1. Diffractive-optics-based sensor as a tool for detection of biocompatibility of titanium and titanium-doped hydrocarbon samples
- Author
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Silvennoinen, Raimo, Hason, Stanislav, Vetterl, Vladimir, Penttinen, Niko, Silvennoinen, Martti, Myller, Kari, Cernochova, Pavlina, Bartakova, Sonia, Prachar, Patrik, and Cvrcek, Ladislav
- Subjects
Chemical detectors -- Design and construction ,Chemical detectors -- Technology application ,Diffraction -- Research ,Hydrocarbons -- Chemical properties ,Hydrocarbons -- Composition ,Hydrocarbons -- Identification and classification ,Titanium compounds -- Chemical properties ,Titanium compounds -- Identification and classification ,Technology application ,Astronomy ,Physics - Abstract
Adsorption of the elongated human plasma fibrinogen (HPF) and globular human serum albumin molecules on a titanium-based surface is monitored by analyzing permittivity and optical roughness of protein-modified surfaces by using a diffractive optical element (DOE)-based sensor and variable angle spectro-ellipsometry (VASE). Both DOE and VASE confirmed that fibrinogen forms a thicker and more packed surface adlayer compared to a more porous and weakly adsorbed albumin adlayer. A linear relation of the permittivity ([epsilon]) and dielectric loss ([epsilon]') was found for some of the dry titanium-doped hydrocarbon (TDHC) surfaces with excellent HPF adsorption ability. We discuss some aspects of TDHC's aging and its possible effects on fibrinogen adsorption. [c] 2010 Optical Society of America OCIS codes: 050.1970, 240.2130, 240.5770, 170.3890, 170.1850.
- Published
- 2010