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Relevance. To date, no detailed analysis of the variants of the pathogen circulating at different times on the territory of the Omsk region has been carried out.Aim. Comparative analysis of the diversity of circulating variants of SARS­CoV­-2 based on molecular genetic data, determine the lines and time of their appearance, compare the data obtained with data from the GISAID database.Materials and methods. Genome­wide sequencing of 222 primary and 5 culture (passages on Vero E6 and SPEV cell cultures) samples of SARS­-CoV­-2 from the Omsk region, collected from April 2020 to February 2022, on Oxford Nanopore Technologies and Illumina platforms, was carried out. Genetic lines were determined in Pangolin. The analysis was performed in MEGA7 and BioEdit.Results. 227 genome­wide SARS­-CoV­-2 sequences were obtained. 222 genomes have been uploaded to the GISAID database. The lines to which the samples belong were determined, phylogenetic trees were constructed for various regions of the SARS-CoV­-2 genome, the levels of virus homology were assessed and mutations in the S­protein region were analyzed.Conclusions. According to the data obtained, it is possible to roughly judge the time of the appearance of a particular variant, its consolidation and distribution in the population, and observe the rare mutations and the circulation of some rare lines. To assess the possibility of significant geographically linked changes in the SARS­-CoV­-2 in the Omsk region, the data obtained are insufficient. Virus variants circulating in the region are grouped into one cluster with identical variants from other regions or countries. A more pronounced intracluster differentiation of the lines can be observed when analyzing the RBD region. The situation with COVID­-19 in the Omsk region generally coincides with that in the whole country and the world. However, this does not exclude the parallel occurrence of certain mutations in remote territories from each other.

The purpose of this study is to assess the dynamics of the incidence of prostate cancer in the Omsk region for the period 2006– 2017. Materials and methods. A retrospective epidemiological analysis of data from statistical reports (Form No. 7) of the Omsk Oblast health authorities for the period 2006–2017 was carried out. Results and its discussion. In the structure of oncological morbidity in the male population of the Omsk Region, the proportion of prostate cancer was 16.3% and was lower than the average Russian average (17%). In rural areas, compared with the regional center, higher rates of increase in the incidence of prostate cancer were observed (by 1.2 times). In general, the situation on the territory of the Omsk Region is similar to the global trend, characterized by an increase in the incidence of the male population of prostate cancer, which is a reflection of insufficient attention to primary cancer prevention, features of the socio-economic situation in the Russian Federation. Findings. 1. In the long-term dynamics of incidence of prostate cancer in the region for the period 2006–2017. there was a moderately pronounced upward trend in indicators (Tpr. = 3.94%; p < 0.05), with higher growth rates (1.2 times) in rural areas compared to the regional center (respectively, 3.56% and 3.04%; p < 0.001). 2. From 2006 to 2017 incidence of prostate cancer in the Omsk region increased 2.3 times in total (from 29.2 to 66.2 per 100 ths) and 1.8 times in standardized indicators (from 24.8 to 44.4 per 100 ths). 3. Despite the obvious relevance of the pathology, the prevalence of known risk factors for the development of prostate cancer in the Omsk Region has not been studied sufficiently, which requires scientific justification and improvement of approaches to primary prevention with regard to regional characteristics.

The paper estimates the prevalence of the main risk factors for breast cancer (BC) in different age groups of the female population of the Omsk Region. Priority groups for the correction of risk factors in five age intervals were identified. According to the results of an integrated assessment of the aggregate of risk factors at different ages of women, the age group 60-69 years old was in the first ranking place for the priority of preventive measures, the second group was 70 years or more, the third group included a group of 30-39 year old women. The specific weight of the corrected risk factors in this group of respondents was 85.7%, which determines the potential of preventive measures.

The paper presents the epidemiological characteristics of diseases of the female population of the Omsk region of breast cancer (BC) from 2003 to 2012, Determined the dynamics of morbidity. A comparative analysis of breast cancer incidence rates in urban and rural residents of the area. In the structure of malignant tumors of the female population of the Omsk region the proportion of breast cancer was 23.3% and was lower than the national average (20.0%). In rural areas, compared with the regional center had higher growth rates of incidence of breast cancer (1.5-fold).

The paper shows the possibility of assessment of individual risk of developing breast cancer in women using an algorithm based on Bayes ' theorem. An epidemiological study (such as "case-control"), the prevalence of known risk factors for breast cancer in the female population of the Omsk region (n = 1002). The estimation of informativenes of risk factors for breast cancer signs and in terms of the likelihood ratio. Defined sensitivity and specificity of the proposed diagnostic test.