1. Pulse Wave Analysis in Children with Glomerulopathies
- Author
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Maria Roszkowska-Blaim, Zofia Wawer, and Piotr Skrzypczyk
- Subjects
medicine.medical_specialty ,business.industry ,Diastole ,Renal function ,medicine.disease ,Nephropathy ,Pulse pressure ,Endocrinology ,Blood pressure ,Internal medicine ,Heart rate ,Membranoproliferative glomerulonephritis ,Arterial stiffness ,Cardiology ,Medicine ,business - Abstract
Sympathetic activation, hypertension, hyperlipidemia, and immunosuppressive treatment are risk factors for vascular damage in children with glomerulopathies. Aim: To perform pulse wave analysis in children with glomerulopathies. Material and Methods: We studied 33 children (22â, 11â) aged 13.3 ± 3.9 years with glomerulopathies: Henoch-Schonlein nephropathy 9 patients, IgA nephropathy 7 patients, membranoproliferative glomerulonephritis 4 patients, mesangioproliferative glomerulonephritis 3 patients, minimal change disease 3 patients, focal segmental glomerulosclerosis (FSGS) 3 patients, and other nephropathies 4 patients. We evaluated age at the disease onset, development of hypertension, body mass index (BMI) Z-score, selected biochemical variables, glomerular filtration rate (ac. to Schwartz formula), and pulse wave parameters determined using a SphygmoCor device (AtCor Medical, Australia): aortic systolic pressure (AoSP), diastolic pressure (AoDP) and pulse pressure (AoPP), augmentation pressure (AP), augmentation index (AIx), augmentation index corrected for heart rate of 75 beats per minute (AIx-75HR) [%], and an index of myocardial oxygen supply and demand, subendocardial viability ratio (SEVR) [%]. The control group included 20 healthy children matched for age and gender. Results: Children with glomerulopathies showed trends for higher mean AP (P=0.08) and AIx (P=0.07), and a significantly higher mean AIx-75HR (P
- Published
- 2013
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