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Researchers from the University of Tunis have conducted a study on the role of av integrins in neuroinflammation and demyelination, which are associated with neurodegenerative diseases like multiple sclerosis and Parkinson's disease. They used lebecetin, a protein derived from viper venom, to modulate av integrins in experimental models. The study found that lebecetin inhibited the upregulation of certain integrins and pro-inflammatory factors, and decreased the expression of phosphorylated NfkB. It also showed that lebecetin promoted remyelination in mice. These findings suggest that targeting av integrins could be a potential therapeutic approach for demyelinating diseases. [Extracted from the article]

Researchers from Mohammed VI Polytechnic University (UM6P) have explored the potential of snake venom-derived compounds for drug discovery in antiviral therapeutics. Snake venom contains bioactive compounds with diverse chemical structures and biological activities that have shown antiviral properties against viruses such as HIV, Coronaviridae, Flaviviridae, and Paramyxoviridae. While initial research has focused on Retroviridae (HIV) and Flaviviridae viruses, further investigation is needed to fully understand the potential of these compounds against other viruses and their mechanisms of action. This study suggests that snake venom-derived compounds hold promise for the development of novel antiviral therapeutics. [Extracted from the article]

Researchers from Suez Canal University in Egypt conducted a study to evaluate the oxidative stress and hematotoxic effects of the venom from the Egyptian Spitting Cobra (Naja nubiae) in rats. The study involved injecting different doses of the venom into rats and collecting blood samples at various time intervals for analysis. The results showed that the venom had dose-dependent effects on blood cells and caused significant alterations in hemoglobin concentration, packed cell volume, and the number of red blood cells. The venom also induced oxidative stress and disturbed the redox equilibrium in the rats. The researchers concluded that the venom's cytotoxicity could reduce antioxidant systems and lead to hematological alterations. [Extracted from the article]

Researchers from the Catholic University of Louvain (UCLouvain) in Belgium have conducted a study on lupus anticoagulant (LA) testing. They found that testing for LA should be approached with caution in the presence of inflammation, as it can lead to prolongation of both activated partial thromboplastin time and dilute Russell's viper venom clotting times. The study analyzed data from retrospective and prospective analyses, as well as in vitro experiments. The findings suggest that C-reactive protein (CRP), an acute phase protein associated with inflammation, can interfere with LA testing. This research provides valuable insights into the reliability of LA testing in the presence of inflammation. [Extracted from the article]

Scientists at the University of California, San Francisco (UCSF) and Contineum Therapeutics have developed a new drug called PIPE-307 that shows promise in reversing the damage caused by multiple sclerosis (MS). MS degrades the protective insulation around nerve cells, leading to problems with movement, balance, and vision. PIPE-307 targets a receptor on certain brain cells, prompting them to mature into myelin-producing cells that can replace the lost insulation. The drug has already passed a Phase I clinical trial and is currently being tested in Phase II with MS patients. If successful, it could transform how MS is treated. [Extracted from the article]

A study conducted by researchers at Capital Medical University in Beijing, China, explored the anti-inflammatory effects of batroxobin combined with anticoagulation in patients with cerebral venous thrombosis (CVT). The study found that batroxobin, in combination with anticoagulation, significantly decreased fibrinogen, platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), while increasing the proportion of patients with lower fibrinogen, neutrophil-lymphocyte ratio (NLR), PLR, and SII. The effect of batroxobin was found to be related to the number of episodes of administration. This study suggests that batroxobin may have additional benefits for CVT beyond reducing fibrinogen and indirect thrombolysis effects. [Extracted from the article]

A recent research report from the All India Institute of Medical Sciences (AIIMS) explores the topic of snakebite envenomation and its impact on public health in Southeast Asia. The study focuses on the adverse effects of anti-snake venom (ASV) treatment, specifically serum sickness, which can occur 5-14 days after treatment. The researchers present a case study of serum sickness in a patient treated with polyvalent ASV after a common krait envenomation, discussing its presentation, treatment, and potential prevention methods. This study provides valuable insights into an underexplored area of snakebite treatment. [Extracted from the article]

A recent preprint abstract discusses the potential protective effects of two novel custom peptides (CPs) inspired by snake venom on paraquat-induced neurodegenerative dysfunction in the Caenorhabditis elegans model. The CPs were found to prevent paraquat from binding to the nerve ring in C. elegans by binding to the tyrosine protein kinase receptor CAM 1. This resulted in a reduction in reactive oxygen species production, mitochondrial membrane depolarization, and chemosensory dysfunction. The CPs also inhibited dopaminergic neuron degeneration and alpha synuclein aggregation, which are hallmarks of Parkinson's Disease. Transcriptomic and proteomic analyses showed that the CPs prevented the increased expression of genes involved in oxidative stress, apoptosis, and neuronal damage. Importantly, the CPs did not exhibit toxicity or induce inflammatory mediators in a mouse model. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]

Researchers from the Federal University of ABC-UFABC in Sao Bernardo do Campo, Brazil, have conducted a review on the neuroprotective properties of oligopeptides derived from snake venom. The study found that certain peptides isolated from the venom of Viperidae family snakes have pro-survival properties, reduce oxidative stress, and promote cell viability and mitochondrial functions. The neuroprotection mediated by these snake venom oligopeptides is attributed to the activation of specific metabolic pathways and receptors. The research suggests that these small peptides show promise as neuroprotective agents for various neurodegenerative disorders. [Extracted from the article]

A recent study conducted by researchers at Manipal Academy of Higher Education in Karnataka, India, has discovered that a compound called 8-keto amyrin, isolated from the leaves of Cryptostegia grandiflora R. Br., can inhibit inflammation caused by Daboia russellii viper venom. The compound was found to directly bind to the active site of phospholipase A2 (PLA2), an enzyme involved in the production of inflammation mediators. The research suggests that 8-keto amyrin could be a potential candidate for the development of anti-inflammatory drugs. The study was supported by the Bioinformatics Resources & Applications Facility and C-DAC India, Pune HPC facility. [Extracted from the article]

A recent study conducted by researchers at the Molecular Biology and Protein Science Laboratory has examined the venom of the Trimeresurus erythrurus snake, also known as the Red-tailed bamboo pit viper. This snake species is responsible for a significant number of snakebite envenoming cases in Bangladesh, India, Myanmar, and Nepal. The study aimed to understand the toxicological properties and histological effects of the venom on mammalian organs. The researchers found that the venom contained various toxic components and induced significant pathological changes in organs such as the skin, skeletal muscle, lung, heart, kidney, and intestine. These findings provide valuable insights for the development of effective treatment strategies for complications resulting from T. erythrurus envenoming. [Extracted from the article]

A recent study conducted at the Federal University of ABC-UFABC in Sao Bernardo do Campo, Brazil, explored the potential therapeutic effects of a synthetic proline-rich oligopeptide 7a (PRO-7a) derived from Bothrops jararaca snake venom. The researchers investigated the cytoprotective effects of PRO-7a on oxidative stress-induced toxicity in neuronal PC12 cells and astrocyte-like C6 cells. The study found that PRO-7a exhibited neuroprotective effects in PC12 cells by reducing oxidative stress and restoring cell integrity, mitochondrial metabolism, ROS generation, and arginase indirect activity. The mechanism of action was found to be independent of the production of L-arginine metabolites and instead mediated through the activation of M1 muscarinic acetylcholine receptors. [Extracted from the article]

A study conducted by the Butantan Institute in Sao Paulo, Brazil, explores the role of snake venom disintegrins (SVDs) in angiogenesis, the formation of new blood vessels. The research highlights the dual roles of SVDs in angiogenesis, acting as both antiangiogenic agents by inhibiting integrin binding and proangiogenic agents by enhancing integrin binding. The study suggests that SVDs have potential therapeutic applications in diseases related to angiogenesis, such as cancer, ocular diseases, tissue regeneration, wound healing, and cardiovascular diseases. Further advancements in this field could lead to innovative treatments for these conditions. [Extracted from the article]

A study conducted by researchers at Pennsylvania State University (Penn State) College of Medicine and Milton S. Hershey Medical Center aimed to assess the impact of normalization on the lupus anticoagulant (LA) status in patients. The study compared the nonnormalized dilute Russell viper venom time (dRVVT) screen/confirm ratio (SCR) in patient plasma with the normalized SCR obtained using reference pooled plasma. The results showed that normalization did not change the lupus anticoagulant status and provided no clinical benefit in the patient population. The researchers concluded that normalization may be useful for intermethod and interlaboratory studies, but not for within-method LA detection. [Extracted from the article]

A recent report from Mohammed VI Polytechnic University (UM6P) highlights the potential therapeutic applications of snake venom. The study reveals that snake venom contains bioactive molecules with medicinal properties, including compounds like Bradykinin Potentiating Peptides (BPP) and Three-Finger Toxins (3FTx) that show promise in treating cardiovascular diseases and pain relief. Other components of snake venom, such as snake venom metalloproteinases (SVMP), L-amino acid oxidases (LAAO), and Phospholipase A2s (PLA2), are being explored for their potential in oncology treatments. The research also discusses the distribution of toxins across different snake species and suggests the use of Deep Learning (DL) for discovering new drug prospects from these toxins. [Extracted from the article]

A study conducted in Zhejiang, China, compared the effectiveness of treating sudden sensorineural hearing loss (SSNHL) with batroxobin alone versus a combination of batroxobin and intratympanic dexamethasone injection (ITDI). The study found that the combination treatment resulted in a higher total effective rate for SSNHL patients and showed potential for reducing peripheral blood inflammatory indicators and minimizing adverse reactions or complications. Both treatment groups experienced improvements in hearing, but the observation group had a significantly higher total effective rate. The study suggests that the combination treatment may enhance safety for SSNHL patients. [Extracted from the article]

A recent study conducted by the Federal University of Uberlandia in Brazil explored the potential therapeutic effects of a snake venom metalloprotease called BmooMP-a-I in treating Toxoplasma gondii-induced ileitis, a type of intestinal inflammation. The results showed that mice infected with T. gondii and treated with BmooMP-a-I exhibited improved survival rates, reduced inflammation in the intestine, and decreased production of inflammatory mediators. The researchers suggest that this alternative therapeutic agent has the potential to enhance the quality of life for patients suffering from inflammatory bowel diseases. The study has been peer-reviewed and published in Parasitology Research. [Extracted from the article]

Keywords: Biological Factors; Drugs and Therapies; Pharmacology; Snake Venoms EN Biological Factors Drugs and Therapies Pharmacology Snake Venoms 881 881 1 10/16/23 20231020 NES 231020 2023 OCT 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on pharmacology. Biological Factors, Drugs and Therapies, Pharmacology, Snake Venoms. [Extracted from the article]

Keywords: Biological Factors; Carboxylic Ester Hydrolases; Enzymes and Coenzymes; Phospholipases; Phosphoric Diester Hydrolases; Snake Venoms EN Biological Factors Carboxylic Ester Hydrolases Enzymes and Coenzymes Phospholipases Phosphoric Diester Hydrolases Snake Venoms 1122 1122 1 10/09/23 20231010 NES 231010 2023 OCT 10 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on phosphoric diester hydrolases. Biological Factors, Carboxylic Ester Hydrolases, Enzymes and Coenzymes, Phospholipases, Phosphoric Diester Hydrolases, Snake Venoms. [Extracted from the article]

Keywords: St. Lucia; Australia; Australia and New Zealand; Bioengineering; Biological Factors; Biomedical Engineering; Biomedicine; Biophysics; Biotechnology; Blood Proteins; Connective Tissue Cells; Fibrin; Fibroblasts; Health and Medicine; Snake Venoms; Tissue Engineering EN St. Lucia Australia Australia and New Zealand Bioengineering Biological Factors Biomedical Engineering Biomedicine Biophysics Biotechnology Blood Proteins Connective Tissue Cells Fibrin Fibroblasts Health and Medicine Snake Venoms Tissue Engineering 244 244 1 09/19/23 20230921 NES 230921 2023 SEP 21 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Current study results on Biomedical Engineering - Tissue Engineering have been published. St. Lucia, Australia, Australia and New Zealand, Bioengineering, Biological Factors, Biomedical Engineering, Biomedicine, Biophysics, Biotechnology, Blood Proteins, Connective Tissue Cells, Fibrin, Fibroblasts, Health and Medicine, Snake Venoms, Tissue Engineering. [Extracted from the article]

The cytoprotective effects of the peptide fraction (PF) from Bothrops jararaca snake venom were evaluated against oxidative stress changes in neuronal PC12 cells and astrocyte-like C6 cells." Keywords: Sao Bernardo do Campo; Brazil; South America; Life Science; Amino Acids; Arginine; Astrocytes; Basic Amino Acids; Biological Factors; Cells; Chromaffin Cells; Chromaffin System; Diamino Amino Acids; Essential Amino Acids; Neuroglia; Neurons; Nitric Oxide; Nitrogen Oxides; PC12 Cells; Peptides; Proteins; Proteomics; Risk and Prevention; Snake Venoms EN Sao Bernardo do Campo Brazil South America Life Science Amino Acids Arginine Astrocytes Basic Amino Acids Biological Factors Cells Chromaffin Cells Chromaffin System Diamino Amino Acids Essential Amino Acids Neuroglia Neurons Nitric Oxide Nitrogen Oxides PC12 Cells Peptides Proteins Proteomics Risk and Prevention Snake Venoms 3535 3535 1 08/21/23 20230825 NES 230825 2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Life Science. [Extracted from the article]

Keywords: Porto; Portugal; Europe; Biological Factors; Biological Toxins; Biomacromolecules; Chagas Disease; Euglenozoa Infections; Health and Medicine; Human Parasites; Leishmaniasis; Malaria; Mosquito-Borne Diseases; Parasitic Diseases and Conditions; Parasitic Skin Diseases and Conditions; Protozoan Infections; Protozoan Parasites; Snake Venoms; Venoms EN Porto Portugal Europe Biological Factors Biological Toxins Biomacromolecules Chagas Disease Euglenozoa Infections Health and Medicine Human Parasites Leishmaniasis Malaria Mosquito-Borne Diseases Parasitic Diseases and Conditions Parasitic Skin Diseases and Conditions Protozoan Infections Protozoan Parasites Snake Venoms Venoms 34 34 1 07/03/23 20230704 NES 230704 2023 JUL 4 (NewsRx) -- By a News Reporter-Staff News Editor at Zika & Mosquito Week -- Investigators discuss new findings in Mosquito-Borne Diseases - Malaria. Keywords for this news article include: Porto, Portugal, Europe, Biological Factors, Biological Toxins, Biomacromolecules, Chagas Disease, Euglenozoa Infections, Health and Medicine, Human Parasites, Leishmaniasis, Malaria, Mosquito-Borne Diseases, Parasitic Diseases and Conditions, Parasitic Skin Diseases and Conditions, Protozoan Infections, Protozoan Parasites, Snake Venoms, Venoms, University of Porto. [Extracted from the article]

According to the news reporters, the research concluded: "Russell's viper venom induced pulmonary thrombosis when injected intravenously in mice and thrombi in the microvasculature and affected skeletal muscle when administered locally. Keywords: Biological Factors; Cardiovascular Diseases and Conditions; Drugs and Therapies; Embolism and Thrombosis; Health and Medicine; Hematology; Snake Venoms; Thrombosis; Vascular Diseases and Conditions; Viper Venoms EN Biological Factors Cardiovascular Diseases and Conditions Drugs and Therapies Embolism and Thrombosis Health and Medicine Hematology Snake Venoms Thrombosis Vascular Diseases and Conditions Viper Venoms 366 366 1 07/03/23 20230703 NES 230703 2023 JUL 3 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Data detailed on thrombosis have been presented. [Extracted from the article]

Keywords: Biological Factors; Breast Cancer; Cancer; Enzymes and Coenzymes; Health and Medicine; Oncology; Peptide Hydrolases; Peptides and Proteins; Proteins; Proteome; Serine Endopeptidases; Snake Venoms; Trypsin; Women's Health EN Biological Factors Breast Cancer Cancer Enzymes and Coenzymes Health and Medicine Oncology Peptide Hydrolases Peptides and Proteins Proteins Proteome Serine Endopeptidases Snake Venoms Trypsin Women's Health 1458 1458 1 06/19/23 20230620 NES 230620 2023 JUN 20 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on breast cancer have been published. Bioactive peptide can be originated from isolated free peptide or produced by hydrolysis of protein." For more information on this research see: Proteome of monocled cobra (Naja kaouthia) venom and potent anti breast cancer peptide from trypsin hydrolyzate of the venom protein. [Extracted from the article]

For more information on this research see: Effects of C-terminal-ethyl-esterification In a Snake-venom-based Peptide Against the Neurotoxicity of Acrolein In Pc12 Cells. Keywords: Ribeirao Preto; Brazil; South America; Life Science; Acrolein; Aldehydes; Biological Factors; Chromaffin Cells; Chromaffin System; PC12 Cells; Risk and Prevention; Snake Venoms EN Ribeirao Preto Brazil South America Life Science Acrolein Aldehydes Biological Factors Chromaffin Cells Chromaffin System PC12 Cells Risk and Prevention Snake Venoms 4026 4026 1 05/08/23 20230512 NES 230512 2023 MAY 12 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Life Science. According to news reporting originating from Ribeirao Preto, Brazil, by NewsRx correspondents, research stated, "We have recently reported the neurotrophic and neuroprotective effects of the snake-venom-based synthetic tripeptide BTX-I in PC12 cells treated with acrolein. [Extracted from the article]

Keywords: Goa; India; Asia; Angiology; Biological Factors; Cancer; Disintegrins; Health and Medicine; Oncology; Peptides; Peptides and Proteins; Platelet Aggregation; Snake Venoms EN Goa India Asia Angiology Biological Factors Cancer Disintegrins Health and Medicine Oncology Peptides Peptides and Proteins Platelet Aggregation Snake Venoms 319 319 1 04/03/23 20230404 NES 230404 2023 APR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Cancer have been published. For more information on this research see: How Snake Venom Disintegrins Affect Platelet Aggregation and Cancer Proliferation. [Extracted from the article]

The amino acid sequence of Batroxin I was determined by de novo sequencing as < EKWPRPDAPIPP (where < E = pyroglutamic acid); hence, it is an unpublished peptide that belongs to the class of bradykinin-enhancing peptides and cell penetration peptide. Keywords: Ribeirao Preto; Brazil; South America; Biological Factors; Bradykinin; Intercellular Signaling Peptides and Proteins; Kinins; Neuropeptides; Oligopeptides; Peptides; Proteins; Snake Venoms EN Ribeirao Preto Brazil South America Biological Factors Bradykinin Intercellular Signaling Peptides and Proteins Kinins Neuropeptides Oligopeptides Peptides Proteins Snake Venoms 294 294 1 03/27/23 20230328 NES 230328 2023 MAR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Proteins - Neuropeptides is the subject of a report. [Extracted from the article]