12 results on '"Anderson Rob"'
Search Results
2. Remote monitoring for long-term physical health conditions: an evidence and gap map.
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de Bell, Siân, Zhivko Zhelev, Shaw, Naomi, Bethel, Alison, Anderson, Rob, and Coon, Jo Thompson
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- 2023
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3. Development and evaluation of a collaborative care intervention for male prison leavers with mental health problems: the Engager research programme.
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Byng, Richard, Lennox, Charlotte, Kirkpatrick, Tim, Quinn, Cath, Anderson, Rob, Brand, Sarah Louise, Callaghan, Lynne, Carroll, Lauren, Durcan, Graham, Gill, Laura, Goodier, Sara, Graham, Jonathan, Greer, Rebecca, Haddad, Mark, Harris, Tirril, Henley, William, Hunter, Rachael, Maguire, Mike, Leonard, Sarah, and Michie, Susan more...
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- 2022
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4. Experiences of children and young people from ethnic minorities in accessing mental health care and support: rapid scoping review.
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Coelho, Helen, Price, Anna, Kiff, Fraizer, Trigg, Laura, Robinson, Sophie, Coon, Jo Thompson, and Anderson, Rob
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- 2022
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5. Improving continence in children and young people with neurodisability: a systematic review and survey.
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Eke, Helen, Hunt, Harriet, Ball, Susan, Rogers, Morwenna, Whear, Rebecca, Allinson, Annette, Melluish, Julia, Lindsay, Claire, Richardson, Davina, Rogers, June, Hutton, Eve, Madden, Nicholas, Wright, Anne, Anderson, Rob, Logan, Stuart, Coon, Jo Thompson, and Morris, Christopher more...
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- 2021
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6. STOPP/START interventions to improve medicines management for people aged 65 years and over: a realist synthesis.
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Gangannagaripalli, Jaheeda, Porter, Ian, Davey, Antoinette, Cabello, Ignacio Ricci, Greenhalgh, Joanne, Anderson, Rob, Briscoe, Simon, Hughes, Carmel, Payne, Rupert, Cockcroft, Emma, Harris, Jim, Bramwell, Charlotte, and Valderas, Jose M. more...
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- 2021
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7. Synthesis for health services and policy: case studies in the scoping of reviews.
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Anderson, Rob, Booth, Andrew, Eastwood, Alison, Rodgers, Mark, Shaw, Liz, Coon, Jo Thompson, Briscoe, Simon, Cantrell, Anna, Chambers, Duncan, Goyder, Elizabeth, Nunns, Michael, Preston, Louise, Raine, Gary, and Thomas, Sian more...
- Published
- 2021
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8. The implementation of Safety Management Systems in healthcare: a systematic review and international comparison.
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Zhelev Z, de Bell S, Bethel A, Clarke M, Anderson R, and Coon JT
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- Humans, New Zealand, Australia, Canada, Delivery of Health Care organization & administration, Netherlands, Ireland, Leadership, Patient Safety standards, Safety Management organization & administration, Safety Management standards
- Abstract
Background: In health care, errors could have serious consequences for patients and staff. High-risk industries, such as aviation, have improved safety by taking a systems approach, known as safety management systems. Safety management systems are generally considered to have four key components: leadership commitment and safety policy; safety risk management; safety assurance; and safety culture. Safety management systems need to be context-specific to be effective. Evidence on the use of safety management systems in health care is therefore needed to inform policy decisions., Objectives: To investigate the application of safety management systems to patient safety in terms of effectiveness, implementation and experience., Methods: We conducted a systematic review of research and other evidence from high-income countries that have publicly funded healthcare systems with universal coverage and key evidence available in English. We included Australia, Canada, Ireland, New Zealand and the Netherlands. We searched the websites of, and contacted experts from, patient safety organisations in each country, and searched MEDLINE (December 2023) and EMBASE (via Ovid), Cumulative Index to Nursing and Allied Health Literature (EBSCO) and Web of Science (February 2024). We included policy documents, research and other evidence relating to the effectiveness, implementation or experience of the safety approach in each country. We summarised and mapped included evidence onto an initial framework based on analysis of safety management systems in high-risk industries. We shared drafts with experts in each country for comment. No standardised quality appraisal was conducted but those studies evaluating impact were critically examined for risk of bias., Results: Fifty-three publications were included, from Australia (5), Canada (7), Ireland (8), New Zealand (9) and the Netherlands (24). The Netherlands was the only country with a patient safety programme explicitly based on a safety management system approach. The programme was associated with improvement in some aspects of patient safety in hospitals but there was significant variation in its implementation and outcomes. The main components of a safety management system were also identified to some extent in the patient safety approaches of the other four countries, along with evidence of influence from high-risk industries and 'safety science' more widely., Limitations: Although we followed best practice for conducting systematic reviews, some limitations should be acknowledged. We did not conduct formal quality appraisal, but the risk of bias in studies evaluating impact was examined. We also tried to mitigate the risk of partial understanding (from the use of policy documents) by talking to experts from each country., Conclusions: Only the Dutch patient safety programme was explicitly based on a safety management system approach. Concepts from high-risk industries and broader safety science had influenced the patient safety approach in the other countries, and the ongoing approach in the Netherlands, but this was less systematic and explicit. Approaches to patient safety in all countries reflect increasing awareness that for an initiative to be successful, it needs to be context-specific., Future Work: Using realist methods to identify mechanisms underpinning the success of different patient safety approaches could allow better understanding of how and to what extent such initiatives work in specific circumstances. Methods for evaluation of impact also require further development to allow better understanding and comparison of different approaches., Study Registration: This study is registered as PROSPERO CRD42023487512., Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health and Social Care Delivery Research programme (NIHR award ref: NIHR136105) and is published in full in Health and Social Care Delivery Research ; Vol. 13, No. 7. See the NIHR Funding and Awards website for further award information. more...
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- 2025
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9. Interventions to improve the mental health of children and young people with long-term physical conditions: linked evidence syntheses.
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Moore DA, Nunns M, Shaw L, Rogers M, Walker E, Ford T, Garside R, Ukoumunne O, Titman P, Shafran R, Heyman I, Anderson R, Dickens C, Viner R, Bennett S, Logan S, Lockhart F, and Thompson Coon J
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- Adolescent, Child, Cost-Benefit Analysis, Humans, Social Support, Cognitive Behavioral Therapy, Mental Disorders diagnosis, Mental Disorders therapy, Qualitative Research, Randomized Controlled Trials as Topic
- Abstract
Background: Although mental health difficulties can severely complicate the lives of children and young people (CYP) with long-term physical conditions (LTCs), there is a lack of evidence about the effectiveness of interventions to treat them., Objectives: To evaluate the clinical effectiveness and cost-effectiveness of interventions aiming to improve the mental health of CYP with LTCs (review 1) and explore the factors that may enhance or limit their delivery (review 2)., Data Sources: For review 1, 13 electronic databases were searched, including MEDLINE, EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Science Citation Index. For review 2, MEDLINE, PsycINFO and CINAHL were searched. Supplementary searches, author contact and grey literature searches were also conducted., Review Methods: The first systematic review sought randomised controlled trials (RCTs) and economic evaluations of interventions to improve elevated symptoms of mental ill health in CYP with LTCs. Effect sizes for each outcome were calculated post intervention (Cohen's d ). When appropriate, random-effects meta-analyses produced pooled effect sizes ( d ). Review 2 located primary qualitative studies exploring experiences of CYP with LTCs, their families and/or practitioners, regarding interventions aiming to improve the mental health and well-being of CYP with LTCs. Synthesis followed the principles of metaethnography. An overarching synthesis integrated the findings from review 1 and review 2 using a deductive approach. End-user involvement, including topic experts and CYP with LTCs and their parents, was a feature throughout the project., Results: Review 1 synthesised 25 RCTs evaluating 11 types of intervention, sampling 12 different LTCs. Tentative evidence from seven studies suggests that cognitive-behavioural therapy interventions could improve the mental health of CYP with certain LTCs. Intervention-LTC dyads were diverse, with few opportunities to meta-analyse. No economic evaluations were located. Review 2 synthesised 57 studies evaluating 21 types of intervention. Most studies were of individuals with cancer, a human immunodeficiency virus (HIV) infection or mixed LTCs. Interventions often aimed to improve broader mental health and well-being, rather than symptoms of mental health disorder. The metaethnography identified five main constructs, described in an explanatory line of argument model of the experience of interventions. Nine overarching synthesis categories emerged from the integrated evidence, raising implications for future research., Limitations: Review 1 conclusions were limited by the lack of evidence about intervention effectiveness. No relevant economic evaluations were located. There were no UK studies included in review 1, limiting the applicability of findings. The mental health status of participants in review 2 was usually unknown, limiting comparability with review 1. The different evidence identified by the two systematic reviews challenged the overarching synthesis., Conclusions: There is a relatively small amount of comparable evidence for the effectiveness of interventions for the mental health of CYP with LTCs. Qualitative evidence provided insight into the experiences that intervention deliverers and recipients valued. Future research should evaluate potentially effective intervention components in high-quality RCTs integrating process evaluations. End-user involvement enriched the project., Study Registration: This study is registered as PROSPERO CRD42011001716., Funding: The National Institute for Health Research (NIHR) Health Technology Assessment programme and the NIHR Collaboration for Leadership in Applied Health Research and Care South West Peninsula., Competing Interests: Roz Shafran is on the Health Technology Assessment Mental, Psychological and Occupational Health Panel and Stuart Logan is on the Open Call Assessment Board – Medicines for Children. more...
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- 2019
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10. Enhanced psychological care in cardiac rehabilitation services for patients with new-onset depression: the CADENCE feasibility study and pilot RCT.
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Richards SH, Campbell JL, Dickens C, Anderson R, Gandhi M, Gibson A, Kessler D, Knight L, Kuyken W, Richards DA, Taylor RS, Turner K, Ukoumunne OC, Davey A, Warren FC, Winder RE, and Wright CA
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- Aged, Aged, 80 and over, Cardiac Rehabilitation nursing, Cardiovascular Nursing organization & administration, Feasibility Studies, Female, Health Resources economics, Health Resources statistics & numerical data, Health Status, Humans, Male, Mental Health, Mental Health Services organization & administration, Middle Aged, Patient Satisfaction, Pilot Projects, Qualitative Research, Quality of Life, Severity of Illness Index, Socioeconomic Factors, United Kingdom, Acute Coronary Syndrome complications, Acute Coronary Syndrome rehabilitation, Cardiac Rehabilitation methods, Depression etiology, Depression therapy
- Abstract
Background: Around 19% of people screened by UK cardiac rehabilitation programmes report having moderate or severe symptoms of depression. These individuals are at an increased risk of cardiac mortality and morbidity, reduced quality of life and increased use of health resources compared with their non-depressed counterparts. Maximising psychological health is a goal of cardiac rehabilitation, but psychological care is patchy., Objective(s): To examine the feasibility and acceptability of embedding enhanced psychological care (EPC) within cardiac rehabilitation, we tested the feasibility of developing/implementing EPC and documented the key uncertainties associated with undertaking a definitive evaluation., Design: A two-stage multimethods study; a feasibility study and a qualitative evaluation, followed by an external pilot cluster randomised controlled trial (RCT) with a nested qualitative study., Setting: UK comprehensive cardiac rehabilitation teams., Participants: Adults eligible for cardiac rehabilitation following an acute coronary syndrome with new-onset depressive symptoms on initial nurse assessment. Patients who had received treatment for depression in the preceding 6 months were excluded., Interventions: The EPC intervention comprised nurse-led mental health-care co-ordination and behavioural activation within cardiac rehabilitation. The comparator was usual cardiac rehabilitation care., Main Outcome Measures: Measures at baseline, and at the 5- (feasibility and pilot) and 8-month follow-ups (pilot only). Process measures related to cardiac team and patient recruitment, and participant retention. Outcomes included depressive symptoms, cardiac mortality and morbidity, anxiety, health-related quality of life and service resource use. Interviews explored participant and nurses' views and experiences., Results: Between September 2014 and May 2015, five nurses from four teams recruited participants into the feasibility study. Of the 203 patients screened, 30 were eligible and nine took part (the target was 20 participants). At interview, participants and nurses gave valuable insights into the EPC intervention design and delivery. Although acceptable, the EPC delivery was challenging for nurses (e.g. the ability to allocate sufficient time within existing workloads) and the intervention was modified accordingly. Between December 2014 and February 2015, 8 out of 20 teams approached agreed to participate in the pilot RCT [five were randomised to the EPC arm and three were randomised to the usual-care (UC) arm]. Of the 614 patients screened, 55 were eligible and 29 took part (the target was 43 participants). At baseline, the trial arms were well matched for sex and ethnicity, although the EPC arm participants were younger, from more deprived areas and had higher depression scores than the UC participants. A total of 27 out of 29 participants were followed up at 5 months. Interviews with 18 participants (12 in the EPC arm and six in the UC arm) and seven nurses who delivered EPC identified that both groups acknowledged the importance of receiving psychological support embedded within routine cardiac rehabilitation. For those experiencing/delivering EPC, the intervention was broadly acceptable, albeit challenging to deliver within existing care., Limitations: Both the feasibility and the pilot studies encountered significant challenges in recruiting patients, which limited the power of the pilot study analyses., Conclusions: Cardiac rehabilitation nurses can be trained to deliver EPC. Although valued by both patients and nurses, organisational and workload constraints were significant barriers to implementation in participating teams, suggesting that future research may require a modified approach to intervention delivery within current service arrangements. We obtained important data informing definitive research regarding participant recruitment and retention, and optimal methods of data collection., Future Research: Consideration should be given to the delivery of EPC by dedicated mental health practitioners, working closely with cardiac rehabilitation services., Trial Registration: Current Controlled Trials ISRCTN34701576., Funding: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment ; Vol. 22, No. 30. See the NIHR Journals Library website for further project information., Competing Interests: Rob Anderson contributes to the work of the National Institute for Health Research (NIHR) Health Services and Delivery Research (HSDR) programme as an unpaid member of their funding advisory panel (a researcher-led funding stream). Rod S Taylor is the chairperson of the NIHR HSDR researcher-led panel, a member of the Health Technology Assessment (HTA) Efficient Study Designs Board, the NIHR Priority Research Advisory Methodology Group, the HTA General Board, the HTA Themed Call, the Core Group of Methodological Experts for the NIHR Programme Grants for Applied Research programme and the HSDR Commissioning Board (commissioned and researcher led). Willem Kuyken receives royalties from the publication of Kuyken W, Padesky CA, Dudley R, Collaborative Case Conceptualization, New York, NY: Guildford Press; 2011, outside the submitted work. more...
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- 2018
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11. Immunosuppressive therapy for kidney transplantation in adults: a systematic review and economic model.
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Jones-Hughes T, Snowsill T, Haasova M, Coelho H, Crathorne L, Cooper C, Mujica-Mota R, Peters J, Varley-Campbell J, Huxley N, Moore J, Allwood M, Lowe J, Hyde C, Hoyle M, Bond M, and Anderson R
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- Abatacept economics, Abatacept therapeutic use, Antibodies, Monoclonal, Antilymphocyte Serum, Basiliximab, Bayes Theorem, Cost-Benefit Analysis, Everolimus economics, Everolimus therapeutic use, Graft Rejection prevention & control, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents adverse effects, Models, Economic, Mycophenolic Acid economics, Mycophenolic Acid therapeutic use, Quality of Life, Quality-Adjusted Life Years, Randomized Controlled Trials as Topic, Recombinant Fusion Proteins, Sirolimus economics, Sirolimus therapeutic use, Tacrolimus economics, Tacrolimus therapeutic use, Technology Assessment, Biomedical, Immunosuppressive Agents economics, Immunosuppressive Agents therapeutic use, Kidney Failure, Chronic surgery, Kidney Transplantation methods
- Abstract
Background: End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation, followed by immunosuppressive therapy (induction and maintenance therapy) to reduce the risk of kidney rejection and prolong graft survival., Objectives: To review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect(®), Novartis Pharmaceuticals UK Ltd) and rabbit anti-human thymocyte immunoglobulin (rATG) (Thymoglobulin(®), Sanofi) as induction therapy, and immediate-release tacrolimus (TAC) (Adoport(®), Sandoz; Capexion(®), Mylan; Modigraf(®), Astellas Pharma; Perixis(®), Accord Healthcare; Prograf(®), Astellas Pharma; Tacni(®), Teva; Vivadex(®), Dexcel Pharma), prolonged-release tacrolimus (Advagraf(®) Astellas Pharma), belatacept (BEL) (Nulojix(®), Bristol-Myers Squibb), mycophenolate mofetil (MMF) (Arzip(®), Zentiva; CellCept(®), Roche Products; Myfenax(®), Teva), mycophenolate sodium (MPS) (Myfortic(®), Novartis Pharmaceuticals UK Ltd), sirolimus (SRL) (Rapamune(®), Pfizer) and everolimus (EVL) (Certican(®), Novartis) as maintenance therapy in adult renal transplantation., Methods: Clinical effectiveness searches were conducted until 18 November 2014 in MEDLINE (via Ovid), EMBASE (via Ovid), Cochrane Central Register of Controlled Trials (via Wiley Online Library) and Web of Science (via ISI), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects and Health Technology Assessment (The Cochrane Library via Wiley Online Library) and Health Management Information Consortium (via Ovid). Cost-effectiveness searches were conducted until 18 November 2014 using a costs or economic literature search filter in MEDLINE (via Ovid), EMBASE (via Ovid), NHS Economic Evaluation Database (via Wiley Online Library), Web of Science (via ISI), Health Economic Evaluations Database (via Wiley Online Library) and the American Economic Association's electronic bibliography (via EconLit, EBSCOhost). Included studies were selected according to predefined methods and criteria. A random-effects model was used to analyse clinical effectiveness data (odds ratios for binary data and mean differences for continuous data). Network meta-analyses were undertaken within a Bayesian framework. A new discrete time-state transition economic model (semi-Markov) was developed, with acute rejection, graft function (GRF) and new-onset diabetes mellitus used to extrapolate graft survival. Recipients were assumed to be in one of three health states: functioning graft, graft loss or death., Results: Eighty-nine randomised controlled trials (RCTs), of variable quality, were included. For induction therapy, no treatment appeared more effective than another in reducing graft loss or mortality. Compared with placebo/no induction, rATG and BAS appeared more effective in reducing biopsy-proven acute rejection (BPAR) and BAS appeared more effective at improving GRF. For maintenance therapy, no treatment was better for all outcomes and no treatment appeared most effective at reducing graft loss. BEL + MMF appeared more effective than TAC + MMF and SRL + MMF at reducing mortality. MMF + CSA (ciclosporin), TAC + MMF, SRL + TAC, TAC + AZA (azathioprine) and EVL + CSA appeared more effective than CSA + AZA and EVL + MPS at reducing BPAR. SRL + AZA, TAC + AZA, TAC + MMF and BEL + MMF appeared to improve GRF compared with CSA + AZA and MMF + CSA. In the base-case deterministic and probabilistic analyses, BAS, MMF and TAC were predicted to be cost-effective at £20,000 and £30,000 per quality-adjusted life-year (QALY). When comparing all regimens, only BAS + TAC + MMF was cost-effective at £20,000 and £30,000 per QALY., Limitations: For included trials, there was substantial methodological heterogeneity, few trials reported follow-up beyond 1 year, and there were insufficient data to perform subgroup analysis. Treatment discontinuation and switching were not modelled., Future Work: High-quality, better-reported, longer-term RCTs are needed. Ideally, these would be sufficiently powered for subgroup analysis and include health-related quality of life as an outcome., Conclusion: Only a regimen of BAS induction followed by maintenance with TAC and MMF is likely to be cost-effective at £20,000-30,000 per QALY., Study Registration: This study is registered as PROSPERO CRD42014013189., Funding: The National Institute for Health Research Health Technology Assessment programme. more...
- Published
- 2016
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12. Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation.
- Author
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Haasova M, Snowsill T, Jones-Hughes T, Crathorne L, Cooper C, Varley-Campbell J, Mujica-Mota R, Coelho H, Huxley N, Lowe J, Dudley J, Marks S, Hyde C, Bond M, and Anderson R
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- Abatacept therapeutic use, Antibodies, Monoclonal economics, Antibodies, Monoclonal therapeutic use, Antilymphocyte Serum therapeutic use, Azathioprine economics, Azathioprine therapeutic use, Basiliximab, Child, Clinical Trials as Topic, Cost-Benefit Analysis, Drug Therapy, Combination, Everolimus therapeutic use, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents adverse effects, Models, Economic, Mycophenolic Acid therapeutic use, Recombinant Fusion Proteins economics, Recombinant Fusion Proteins therapeutic use, Sirolimus therapeutic use, Tacrolimus economics, Tacrolimus therapeutic use, Technology Assessment, Biomedical, Immunosuppressive Agents economics, Immunosuppressive Agents therapeutic use, Kidney Failure, Chronic surgery, Kidney Transplantation methods
- Abstract
Background: End-stage renal disease is a long-term irreversible decline in kidney function requiring kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation followed by induction and maintenance immunosuppressive therapy to reduce the risk of kidney rejection and prolong graft survival., Objectives: To systematically review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect,(®) Novartis Pharmaceuticals) and rabbit antihuman thymocyte immunoglobulin (Thymoglobuline,(®) Sanofi) as induction therapy and immediate-release tacrolimus [Adoport(®) (Sandoz); Capexion(®) (Mylan); Modigraf(®) (Astellas Pharma); Perixis(®) (Accord Healthcare); Prograf(®) (Astellas Pharma); Tacni(®) (Teva); Vivadex(®) (Dexcel Pharma)], prolonged-release tacrolimus (Advagraf,(®) Astellas Pharma); belatacept (BEL) (Nulojix,(®) Bristol-Myers Squibb), mycophenolate mofetil (MMF) [Arzip(®) (Zentiva), CellCept(®) (Roche Products), Myfenax(®) (Teva), generic MMF is manufactured by Accord Healthcare, Actavis, Arrow Pharmaceuticals, Dr Reddy's Laboratories, Mylan, Sandoz and Wockhardt], mycophenolate sodium, sirolimus (Rapamune,(®) Pfizer) and everolimus (Certican,(®) Novartis Pharmaceuticals) as maintenance therapy in children and adolescents undergoing renal transplantation., Data Sources: Clinical effectiveness searches were conducted to 7 January 2015 in MEDLINE (via Ovid), EMBASE (via Ovid), Cochrane Central Register of Controlled Trials (via Wiley Online Library) and Web of Science [via Institute for Scientific Information (ISI)], Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects and Health Technology Assessment (HTA) (The Cochrane Library via Wiley Online Library) and Health Management Information Consortium (via Ovid). Cost-effectiveness searches were conducted to 15 January 2015 using a costs or economic literature search filter in MEDLINE (via Ovid), EMBASE (via Ovid), NHS Economic Evaluation Databases (via Wiley Online Library), Web of Science (via ISI), Health Economic Evaluations Database (via Wiley Online Library) and EconLit (via EBSCOhost)., Review Methods: Titles and abstracts were screened according to predefined inclusion criteria, as were full texts of identified studies. Included studies were extracted and quality appraised. Data were meta-analysed when appropriate. A new discrete time state transition economic model (semi-Markov) was developed; graft function, and incidences of acute rejection and new-onset diabetes mellitus were used to extrapolate graft survival. Recipients were assumed to be in one of three health states: functioning graft, graft loss or death., Results: Three randomised controlled trials (RCTs) and four non-RCTs were included. The RCTs only evaluated BAS and tacrolimus (TAC). No statistically significant differences in key outcomes were found between BAS and placebo/no induction. Statistically significantly higher graft function (p < 0.01) and less biopsy-proven acute rejection (odds ratio 0.29, 95% confidence interval 0.15 to 0.57) was found between TAC and ciclosporin (CSA). Only one cost-effectiveness study was identified, which informed NICE guidance TA99. BAS [with TAC and azathioprine (AZA)] was predicted to be cost-effective at £20,000-30,000 per quality-adjusted life year (QALY) versus no induction (BAS was dominant). BAS (with CSA and MMF) was not predicted to be cost-effective at £20,000-30,000 per QALY versus no induction (BAS was dominated). TAC (with AZA) was predicted to be cost-effective at £20,000-30,000 per QALY versus CSA (TAC was dominant). A model based on adult evidence suggests that at a cost-effectiveness threshold of £20,000-30,000 per QALY, BAS and TAC are cost-effective in all considered combinations; MMF was also cost-effective with CSA but not TAC., Limitations: The RCT evidence is very limited; analyses comparing all interventions need to rely on adult evidence., Conclusions: TAC is likely to be cost-effective (vs. CSA, in combination with AZA) at £20,000-30,000 per QALY. Analysis based on one RCT found BAS to be dominant, but analysis based on another RCT found BAS to be dominated. BAS plus TAC and AZA was predicted to be cost-effective at £20,000-30,000 per QALY when all regimens were compared using extrapolated adult evidence. High-quality primary effectiveness research is needed. The UK Renal Registry could form the basis for a prospective primary study., Study Registration: This study is registered as PROSPERO CRD42014013544., Funding: The National Institute for Health Research HTA programme. more...
- Published
- 2016
- Full Text
- View/download PDF
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