1. Superficial Acral Fibromyxoma of the Toe: Unusual Location of the Mixoid Variant
- Author
-
Pietro Rubegni, Clelia Miracco, Michele Fimiani, and Arianna Lamberti
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Biopsy ,CD99 ,CD34 ,Soft Tissue Neoplasms ,Fibroma ,Dermatology ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Stroma ,differential diagnosis ,myxoid variant ,Biomarkers, Tumor ,medicine ,Humans ,superficial acral fibromyxoma ,medicine.diagnostic_test ,business.industry ,Superficial acral fibromyxoma ,Soft tissue ,General Medicine ,Anatomy ,Middle Aged ,Toes ,medicine.disease ,Immunohistochemistry ,immunohistochemistry ,Treatment Outcome ,Solitary mass ,030220 oncology & carcinogenesis ,business - Abstract
Superficial acral fibromyxoma (SAFM) is a rare soft tissue tumor that frequently involves the periungual and subungual regions of acral surfaces. Macroscopically, it appears as a flesh-colored dome-shaped solitary mass; microscopically, it consists of a moderately cellular proliferation of spindle-shaped fibroblast-like cells embedded in a myxocollagenous stroma and arranged in a loose storiform and focally fascicular pattern. The tumor cells are immunoreactive for CD34, epithelial membrane antigen, CD99, and CD10. In this study, we describe a case of SAFM on the fourth toe with predominantly myxoid stroma. Our case, in contrast of those reported in the literature, showed an unusual location for the myxoid variant. SAFM is often not recognized; it may resemble some benign and malignant mesenchymal neoplasm. The gold standard treatment is surgery. The tumor was completely excised, and no recurrence was evident at 1-year follow-up. Awareness of this entity facilitates its diagnosis and management, avoiding unwarranted concerns and additional procedures for the patient.
- Published
- 2017