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The Chinese Qingyu pig is a typical domestic fatty pig breed and an invaluable indigenous genetic resource in China. Compared with the Landrace pig, the Qingyu pig has unique meat characteristics, including muscle development, intramuscular fat, and other meat quality traits. At present, few studies have explored epigenetic differences due to DNA methylation between the Qingyu pig and the Landrace pig. In this study, 30 Qingyu pigs and 31 Landrace pigs were subjected to reduced representation bisulfite sequencing (RRBS). Genome-wide differential DNA methylation analysis was conducted. Six genomic regions, including regions on Sus scrofa chromosome (SSC) 1: 266.09-274.23 Mb, SSC5: 0.88-10.68 Mb, SSC8: 41.23-48.51 Mb, SSC12: 45.43-54.38 Mb, SSC13: 202.15-207.95 Mb, and SSC14: 126.43-139.85 Mb, were regarded as key regions that may be associated with phenotypic differences between the Qingyu pig and the Landrace pig. Furthermore, according to further analysis, five differentially methylated genes (ADCY1, FUBP3, GRIN2B, KIT, and PIK3R6) were identified as key candidate genes that might be associated with meat characteristics. Our findings provide new insights into the differences in DNA methylation between the Qingyu pig and the Landrace pig. These results enrich the epigenetic research of the Chinese Qingyu pig. Key words: DNA methylation, reduced representation bisulfite sequencing, Qingyu pig, Landrace pig. La race porcine chinoise Qingyu est une race domestique typique a forte teneur en gras et constitue une precieuse ressource genetique indigene en Chine. Compare au porc Landrace, le Qingyu presente des caracteristiques uniques au niveau de sa viande, dont le developpement du muscle, le gras intramusculaire et d'autres aspects de la qualite de la viande. A ce jour, peu d'etudes ont explore les differences epigenetiques due a la methylation de l'ADN entre les races Qingyu et Landrace. Dans ce travail, 30 porcs Qingyu et 31 porcs Landrace ont ete examines au moyen de sequencage au bisulfite d'une representation reduite du genome (RRBS). Une analyse pangenomique de la methylation differentielle a ete realisee. Six regions du genome du Sus scrofa (SSC1 : 266.09-274.23 Mb, SSC5 : 0.88-10.68 Mb, SSC8 : 41.23-48.51 Mb, SSC12 : 45.43-54.38 Mb, SSC13 : 202.15-207.95 Mb et SSC14 : 126.43-139.85 Mb) ont ete trouvees comme etant des regions cles possiblement associees aux differences phenotypiques entre les races Qingyu et Landrace. De plus, sur la base d'analyses plus approfondies, cinq genes affichant une methylation differentielle (ADCY1, FUBP3, GRIN2B, KIT, PIK3R6) sont presentes comme etant des genes cles associes aux caracteristiques de la viande. Ces resultats apportent un nouvel eclairage sur les differences de methylation de l'ADN entre les races Qingyu et Landrace. Ces travaux viennent alimenter la recherche epigenetique sur les porcs chinois Qingyu. [Traduit par la Redaction] Mots-cles : methylation de l'ADN, sequencage bisulfite a representation reduite, porcs Qingyu, porc Landrace., Introduction Pork is an important meat resource. The average intake of meat, especially pork, has continued to increase in China (He et al. 2016). The Qingyu pig is a typical [...]