1. How molecular allergology can shape the management of allergic airways diseases
- Author
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Davide Caimmi, Pascal Demoly, Enrica Manca, Elena Carboni, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Foggia - University of Foggia, and Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG)
- Subjects
Allergen immunotherapy ,Allergy ,MESH: Allergens ,MESH: Asthma ,Immunology ,MESH: Molecular Diagnostic Techniques ,Disease ,Cross Reactions ,Immunologic Tests ,Immunoglobulin E ,medicine.disease_cause ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,MESH: Cross Reactions ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,MESH: Desensitization, Immunologic ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Sensitization ,MESH: Treatment Outcome ,Asthma ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,MESH: Humans ,biology ,business.industry ,MESH: Immunoglobulin E ,Allergens ,medicine.disease ,Rhinitis, Allergic ,3. Good health ,Treatment Outcome ,medicine.anatomical_structure ,Molecular Diagnostic Techniques ,030228 respiratory system ,Desensitization, Immunologic ,MESH: Immunologic Tests ,MESH: Rhinitis, Allergic ,biology.protein ,Personalized medicine ,business - Abstract
International audience; In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases.Recent findings: Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect both results from specific IgE toward allergen extracts and toward molecular allergens, to collect the most complete information on the patient's profile, and therefore to highlight genuine sensitization, and exclude cross-reaction and sensitization because of pan-allergens. Being able to know the exact molecular sensitization profile of the patient, also helps predicting the possible evolution of the disease, and targeting the most appropriate allergen immunotherapy treatment to prescribe.Summary: Even though a cost-effective analysis of running multiple assays in allergic patients has not been performed yet, such technique proved to be more efficient in detecting the appropriate treatment in each patient and in analyzing the true sensitization profile in patients suffering from allergic rhinitis, conjunctivitis, and asthma.
- Published
- 2020