1. Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults
- Author
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Mitzi M. Gonzales, Martha Pyron, Hirofumi Tanaka, Bennett A. Fallow, Andreana P. Haley, Takashi Tarumi, and Nantinee Nualnim
- Subjects
Male ,medicine.medical_specialty ,Physiology ,Physical exercise ,Neuropsychological Tests ,Vascular Stiffness ,Physical medicine and rehabilitation ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Cognitive decline ,Cerebral perfusion pressure ,Pulse wave velocity ,business.industry ,VO2 max ,Middle Aged ,medicine.disease ,Blood pressure ,Cerebral blood flow ,Physical Endurance ,Arterial stiffness ,Cardiology ,Female ,Sedentary Behavior ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Midlife vascular disease risk is a strong risk factor for late-life dementia. Central arterial stiffness, a hallmark of vascular aging, is associated with accelerated brain aging and cognitive decline. Habitual aerobic exercise is an effective lifestyle strategy to reduce central arterial stiffness and is related to lower risk of cognitive impairment. OBJECTIVE To determine the associations among cardiopulmonary fitness, neuropsychological function, central arterial stiffness, and cerebral perfusion in the sedentary and endurance-trained middle-aged adults. METHODS Twenty-six sedentary and 32 endurance-trained middle-aged adults were measured for maximal oxygen consumption, central arterial stiffness determined by aortic pulse wave velocity and carotid ultrasound, neuropsychological function, and regional cerebral blood flow assessed by MRI. RESULTS There were no group differences in age, sex, ethnicity, education, blood pressure, and carotid intima-media wall thickness (all P>0.05). Neuropsychological performance and occipitoparietal perfusion were greater, and central arterial stiffness was lower in endurance-trained individuals than in sedentary individuals (all P
- Published
- 2013
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