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OBJECTIVE This study aims to compare the effects of a soy-based dietary supplement, low-dose hormone therapy (HT), and placebo on the urogenital system in postmenopausal women. METHODS In this double-blind, randomized, placebo-controlled trial, 60 healthy postmenopausal women aged 40 to 60 years (mean time since menopause, 4.1 y) were randomized into three groups: a soy dietary supplement group (90 mg of isoflavone), a low-dose HT group (1 mg of estradiol plus 0.5 mg of norethisterone), and a placebo group. Urinary, vaginal, and sexual complaints were evaluated using the urogenital subscale of the Menopause Rating Scale. Vaginal maturation value was calculated. Transvaginal sonography was performed to evaluate endometrial thickness. Genital bleeding pattern was assessed. Statistical analysis was performed using χ(2) test, Fisher's exact test, paired Student's t test, Kruskal-Wallis test, Kruskal-Wallis nonparametric test, and analysis of variance. For intergroup comparisons, Kruskal-Wallis nonparametric test (followed by Mann-Whitney U test) was used. RESULTS Vaginal dryness improved significantly in the soy and HT groups (P = 0.04). Urinary and sexual symptoms did not change with treatment in the three groups. After 16 weeks of treatment, there was a significant increase in maturation value only in the HT group (P < 0.01). Vaginal pH decreased only in this group (P < 0.01). There were no statistically significant differences in endometrial thickness between the three groups, and the adverse effects evaluated were similar. CONCLUSIONS This study shows that a soy-based dietary supplement used for 16 weeks fails to exert estrogenic action on the urogenital tract but improves vaginal dryness.

OBJECTIVE This study aims to evaluate the prevalence of disability and associated factors in Brazilian women older than 50 years. METHODS We conducted a cross-sectional study (in the form of a population survey) of 622 women older than 50 years and residing in Campinas, Brazil. Disability was assessed through a questionnaire with seven items and defined as "being completely unable to perform any of them." Independent variables included self-perception of health, sociodemographic data, health-related habits, and morbidities. Statistical analysis was carried out by χ(2) test and Poisson regression. RESULTS The mean age of women was 64.1 years, and the prevalence of disability was 43.4%. Age (prevalence ratio [PR], 1.02; 95% CI, 1.01-1.03), fear of falling (PR, 1.59; 95% CI, 1.17-2.16), higher body mass index (PR, 1.03; 95% CI, 1.01-1.05), personal history of myocardial infarction (PR, 1.36; 95% CI, 1.06-1.76), smoking more than 15 cigarettes per day (PR, 1.34; 95% CI, 1.04-1.72), hospitalization in the past year (PR, 1.29; 95% CI, 1.03-1.62), multimorbidity (PR, 1.43; 95% CI, 1.02-2.02), and use of any medication prescribed by a doctor (PR, 1.57; 95% CI, 1.02-2.41) were associated with a higher prevalence of disability. Self-perception of health as good/very good (PR, 0.67; 95% CI, 0.52-0.86), use of alternative medications (PR, 0.54; 95% CI, 0.33-0.90), and more years of schooling (PR, 0.65; 95% CI, 0.45-0.93) were associated with a lower prevalence of disability. CONCLUSIONS The results improve our understanding of the factors associated with disability in Brazilian women and may help identify those who need multidisciplinary support to reduce effects on quality of life.

OBJECTIVE The aim of this study was to evaluate factors associated with self-perception of health among women 50 years or older living in a Brazilian city. METHODS A cross-sectional, population-based study was conducted using self-reported data from a household survey carried out in a sample of 622 women 50 years or older. Sociodemographic and clinical factors associated with the women's perception of their own health (very good, good, fair, poor, or very poor) were assessed. χ2 test and Poison multiple logistic regression analysis were used to select the principal factors associated with a poorer perception of health at a significance level of 5%. RESULTS Multiple analyses showed that the probability of association of chronic diseases with a woman's perception of her health as fair, poor, or very poor increased by 97% when at least two morbidities were present, whereas for each point (kg/m2) increase in body mass index, the probability of association with her perceiving her health as poorer increased by 2% (95% CI, 1.01-1.04). The probability of association decreased by 50% if she had more than 8 years of schooling (95% CI, 0.36-0.70), by 29% if she had health insurance (95% CI, 0.59-0.86), and by 32% if she performed physical exercise weekly (95% CI, 0.54-0.86). CONCLUSIONS The presence of multimorbidities and a higher body mass index increases the probability of association with a woman's poorer perception of her own health, whereas having more than 8 years of schooling, having medical insurance, and performing physical exercise weekly decreases the probability of association with a poorer perception of health.

Objective The aim of this study was to evaluate the presence of multimorbidity and associated factors in Brazilian women aged 40 to 65 years with 11 or more years of school education. Methods A secondary analysis of a cross-sectional population-based study was conducted using an anonymous self-report questionnaire completed by 377 women. The number of reported morbid conditions was evaluated (depression, hypertension, diabetes mellitus, urinary incontinence, and insomnia) and classified as none or one and two or more morbid conditions. The sociodemographic, behavioral, clinical, and reproductive factors associated with these conditions were also assessed. The χ test and multiple logistic regression analysis with stepwise selection criteria were used to select the major factors associated with morbid conditions, with a significance level set at 5%. Results Insomnia was reported by 38.5%, depression by 31%, hypertension by 28.4%, urinary incontinence by 23.2%, and diabetes by 6.3% of the participants. In this sample, 28.9% did not report any morbid conditions, 31.8% reported one morbid condition, and 39.3% reported two or more morbid conditions. On logistic regression analysis, the increased likelihood of having two or more morbid conditions was associated with bad/fair self-perception of health (increased 5.1 times; 95% CI, 1.85-14.1), nonperformance of physical activity (increased by 2.7 times; 95% CI, 1.08-6.81), obesity (increased by 30.3 times; 95% CI, 3.17-250), postmenopause (increased by 4.4 times; 95% CI, 1.57-12.11), and nervousness (increased by 3.8 times; 95% CI, 1.45-9.8). Conclusions A worse self-perception of health, sedentariness, obesity, nervousness, and being postmenopausal were associated with multimorbidity.

Objective The aim of this study was to evaluate the prevalence of endometrial premalignant and malignant polyps in premenopausal and postmenopausal women, as well as the clinical, ultrasound, and hysteroscopic factors associated with malignancy. Methods All women undergoing hysteroscopic resection of endometrial polyps from January 1998 to December 2008 were selected using a computerized database from the operating theater of the Prof. Dr. Jose Aristodemo Pinotti Women's Hospital, Women's Health Care Center/University of Campinas. Eight hundred seventy women with ages ranging from 25 to 85 years were included. Polyps were classified into benign (endometrial polyps and polyps with nonatypical simple hyperplasia and nonatypical complex hyperplasia), premalignant (polyps with atypical simple hyperplasia or atypical complex hyperplasia), and malignant. Statistical analysis was performed by measurement of the frequencies, means, and SD. The risk factors for malignancy were assessed by bivariate and multiple regression analyses, using the Epi-Info 2000 program and SAS (Statistical Analysis Software), version 9.2. Results The mean (SD) age of the women was 57.5 (10.6) years. Of these women, 76.4% were postmenopausal. Women were diagnosed with benign lesions in 95.8% of cases. Premalignant polyps accounted for 1.6% of the total number of cases. Malignant polyps represented 2.5% of the total sample. Postmenopausal bleeding and age greater than 60 years were the only factors that remained associated with a higher risk of malignancy with a prevalence ratio of 3.67 (95% CI, 1.69-7.97) and 1.5 (95% CI, 1.01-1.09), respectively. Conclusions The prevalence rate of malignancy in endometrial polyps was higher in women with postmenopausal bleeding and advanced age.

To evaluate the factors associated with the sexuality of middle-aged women with sexual partners.A cross-sectional, population-based study was carried out using an anonymous, self-response questionnaire completed by Brazilian-born women 40 to 65 years old with 11 years or more of formal education who had a sexual partner. Of the 378 women who agreed to participate in the study, 219 answered all the questions used for calculation of the sexuality score and reported having a sexual partner. The instrument was based on the Short Personal Experiences Questionnaire. Seven components were analyzed: satisfaction in sexual activities, orgasm, intensity of desire, self-classification of sexual life, and frequency of arousal, sexual activity, and sexual fantasies. Sociodemographic, clinical, behavioral, reproductive, and partner-related factors were evaluated. Poisson multiple regression analysis was performed, and prevalence ratios (PRs) with their 95% CIs were estimated.The median sexuality score was 9 (range, 2.45-13.77). The prevalence of below-median scores was higher in women who lived with their sexual partner (PR = 2.07; 95% CI: 1.17-3.69), who were in the menopausal transition or were postmenopausal (PR = 1.69; 95% CI: 1.08-2.65), and who were hypertensive (PR = 1.65; 95% CI: 1.19-2.30). Sexual activities involving penetration (PR = 0.48; 95% CI: 0.31-0.73) and a score of 6 for satisfaction with partner as a lover (PR = 0.34; 95% CI: 0.20-0.60) were indicative of a protective effect against poor sexuality.In this cohort, the sexuality of women in midlife was negatively associated with the factors of living with a sexual partner, being in the menopausal transition or postmenopausal, and being hypertensive. Therefore, greater attention should be paid to identifying these factors, and measures should be adopted to minimize their repercussions on the sexuality of middle-aged women.