a 20-week treatment period. The study aims to determine if isotretinoin can stimulate spermatogenesis and improve sperm count in infertile men. [Extracted from the article]

A study conducted by Xiamen University in Fujian, China, analyzed adverse drug reactions related to dry eye using data from the FDA Adverse Event Reporting System. The research identified 33 drugs with significant risk of causing dry eye, with isotretinoin, tisotumab vedotin, and brimonidine being the top three. The study highlighted the importance of informed clinical decision-making to prevent drug-related dry eye, especially among females and elderly individuals. This research aims to optimize treatment and provide cautionary information regarding the risk of dry eyes associated with various medications. [Extracted from the article]

Researchers at Mustansiriyah University in Baghdad, Iraq, have developed a new approach to topical anticellulite therapy using a nanoemulgel (NEG) containing caffeine, aminophylline, and tretinoin. The study also investigated the impact of microneedles (MNs) as a skin pre-treatment on the permeation of the NEG. Results showed that the combined approach of NEG formulation and MNs application has the potential to reduce cellulite formation and improve skin appearance. This research offers a promising strategy for addressing cellulite concerns. [Extracted from the article]

A researcher from the University of Bologna has published new studies on colon cancer, focusing on the antiproliferative and morphological effects of fenretinide lipid nanosystems in colon adenocarcinoma cells. The study found that fenretinide encapsulated in lipid nanosystems was more effective in inhibiting cell proliferation and decreasing cell growth compared to free fenretinide. The research suggests that these nanosystems could be a valuable alternative to natural retinoids in the chemoprevention and treatment of colorectal cancer. [Extracted from the article]

A patent has been issued for compositions aimed at treating psoriasis, a chronic inflammatory skin disease affecting millions worldwide. The patent focuses on pharmaceutical compositions containing binding molecules that target human IL-17A, with a particular emphasis on single domain antibodies for topical administration. These compositions offer a potential treatment option for psoriasis and other autoimmune diseases associated with IL-17A signaling, providing a new avenue for therapeutic intervention in skin disorders. [Extracted from the article]

A patent has been issued for stabilized microcapsules containing tretinoin and benzoyl peroxide, developed by Sol-Gel Technologies Ltd. The microencapsulation technology aims to enhance the stability and effectiveness of these compounds in treating skin conditions like acne and rosacea. The patent details the composition, preparation method, and potential uses of these microcapsules in topical treatments for various skin diseases, providing a promising avenue for improved therapeutic outcomes. [Extracted from the article]

A recent study conducted at the University of Tennessee Health Science Center focused on isotretinoin, a form of Vitamin A used to treat severe acne vulgaris. The research highlighted the unique physical and mental side effects experienced by patients on isotretinoin, emphasizing the importance of patient-provider shared decision-making and open dialogue about side effects during monthly visits. The study recommended that dermatologists should present all treatment options to patients and consider creating a systematic documentation of symptoms to guide treatment plans. [Extracted from the article]

A patent has been issued to Aldeyra Therapeutics Inc. for the treatment of diseases related to toxic aldehydes, such as retinaldehyde, which can lead to conditions like Age Related Macular Degeneration. The patent discusses the use of small molecule therapeutics to reduce toxic aldehyde levels and mitigate the risk of various diseases, including ocular conditions like rosacea and skin disorders like psoriasis. The method involves administering compounds to address aldehyde toxicity implicated in the pathogenesis of these diseases. [Extracted from the article]

Researchers at Bagcilar Training and Research Hospital conducted a study on nail changes in patients receiving systemic isotretinoin therapy for acne vulgaris. The study included 200 patients, with 100 receiving isotretinoin treatment and 100 receiving topical acne treatment. The research found that isotretinoin increased the risk of nail changes, with onychoschizia being the most common change observed. The study concluded that the risk of developing nail changes was associated with the total cumulative dose of isotretinoin and that the changes were reversible. [Extracted from the article]

A recent study conducted at Universitat Autonoma de Barcelona focused on targeting retinaldehyde dehydrogenases to enhance temozolomide therapy in glioblastoma, an aggressive malignant brain tumor. The research highlighted the role of aldehyde dehydrogenases in glioma stem cells and their potential as pharmacological targets in cancer treatment. The study tested novel ALDH inhibitors on human and murine glioblastoma cell lines, showing promising results in decreasing ALDH activity and suggesting a potential new approach for glioblastoma treatment. [Extracted from the article]

A patent application titled "Methods For The Treatment Of GPP" has been published online, focusing on the severe skin disease Generalized Pustular Psoriasis (GPP). The inventors propose using biotherapeutics, particularly antibodies that bind to IL-36R, to provide therapeutic or prophylactic therapy for GPP, including acute flares. The method involves administering two 900 mg intravenous doses of an anti-IL-36R antibody to treat GPP flares, with the second dose given less than 2 weeks after the first dose. This novel targeted therapy aims to address the limited treatment options currently available for GPP, offering potential benefits in reducing symptoms and improving quality of life for patients. [Extracted from the article]

Researchers from Southern Medical University in Guangzhou, China, have developed a transdermal delivery system using microneedle patches containing poly (lactic-co-glycolic)-encapsulated acitretin nanoparticles for the treatment of psoriasis. This innovative system allows for effective topical drug administration and prolonged therapeutic effects, with less systemic toxicity compared to oral administration. The research demonstrates promising results for the treatment of psoriasis and offers a new approach to drug delivery and disease treatment. The study was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

Researchers at Silpakorn University in Thailand have developed a novel delivery system for retinaldehyde (RAL) using flexible liposomes infused with alpha-tocopherol succinate (a-TS) to enhance skin permeability. The liposomes were embedded in pressure-sensitive adhesive (PSA) hydrogels, which showed improved stability, skin permeation, and adhesion capabilities. The study concluded that the developed hydrogels could serve as an effective platform for delivering RAL in treating skin conditions. The research was funded by Silpakorn University Under The Postdoctoral Fellowship Program and can be accessed in the journal Polymers. [Extracted from the article]

Researchers at Universidad Autonoma de Bucaramanga conducted a study on the use of isotretinoin and its potential link to inflammatory bowel disease (IBD). While isotretinoin is effective in treating severe acne, concerns have been raised about its association with IBD. The study found a lack of substantial scientific evidence supporting a causal relationship between isotretinoin use and the development of IBD. For more information, readers can refer to the article "The use of isotretinoin increases the risk of inflammatory bowel disease. A narrative review" published in the Iberoamerican Journal of Medicine. [Extracted from the article]

The article discusses a clinical trial, NCT06644157, focusing on the treatment and prevention of melasma relapses using a 1064nm 650 microsecond laser. Melasma is a hyperpigmentary disorder affecting child-bearing women, with the trial aiming to enhance the efficacy of depigmenting agents and reduce relapses by using laser treatment. The study involves applying a depigmenting cream and sunscreen, along with laser sessions, to evaluate the treatment's effectiveness. The trial is not yet recruiting participants and is set to be completed by September 1, 2026. [Extracted from the article]

The article discusses the importance of psychological follow-up in rhinoplasty, specifically focusing on the use of isotretinoin as a skin preparation agent. Research suggests that while isotretinoin has beneficial effects on skin preparation, its continuous use before rhinoplasty may interfere with healing and increase the risk of hematological changes. The decision to use isotretinoin should be individualized, taking into account the surgeon's experience, patient characteristics, and balancing aesthetic benefits with potential risks. A collaborative approach between plastic surgeons, dermatologists, and patients is essential for safe and effective use of isotretinoin in rhinoplasty. [Extracted from the article]

Researchers from George Washington University conducted a study on the readability of the iPLEDGE Comprehension Assessment (iPCA) used in the treatment of severe nodular acne with isotretinoin. The study found that the language complexity of the iPCA may hinder patient comprehension, leading to delays and potential discontinuation of treatment, especially among female patients. The researchers suggest that simplifying the iPCA could improve patient safety, comprehension, and access to isotretinoin, despite a decrease in isotretinoin-exposed pregnancies since the inception of iPLEDGE regulations. [Extracted from the article]

Researchers at University Hospital Basel published a case report on a patient with Acute Promyelocytic Leukemia (APL) who was treated with isotretinoin instead of the standard therapy of all-trans retinoic acid (ATRA) in combination with arsenic trioxide (ATO). Despite a prescription error, the patient achieved stable complete remission, suggesting that isotretinoin could be effective in treating APL. The study highlights the potential of isotretinoin as a treatment option for APL, offering new insights into alternative therapies for this type of leukemia. [Extracted from the article]

A recent review conducted by researchers from Lazarski University in Warsaw, Poland, examines the relationship between isotretinoin, a vitamin A derivative used to treat severe acne, and the development of depression in patients undergoing treatment. Isotretinoin is known for its effectiveness in treating acne, but it is also associated with adverse effects, including psychiatric disorders such as depression. The review aims to critically examine existing research to clarify the potential risks of depression associated with isotretinoin use. The full article can be accessed for free through the provided link. [Extracted from the article]

A recent study from Rutgers University Robert Wood Johnson Medical School explores the relationship between acne and the cutaneous microbiome. The study aims to assess the effects of current acne treatments on the microbiome and explore implications for developing new therapies. The research found that the cutaneous microbiome plays a complex role in acne pathogenesis, with certain bacteria contributing to inflammation and dysbiosis. The study also highlights the potential of newer therapies, such as probiotics and plant extracts, to restore microbial balance. The findings emphasize the need for personalized approaches to acne management based on microbiome modulation. [Extracted from the article]

A recent report from the University of Colorado Anschutz Medical Campus discusses the findings of a study on acne fulminans (AF), a severe form of inflammatory acne commonly found in adolescents. AF is characterized by painful nodules and plaques that can progress to suppurative, ulcerative, and hemorrhagic lesions. The exact cause of AF is unknown, but it has been linked to certain medications and autoinflammatory syndromes. The most common presentation of AF is seen in adolescents starting isotretinoin therapy. The main treatment for AF is a combination of prednisone and isotretinoin, and early identification and treatment are crucial to minimize symptoms and scarring. Further research is needed to determine optimal management. [Extracted from the article]

A recent study conducted by researchers at the University of Warmia and Mazury in Olsztyn, Poland, aimed to evaluate the impact of lifestyle patterns on the occurrence and severity of adverse events (AEs) in patients with acne undergoing isotretinoin therapy. The study found that lifestyle factors such as physical activity, smoking, and eating habits did not affect the incidence and severity of AEs, indicating the safety of isotretinoin regardless of unhealthy habits. The researchers concluded that isotretinoin remains the most effective drug for acne treatment and should not be abandoned despite the AEs. This research has been peer-reviewed. [Extracted from the article]

A study conducted by researchers at Riphah International University in Faisalabad, Pakistan, explored the use of solid lipid nanoparticles (SLN) containing hyaluronic acid and tretinoin for the topical treatment of skin conditions. The researchers prepared and characterized the SLN formulation, confirming the incorporation of hyaluronic acid and tretinoin. Clinical studies on human volunteers showed that the SLN improved skin conditions, specifically reducing wrinkles, in 90% of participants after four weeks of treatment. The study suggests that hyaluronic acid has potential for the development of SLN for cosmetic formulations, particularly for skin applications. [Extracted from the article]

A new report from the University of Ioannina in Greece explores the effects of retinoids, a derivative of vitamin A, on the development of atherosclerosis. The research focuses on the role of retinoids in regulating vascular smooth muscle cells (VSMCs) and their impact on the proliferation, migration, and phenotypic switching of these cells. Studies have shown that retinoids have an inhibitory effect on VSMCs, leading to a reduction in atherosclerotic lesions. However, further research is needed to determine the safety and efficacy of retinoids in clinical practice. [Extracted from the article]

A recent study conducted by researchers at Guilan University of Medical Sciences in Iran examined the effects of isotretinoin treatment on the serum lipid profile of adolescents and adults with acne vulgaris. The study found that while there was a significant increase in cholesterol and LDL levels, there were no significant changes in HDL and triglyceride levels. The researchers concluded that although a low dose of isotretinoin can be used with minimal concern for changes in lipid profile, caution should be exercised in long-term follow-up and treatment. This information may be useful for individuals considering isotretinoin as a treatment option for acne vulgaris. [Extracted from the article]

A study conducted at the University of Alexandria in Egypt explored the effects of isotretinoin treatment on patients with acne vulgaris. The researchers found that isotretinoin treatment increased the expression of the transcription factor p53 in the skin and sebaceous glands of patients. This upregulation of p53 was associated with changes in gene expression related to the pathogenesis of acne vulgaris. The study suggests that increased p53-FoxO1 signaling caused by isotretinoin treatment may explain both the therapeutic effects and adverse effects of the drug. [Extracted from the article]

A recent study conducted at King Saud University in Saudi Arabia aimed to assess the extent of fetal exposure to isotretinoin, a medication used to treat severe acne, and evaluate adherence to risk minimization measures. The study included a cohort of 6,233 women of childbearing age who had received isotretinoin therapy between 2015 and 2020. The results showed a high incidence of fetal exposure to isotretinoin in Saudi Arabia, surpassing global estimates. The researchers emphasized the need for enhanced interventions and robust risk minimization strategies tailored to the specific challenges faced by the Saudi Arabian population. [Extracted from the article]

A recent case report from Hitit University discusses a rare adverse reaction to isotretinoin, a medication commonly used to treat acne vulgaris. The report describes a 21-year-old woman with acne vulgaris who developed acute eosinophilic pneumonia (AEP) after starting isotretinoin therapy. The patient experienced shortness of breath and lung CT imaging revealed lung infiltration. Isotretinoin therapy was discontinued and oral steroids were initiated, resulting in symptom improvement. The report suggests that hypersensitivity pneumonitis may be a potential complication of isotretinoin administration. [Extracted from the article]

A recent report from Yonsei University College of Dentistry highlights the idiosyncratic reactions associated with isotretinoin therapy, a widely used treatment for severe acne. The review emphasizes the importance of vigilant monitoring and appropriate management due to the potential adverse effects on multiple organ systems and bodily functions. The adverse effects range from psychiatric issues to hematological complications, gastrointestinal disturbances, cardiovascular effects, dermatological manifestations, hepatobiliary issues, ophthalmological changes, and orthopedic concerns. Healthcare professionals prescribing isotretinoin should be aware of these potential reactions and implement monitoring protocols to ensure patient safety and improve the quality of care. [Extracted from the article]

A recent study conducted by the University Hospital of Limerick in Ireland explored the potential association between sexual dysfunction and isotretinoin treatment for severe acne. While isotretinoin is considered the most effective treatment for severe acne, there have been rare reports of sexual dysfunction associated with its use. The study surveyed dermatologists in the UK and Ireland to gather their experiences and approaches to counseling and monitoring patients. The research found significant variance in counseling practices and opinions on the potential association between sexual adverse events and isotretinoin use. [Extracted from the article]

This document provides information about a Phase 3 clinical study conducted by Cutia Therapeutics(Wuxi)Co.,Ltd. The study aims to evaluate the effectiveness, safety, and immune response of CU-20101, a botulinum toxin type A, in treating moderate to severe glabellar lines. The study consists of two parts: a controlled study comparing CU-20101 with Botox, and an open-label study evaluating repeated injections of CU-20101. The study is currently recruiting participants in China and is projected to be completed by March 1, 2026. Contact details and eligibility criteria for participants are provided. [Extracted from the article]

A patent has been issued for topical compositions that can be used to treat dermatological disorders such as acne vulgaris and post-inflammatory hyperpigmentation (PIH). The compositions contain ingredients like arginine, salicylic acid, and azelaic acid, which help resolve the signs and symptoms of these skin conditions quickly and effectively. The compositions are stable and can be safely applied for extended periods of time. They can be administered topically in the form of creams, ointments, serums, suspensions, or solutions. These novel therapies provide a safe and rapid treatment option for individuals affected by dermatological disorders. [Extracted from the article]

A recent study conducted by researchers at the Department of Pharmaceutics and Pharmaceutical Technology explores strategies to reduce skin irritation caused by retinoids in topical formulations. Retinoids are known for their benefits in improving skin health, but they can also cause irritation. The study reviews various approaches to minimize this irritation, including developing drug delivery systems, adding ingredients with anti-irritation activity, improving the skin barrier, and increasing skin hydration. The findings suggest that these methods can effectively reduce retinoid-induced skin irritation. The study was published in Dermatology Research and Practice and can be accessed for free through the provided link. [Extracted from the article]

A recent study conducted at Hallym University Sacred Heart Hospital in South Korea has found a significant association between isotretinoin exposure and inflammatory bowel disease (IBD). Isotretinoin is commonly prescribed for acne treatment, but its link to IBD has been inconsistent in previous research. This nationwide case-control study analyzed data from the National Health Insurance Service database and found that isotretinoin exposure was associated with an increased risk of IBD, with a dose-response relationship. The researchers recommend that healthcare professionals consider alternative medications for acne treatment, especially in patients at a higher risk of developing IBD. [Extracted from the article]

Researchers at the Medical University of Lodz in Poland have conducted a study on the potential use of retinoids, which are derivatives of vitamin A, in cancer treatment. Retinoids have shown promise in controlling cellular processes related to cancer, such as proliferation, differentiation, and death. However, more research is needed to fully understand their effectiveness and potential combination with other therapies. The study highlights the importance of targeting endoplasmic reticulum stress as a potential treatment method for cancer. [Extracted from the article]