1. Characterization of Thyroid Nodules by 4-Dimensional Computed Tomography
- Author
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Ryan David, Manoj Kumar, Donald L. Bodenner, Rohan Samant, Rudy Van Hemert, Edgardo J. Angtuaco, Ryan T. Fitzgerald, Manohar Kuruva, and Brendan C. Stack
- Subjects
Adenoma ,Adult ,Male ,Thyroid nodules ,medicine.medical_specialty ,Thyroid Gland ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Precontrast ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Thyroid Neoplasms ,Thyroid Nodule ,Four-Dimensional Computed Tomography ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Thyroid ,Reproducibility of Results ,Nodule (medicine) ,Middle Aged ,Hyperparathyroidism, Primary ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Radiology ,medicine.symptom ,business ,Primary hyperparathyroidism ,4-Dimensional Computed Tomography - Abstract
OBJECTIVE We aimed to evaluate the use of 4-dimensional computed tomography (4DCT) for characterization of thyroid nodules. METHODS Our study drew from 100 consecutive patients with primary hyperparathyroidism who underwent 4D parathyroid CT imaging for adenoma localization. Included subjects had tissue sampling of a thyroid nodule within 3 months of 4DCT. RESULTS Twenty subjects (18 women and 2 men) had thyroid nodules that were pathologically confirmed. Precontrast nodule attenuation was significantly lower in malignant nodules when compared with benign nodules (36 vs 61 HU, P = 0.05). Arterial phase and delayed phase nodule attenuations were not significantly different in malignant and benign nodules (128 vs 144 HU, P = 0.7; 74 vs 98 HU, P = 0.3). CONCLUSIONS Our initial experience with a small group of patients was unable to support the use of 4DCT for characterizing thyroid nodules; however, precontrast nodule attenuation was significantly lower in malignant nodules when compared with benign nodules.
- Published
- 2017