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Bisphenol A (BPA) is a chemical used in plastic bottles and inner coating of beverage cans, and its exposure is almost ubiquitous. BPA has been associated with hypertension and decreased heart rate variability in the previous studies. The aim of the present study was to determine whether increased BPA exposure from consumption of canned beverage actually affects blood pressure and heart rate variability. We conducted a randomized crossover trial with noninstitutionalized adults, who were aged ≥60 years and recruited from a local community center. A total of 60 participants visited the study site 3 times, and they were provided the same beverage in 2 glass bottles, 2 cans, or 1 can and 1 glass bottle at a time. The sequence of the beverage was randomized. We then measured urinary BPA concentration, blood pressure, and heart rate variability 2 hours after the consumption of each beverage. The paired t test and mixed model were used to compare the differences. The urinary BPA concentration increased after consuming canned beverages by >1600% compared with that after consuming glass bottled beverages. Systolic blood pressure adjusted for daily variance increased by ≈4.5 mm Hg after consuming 2 canned beverages compared with that after consuming 2 glass bottled beverages, and the difference was statistically significant. The parameters of the heart rate variability did not show statistically significant differences.The present study demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely.

IntroductionConcern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a hormone-disrupting chemical used in plastic and epoxy resin industries. Geraniol (a plant-derived terpene) has cytoprotective and antioxidant potential. This work aimed to study the effect of

Bisphenol A (BPA) is a high volume chemical used in a wide variety of products, including plastic bottles and canned goods. Based on widespread human exposure and endocrine effects observed first in animal studies and now in humans, this chemical is being extensively studied. Most physicians have not had formal teaching regarding human risks from environmental exposures such as BPA. This article aims to provide: 1) a basis for learning about BPA as an environmental exposure and 2) practical advice for healthcare providers to share with concerned families.Human exposure to BPA is nearly universal. Animal studies have documented a variety of endocrine effects of this chemical and recent studies involving humans are resulting in growing concerns. These studies suggest that increased exposure to BPA is correlated with diseases such as heart disease and type 2 diabetes. Based on the metabolism of BPA and its endocrine effects, scientists hypothesize that the impact on children will be magnified. Further studies are needed to clarify this issue; funding has increased dramatically in recent years and scientists are hopeful that many of the currently unanswered questions will be addressed.The evidence for harmful health effects on humans from BPA exposure is incomplete, but is sufficient to suggest that limiting exposure is warranted. Further studies involving pregnant women and young children are needed to clarify the endocrine effects of BPA on this vulnerable population.