1. Preeclampsia and Fetal Loss in Women With a History of Venous Thromboembolism
- Author
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Helga Grafenhofer, Ingrid Pabinger, Adriana Ilic, Klaus Lechner, Christine Mannhalter, Alexandra Kaider, Peter Quehenberger, Peter Husslein, and S. Eichinger
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Birth weight ,Miscarriage ,Preeclampsia ,Pre-Eclampsia ,Pregnancy ,Risk Factors ,Thromboembolism ,Prevalence ,medicine ,Birth Weight ,Humans ,Fetal Death ,Retrospective Studies ,Venous Thrombosis ,business.industry ,Obstetrics ,Odds ratio ,Middle Aged ,medicine.disease ,Venous thrombosis ,Hypertension ,Gestation ,Female ,Cardiology and Cardiovascular Medicine ,business ,Body mass index - Abstract
Abstract —A higher prevalence of risk factors for venous thromboembolism (VTE) has been found in women with preeclampsia and fetal loss. We investigated whether women with a history of VTE have a higher prevalence of pregnancy-associated complications compared with control subjects. In 395 patients with a history of VTE and in 313 control women, the prevalence of complications during pregnancy and the mean birth weight of viable infants were evaluated. The prevalence of pregnancy-induced hypertension and preeclampsia was higher in patients (5.1% and 3.0%, respectively) compared with control subjects (1.3% each). The odds ratio was 4.13 for pregnancy-induced hypertension (95% CI 1.4 to 12.22, P =0.0058) and 2.43 for preeclampsia (95% CI 0.78 to 7.6, P =0.133). Stillbirth was slightly more frequent in patients (4.3%) than in control subjects (3.2%); the difference was not statistically significant. Miscarriage was equally frequent in patients (21.8%) and control subjects (21.3%). The birth weight of viable infants born to patients was, on average, 109 g lower than that of the infants born to the control subjects ( P =0.014) after adjustment for the mother’s body mass index. Our study demonstrates that women with a predisposition to VTE have, overall, a good chance for a successful pregnancy outcome. However, the findings from our study support the assumption that a predisposition to venous thrombosis is associated with a higher risk for complications during pregnancy and lower infant birth weight.
- Published
- 2001
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