1. Abstract 294: Heavy Alcohol Use Worsens Peripheral Artery Disease-Associated Myopathy
- Author
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Panagiotis Koutakis, Ahmed Ismaeel, Emma Fletcher, Evlampia Papoutsi, Robert Smith, William Bohannon, and Dimitrios Miserlis
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Heavy alcohol use can induce skeletal muscle dysfunction referred to as alcoholic myopathy. Likewise, peripheral artery disease (PAD) is characterized by an acquired skeletal muscle metabolic myopathy in ischemic muscles of the lower extremity. Although epidemiological studies have shown that heavy alcohol consumption is associated with a greater risk of PAD, data are lacking on the contribution of alcohol-related myopathy on PAD-associated skeletal muscle pathology. We compared myofiber morphometrics, mitochondrial respiration, and oxidative stress measures in gastrocnemius biopsies from PAD patients with heavy alcohol use (>7 or >14 drinks per week, for females and males, respectively) (n=13) to PAD patients (n=13) and non-PAD controls (n=17) consuming moderate to low/no alcohol. Myofiber area and diameter were lower in heavy-drinking PAD patients compared to low/moderate drinkers (p=0.03 and p=0.04, respectively) and non-PAD controls (p=0.02 and p
- Published
- 2022
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