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Researchers at the First Hospital of China Medical University conducted a study on bladder cancer, focusing on the role of stearoyl-CoA desaturase (SCD) in the disease. The study aimed to analyze the SCD transcription start site and explore the impact of SCD inhibitors on cancer stem cells. The research also highlighted the significance of nervonic acid in altering the proliferative capacity of bladder cancer cell lines. This study provides valuable insights into potential treatment strategies for bladder cancer. [Extracted from the article]

A recent study conducted at Chongqing Medical University in China explored the use of 6-gingerol, an active compound in ginger, to alleviate fructose-induced hepatic steatosis in rats. The research found that 6-gingerol reduced hyperlipidemia and inhibited de novo lipogenesis, targeting stearoyl-CoA desaturase (SCD) to decrease fatty acid desaturation levels. The study suggests that 6-gingerol may be a potential therapeutic option for metabolic-associated fatty liver disease. For more information, the full article can be accessed through the International Journal of Molecular Sciences. [Extracted from the article]

A study conducted at the Birla Institute of Technology and Science Pilani in India focused on Montelukast Therapy and its potential as a treatment for non-alcoholic fatty liver disease (NAFLD). The research identified Montelukast as a potential inhibitor of the SCD1 enzyme, which plays a role in fat accumulation in the liver. The study utilized virtual screening, molecular docking, and molecular dynamics simulations to identify potential inhibitors, with Montelukast showing promising results in reducing hepatic fat accumulation and oxidative stress. The findings suggest that Montelukast could be a valuable treatment option for metabolic disorders involving SCD1. [Extracted from the article]

A recent study conducted at the University of Wisconsin Madison has provided new insights into liver cancer. The research focused on the role of the enzyme Stearoyl-CoA desaturase-1 (SCD1) in liver damage, including fibrosis and hepatocellular carcinoma (HCC). The study found that deficiency of SCD1 in the liver led to increased saturation of liver lipid species and hepatic fibrosis. The research highlights the connection between monounsaturated fatty acid (MUFA) insufficiency and the development of fibrosis, cirrhosis, and HCC. [Extracted from the article]

This document is a patent application for a new method of treating Parkinson's disease. The application describes the use of a double stranded ribonucleic acid (dsRNA) agent that targets the Stearoyl-CoA Desaturase 5 (Scd5) gene. The dsRNA agent consists of a sense strand and an antisense strand, with the antisense strand being complementary to the target gene. The patent application provides detailed information on the specific nucleotide sequences, modifications, and conjugations that can be used in the dsRNA agent. The application also mentions the potential use of the dsRNA agent in treating Parkinson's disease and other movement disorders. [Extracted from the article]

A study conducted by researchers at Tabriz University of Medical Sciences examined the expression and activity of the enzyme stearoyl-CoA desaturase 1 (SCD1) in different breast cancer cell lines. The study found that the luminal A/B and triple-negative subtypes of breast cancer showed higher SCD1 expression and activity compared to the HER2-enriched subtype. These findings suggest differences in lipid metabolism among breast cancer subclasses and identify potential therapeutic targets for managing breast cancer. The study provides valuable insights into the unique conditions of the tumor microenvironment and the role of fatty acids in cancer cell energy supply. [Extracted from the article]

A recent study conducted at Lovely Professional University in Punjab, India, explores the potential of targeting the enzyme stearoyl-CoA desaturase (SCD) as a novel approach for diabetes therapy. The research suggests that lipid metabolism plays a crucial role in the development of insulin resistance, particularly in type 2 diabetes. By inhibiting SCD, it may be possible to manage diabetes more effectively. The study highlights the therapeutic potential of SCD inhibitors in the treatment of diabetes. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of cis-vaccenic acid (cVA) in prostate cancer. The study found that cVA, a monounsaturated fatty acid, is produced by the enzyme stearoyl CoA desaturase 1 (SCD1), which is frequently dysregulated in cancer. The researchers discovered that cVA promotes cell growth and rescues reductions in cell viability caused by SCD1 inhibition. This study highlights the importance of understanding the lipidome of cancer cells to better comprehend the molecular pathology of the disease. Please note that this preprint has not undergone peer review. [Extracted from the article]

A recent study explored the relationship between sleep disturbances, astrocytes, and lipid metabolism in Alzheimer's disease (AD). The study focused on the inhibition of stearoyl-CoA desaturase (SCD), an enzyme involved in lipid metabolism, and its effects on sleep and astrocytic function in a mouse model of AD. The results showed that while SCD inhibition did not restore sleep disturbances in the mice, it did reverse changes in astrocytes in the hippocampus. These findings contribute to our understanding of the pathophysiology of AD and its associated sleep disturbances. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]

Keywords: Breast Cancer; Breast Diseases and Conditions; Breast Tumors; Cancer; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Genetics; Health and Medicine; Oncology; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase; Women's Health EN Breast Cancer Breast Diseases and Conditions Breast Tumors Cancer Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Genetics Health and Medicine Oncology Oxidoreductases Oxygenases Stearoyl-CoA Desaturase Women's Health 1620 1620 1 11/06/23 20231109 NES 231109 2023 NOV 7 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on breast tumors are discussed in a new report. Understanding the role of adipose tissue (AT), as the main component of the breast tumor microenvironment (TME) in the development of cancer, is crucial for the early detection of breast cancer (BC).". [Extracted from the article]

Keywords: Warsaw; Poland; Europe; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Gastroenterology; Health and Medicine; Oxidoreductases; Oxygenases; Pancreas; Stearoyl-CoA Desaturase EN Warsaw Poland Europe Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Gastroenterology Health and Medicine Oxidoreductases Oxygenases Pancreas Stearoyl-CoA Desaturase 182 182 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Diabetes Week -- A new study on Enzymes and Coenzymes - Fatty Acid Desaturases is now available. Stearoyl-CoA desaturase 1 (SCD1) is critical for producing unsaturated fatty acyl moieties for fluent storage into and out of LDs, likely affecting the overall rate of beta-cell survival. [Extracted from the article]

The expression of various fatty acid metabolizing enzymes such as stearoyl-CoA desaturase 1 (SCD1) was altered in early-stage ovarian cancer tissue compared with that in normal ovarian tissue. Keywords: Biomarkers; Cancer; Desaturase; Diagnostics and Screening; Enzymes and Coenzymes; Fatty Acid Desaturases; Gynecology; Health and Medicine; Oncology; Ovarian Cancer; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase; Women's Health EN Biomarkers Cancer Desaturase Diagnostics and Screening Enzymes and Coenzymes Fatty Acid Desaturases Gynecology Health and Medicine Oncology Ovarian Cancer Oxidoreductases Oxygenases Stearoyl-CoA Desaturase Women's Health 1184 1184 1 09/11/23 20230912 NES 230912 2023 SEP 12 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Researchers detail new data in ovarian cancer. [Extracted from the article]

Preliminary small animal PET/CT imaging study showedhigh specific uptake and block of [C-11]SSI-4 uptake withco-injection of cold SSI-4 in high SCD1-expressing organs includinglacrimal gland, brown fat, liver, and tumor. Keywords: Jacksonville; State:Florida; United States; North and Central America; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase EN Jacksonville State:Florida United States North and Central America Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Oxidoreductases Oxygenases Stearoyl-CoA Desaturase 321 321 1 08/07/23 20230812 NES 230812 2023 AUG 7 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Current study results on Enzymes and Coenzymes - Fatty Acid Desaturases have been published. [Extracted from the article]

To assess the functional relevance of SCD2 in the macrophage response to infection, we challenged SCD2-deficient macrophages with uropathogenic Escherichia coli and found that there was impaired clearance of intracellular bacteria. Keywords: Connective Tissue Cells; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Health and Medicine; Immunology; Inflammation; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; Oxidoreductases; Oxygenases; Phagocytes; Stearoyl-CoA Desaturase EN Connective Tissue Cells Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Health and Medicine Immunology Inflammation Macrophages Mononuclear Phagocyte System Myeloid Cells Oxidoreductases Oxygenases Phagocytes Stearoyl-CoA Desaturase 1032 1032 1 07/24/23 20230728 NES 230728 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on fatty acid desaturases is now available. [Extracted from the article]

Keywords: Biomarkers; Cancer; Desaturase; Diagnostics and Screening; Drugs and Therapies; Enzymes and Coenzymes; Fatty Acid Desaturases; Genetics; Health and Medicine; Oncology; Oxidoreductases; Oxygenases; Pharmaceuticals; Stearoyl-CoA Desaturase; Stem Cell Research EN Biomarkers Cancer Desaturase Diagnostics and Screening Drugs and Therapies Enzymes and Coenzymes Fatty Acid Desaturases Genetics Health and Medicine Oncology Oxidoreductases Oxygenases Pharmaceuticals Stearoyl-CoA Desaturase Stem Cell Research 481 481 1 06/05/23 20230609 NES 230609 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Stem Cell Week -- New research on cancer is the subject of a new report. According to the news reporters, the research concluded: "In addition, the involvement of SCD1 in cancer stem cells has been observed in various types of cancer. [Extracted from the article]

Keywords: Cardiology; Cardiovascular; Cardiovascular Research; Desaturase; Enzymes and Coenzymes; Fatty Acid Desaturases; Health and Medicine; Oxidoreductases; Oxygenases; Stearoyl-CoA Desaturase EN Cardiology Cardiovascular Cardiovascular Research Desaturase Enzymes and Coenzymes Fatty Acid Desaturases Health and Medicine Oxidoreductases Oxygenases Stearoyl-CoA Desaturase 245 245 1 04/03/23 20230403 NES 230403 2023 APR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on fatty acid desaturases is the subject of a new report. According to news originating from Warsaw, Poland, by NewsRx editors, the research stated, "Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty acids." The loss of stearoyl-CoA desaturase 1 reduces fatty acid oxidation and increases glucose oxidation in the heart. [Extracted from the article]