1. Abstract 104: The Use of Nitrated apolipoprotein A1 (NT-ApoA1) to Predict Mortality in Patients with Known or Suspected Coronary Artery Disease
- Author
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Abid Ullah, Jonathan D. Marmur, Kiran Javaid, Mohammed Al-Sadawi, Haroon Kamran, Alexander Parpas, Erdal Cavusoglu, Sriya Avadhani, Lena Woo, and Samantha Cavusoglu
- Subjects
medicine.medical_specialty ,biology ,business.industry ,medicine.disease ,Coronary artery disease ,Internal medicine ,medicine ,biology.protein ,Cardiology ,lipids (amino acids, peptides, and proteins) ,Apolipoprotein A1 ,In patient ,Cardiology and Cardiovascular Medicine ,business ,Cardiovascular mortality - Abstract
Background: Studies have suggested that nitrated apolipoprotein A1 (NT-apoA1) levels may be associated with coronary artery disease (CAD). We therefore hypothesized that NT-apoA1 might be associated with the prediction of all-cause mortality in CAD patients. Methods: Using an ELISA, we measured plasma NT-apoA1 levels in 236 patients with known or suspected coronary artery disease (CAD) undergoing coronary angiography. The patients were then followed prospectively for the development of all-cause mortality for up to 7 years. Results: Lower NT-apoA1 levels were associated with worse renal function, lower HDL levels, higher triglyceride levels and lower ejection fraction. There was positive correlation between NT-apoA1 and HDL cholesterol levels (correlation coefficient 0.366; p Conclusions: Higher NT-apoA1 levels are significantly associated with lower all-cause mortality in CAD patients, which may relate to HDL cholesterol function. Further studies are warranted to investigate this paradoxical finding.
- Published
- 2019
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