Search

The article discusses the molecular properties of RmlT, a wall teichoic acid rhamnosyltransferase that plays a role in modulating virulence in Listeria monocytogenes. The study highlights the importance of RmlT in transferring rhamnose to WTAs, which are essential for bacterial virulence and resistance to antimicrobials. The research suggests that targeting WTAs glycosyltransferases like RmlT could be a promising strategy for combating Gram-positive pathogens. [Extracted from the article]

A patent has been issued for a method of biosynthesizing diosmin and/or hesperidin in a microorganism. The current method of producing the medicament Daflon involves extracting flavonoids from orange peels and undergoing a chemical process to transform hesperidin into diosmin. However, this method is dependent on the availability of purified orange flavonoid extract, which can vary due to various factors. The inventors have developed a recombinant microorganism that contains specific nucleic acid sequences capable of producing diosmin and hesperidin. This alternative method could provide a more reliable and consistent supply of these compounds. [Extracted from the article]