289 results on '"Melman A"'
Search Results
2. HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy
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Mauricio Lisker‐Melman, Abdus S. Wahed, Marc G. Ghany, Raymond T. Chung, Wendy C. King, David E. Kleiner, Atul K. Bhan, Mandana Khalili, Mamta K. Jain, Mark Sulkowski, David K. Wong, Gavin Cloherty, and Richard K. Sterling more...
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Hepatology - Abstract
Liver injury may persist in patients with HBV receiving antiviral therapy who have ongoing transcription and translation. We sought to assess ongoing HBV transcription by serum HBV RNA, translation by serum hepatitis B core related antigen (HBcrAg), and their associations with hepatic HBsAg and HBcAg staining in patients coinfected with HBV and HIV.This is a cross-sectional study of 110 adults coinfected with HBV and HIV who underwent clinical assessment and liver biopsy. Immunohistochemistry (IHC) was performed for HBsAg and HBcAg. Viral biomarkers included quantitative HBsAg, HBV RNA, and HBcrAg.Participants' median age was 49 years (male, 93%; Black, 51%; HBeAg+, 65%), with suppressed HBV DNA (79%) and undetectable HIV RNA (77%) on dually active antiretroviral therapy. Overall, HBV RNA and HBcrAg were quantifiable in 81% and 83%, respectively (96% and 100% in HBeAg+, respectively). HBcAg staining was detected in 60% and HBsAg in 79%. Higher HBV RNA was associated with higher HBcAg and HBsAg IHC grades (both p 0.0001). The HBsAg membranous staining pattern was significantly associated with higher HBV-RNA and HBcrAg levels.HBcAg and HBsAg IHC staining persisted despite viral suppression, and IHC grades and staining patterns correlated with markers of transcription (HBV RNA) and translation (HBcrAg). These data indicate that apparent HBV suppression is associated with residual transcription and translation that could contribute to liver pathology. Additional antiviral strategies directed to HBV protein expression may be useful to ameliorate liver injury. more...
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- 2022
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3. Use of HBV RNA and to predict change in serological status and disease activity in CHB
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Ghany, Marc G., primary, King, Wendy C., additional, Hinerman, Amanda S., additional, Lok, Anna SF., additional, Lisker-Melman, Mauricio, additional, Chung, Raymond T., additional, Terrault, Norah, additional, Janssen, Harry L.A., additional, Khalili, Mandana, additional, Lee, William M., additional, Lau, Daryl T.Y., additional, Cloherty, Gavin A., additional, and Sterling, Richard K., additional more...
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- 2023
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4. Use of HBV RNA and hepatitis B core-related antigen to predict change in serological status and disease activity in CHB
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Marc G. Ghany, Wendy C. King, Amanda S. Hinerman, Anna SF. Lok, Mauricio Lisker-Melman, Raymond T. Chung, Norah Terrault, Harry L.A. Janssen, Mandana Khalili, William M. Lee, Daryl T.Y. Lau, Gavin A. Cloherty, and Richard K. Sterling more...
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Hepatology - Published
- 2023
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5. Changes in serum hepatitis B surface and e antigen, interferon‐inducible protein 10, and aminotransferase levels during combination therapy of immune‐tolerant chronic hepatitis B
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Robert, Perrillo, Hsing-Hua S, Lin, Kathleen B, Schwarz, Philip, Rosenthal, Mauricio, Lisker-Melman, Raymond T, Chung, Ludmila, Prokunina-Olsson, Gavin, Cloherty, Jordan, Feld, and David, Kleiner
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Adult ,Hepatitis B virus ,Hepatitis B Surface Antigens ,Hepatology ,Alanine Transaminase ,Antiviral Agents ,Chemokine CXCL10 ,Hepatitis B, Chronic ,Treatment Outcome ,DNA, Viral ,Humans ,RNA ,Hepatitis B e Antigens ,Child - Abstract
Treatment of immune-tolerant (IT) children and adults with combined peginterferon alfa-2a and entecavir results in a decline in serum HBeAg and HBsAg concentrations but rarely results in loss of HBeAg or sustained off-treatment response. Factors associated with declines in these viral antigens during treatment remain unexplored.We investigated the pattern of virologic and biochemical response in 86 participants (59 children, 27 adults) by serial quantitative measurement of HBsAg (qHBsAg), quantitative HBeAg (qHBeAg), HBV RNA, interferon-inducible protein (IP-10), IL-18, and alanine aminotransferase (ALT). Each individual had previously been treated with 8 weeks of entecavir followed by 40 weeks of combined peginteferon and entecavir. We defined the interrelationships between these parameters and virologic response measured as nadir declines from baseline for HBeAg and HBsAg. The patterns of HBsAg and HBeAg decline were similar in pediatric and adult participants. Higher levels of IP-10 were observed during treatment in participants with greater ALT elevations and greater reductions of qHBsAg and qHBeAg. Individuals with peak ALT values exceeding three times the upper limit of normal were significantly more likely to have1 logInduction of IP-10 during peginterferon treatment in adults and children in the IT phase of chronic HBV infection is associated with ALT elevations and decline in viral antigens, suggesting a degree of interferon-inducible viral control. more...
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- 2022
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6. Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B
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Norah A, Terrault, Anna S, Lok, Abdus S, Wahed, Marc G, Ghany, Robert P, Perrillo, Michael W, Fried, David K, Wong, Mandana, Khalili, Daryl T Y, Lau, Richard K, Sterling, Adrian M, Di Bisceglie, Mauricio, Lisker-Melman, Stewart L, Cooper, Ray T, Chung, Keyur, Patel, Lewis R, Roberts, Steven H, Belle, and Harry L A, Janssen more...
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Hepatology ,Gastroenterology - Abstract
Hepatitis B surface antigen (HBsAg) loss is associated with improved long-term outcomes of patients with chronic hepatitis B but is infrequently achieved with current monotherapies. We assessed whether combination strategies that included treatment withdrawal enhanced HBsAg loss.A randomized (1:1) trial of tenofovir disoproxil fumarate (TDF) for 192 weeks with or without peginterferon (PegIFN) alfa-2a for the first 24 weeks, followed by withdrawal of TDF at week 192 with 48 weeks of off-treatment follow-up to week 240. The primary end point was HBsAg loss at week 240.Of 201 participants (52% HBeAg positive, 12%/6% genotype A/A2, 7% cirrhosis) randomized to TDF + PegIFN (n = 102) or TDF alone (n = 99), 6 participants had lost HBsAg at the end of the treatment phase (week 192), 5 (5.3%) in the combination group, and 1 (1.0%) in the TDF alone group (P = 0.09). By week 240, 9 participants had cleared HBsAg, 5.3% in combination, and 4.1% in monotherapy arms (P = 0.73). HBsAg decline and loss occurred earlier with TDF + PegIFN than TDF, with a ≥1-logIU/mL qHBsAg decline by week 24 in 28% in TDF + PegIFN compared with 6% in TDF (P = 0.04). HBsAg loss occurred in 7 of 12 (58%) with hepatitis B virus subgenotype A2 (all HBeAg positive) compared with only 2 of 189 (1%) with other hepatitis B virus genotypes and in 8 of 93 (8.6%) HBeAg positive vs 1 of 87 (1.1%) HBeAg negative.PegIFN combined TDF followed by protocolized TDF withdrawal led to earlier but not higher percentages of HBsAg clearance. Pretreatment HBeAg positivity and subgenotype A2 were strongly associated with HBsAg clearance. more...
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- 2022
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7. Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B
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Terrault, Norah A., primary, Lok, Anna S., additional, Wahed, Abdus S., additional, Ghany, Marc G., additional, Perrillo, Robert P., additional, Fried, Michael W., additional, Wong, David K., additional, Khalili, Mandana, additional, Lau, Daryl T.Y., additional, Sterling, Richard K., additional, Di Bisceglie, Adrian M., additional, Lisker-Melman, M., additional, Cooper, Stewart L., additional, Chung, Ray T., additional, Patel, Keyur, additional, Roberts, Lewis R., additional, Belle, Steven H., additional, and Janssen, Harry L.A., additional more...
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- 2022
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8. Hepatic Steatosis and Steatohepatitis in a Large North American Cohort of Adults With Chronic Hepatitis B
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Anna S. Lok, Mauricio Lisker-Melman, Wendy C. King, Marc G. Ghany, Philip J. Rosenthal, David E. Kleiner, Atul K. Bhan, Raymond T. Chung, Mandana Khalili, Rageshree Ramachandran, and Richard K. Sterling more...
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Adult ,Male ,medicine.medical_specialty ,Cirrhosis ,Adolescent ,Biopsy ,Gastroenterology ,Article ,Liver disease ,Hepatitis B, Chronic ,Risk Factors ,Fibrosis ,Internal medicine ,Humans ,Medicine ,Aged ,Hepatology ,business.industry ,Fatty liver ,Age Factors ,Middle Aged ,Hepatitis B ,medicine.disease ,Fatty Liver ,North America ,Disease Progression ,Female ,Steatohepatitis ,Steatosis ,business ,Liver cancer - Abstract
INTRODUCTION Fatty liver disease (FLD) influences liver disease progression and liver cancer risk. We investigated the impact of FLD on liver disease severity in a large North American cohort with chronic hepatitis B virus (HBV). METHODS Liver biopsies from 420 hepatitis B surface antigen-positive adults enrolled in the Hepatitis B Research Network and who were not on HBV therapy in the previous month were evaluated for inflammation and fibrosis. Steatohepatitis was based on steatosis, hepatocyte ballooning ± Mallory-Denk bodies, and perisinusoidal fibrosis. Models evaluated factors associated with steatohepatitis, and the associations of steatohepatitis with fibrosis, and longitudinal alanine aminotransferase, aspartate aminotransferase, and Fibrosis-4. RESULTS The median age was 42 years, 62.5% were male, and 79.5% were Asian. One hundred thirty-two (31.4%) patients had FLD (77 [18.3%] steatosis only, 55 [13.1%] steatohepatitis). Older age, overweight/obesity, and diabetes were associated with steatohepatitis. Steatohepatitis (vs no FLD) was associated with 1.68 times higher risk of advanced fibrosis at baseline (95% confidence interval, 1.12-2.51), and there was an indication of higher incident cirrhosis rate during follow-up. Steatohepatitis vs no FLD was also independently associated with, on average, 1.39 times higher alanine aminotransferase (P < 0.01) and 1.25 times higher Fibrosis-4 (P = 0.04) across 4 years. DISCUSSION Coexisting steatosis occurred in nearly a third of adults (13% had steatohepatitis) with chronic HBV in this North American cohort who underwent liver biopsies. Steatohepatitis was associated with advanced fibrosis and higher biochemical measures of hepatic inflammation over time. Therefore, in addition to viral suppression, screening for and managing metabolic abnormalities is important to prevent disease progression in HBV. more...
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- 2021
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9. HBV transcription and translation persist despite viral suppression in HBV‐HIV co‐infected patients on antiretroviral therapy
- Author
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Lisker‐Melman, Mauricio, primary, Wahed, Abdus S., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, King, Wendy C., additional, Kleiner, David E., additional, Bhan, Atul K., additional, Khalili, Mandana, additional, Jain, Mamta K., additional, Sulkowski, Mark, additional, Wong, David K., additional, Cloherty, Gavin, additional, and Sterling, Richard K., additional more...
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- 2022
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10. Reply to Li, Henry, and Nguyen
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Khalili, Mandana, primary, Kleiner, David E., additional, King, Wendy C., additional, Sterling, Richard K., additional, Ghany, Marc G., additional, Chung, Raymond T., additional, Bhan, Atul K., additional, Rosenthal, Philip, additional, Lisker-Melman, Mauricio, additional, Ramachandran, Rageshree, additional, and Lok, Anna S., additional more...
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- 2022
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11. Incidence and prediction of HBsAg seroclearance in a prospective multi‐ethnic HBeAg ‐negative chronic hepatitis B cohort
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Terrault, Norah A., primary, Wahed, Abdus S., additional, Feld, Jordan J., additional, Cooper, Stewart L., additional, Ghany, Mark G., additional, Lisker‐Melman, Mauricio, additional, Perrillo, Robert, additional, Sterling, Richard K., additional, Khalili, Mandana, additional, Chung, Raymond T., additional, Rosenthal, Philip, additional, Fontana, Robert J., additional, Sarowar, Arif, additional, Lau, Daryl T. Y., additional, Wang, Junyao, additional, Lok, Anna S., additional, and Janssen, Harry L. A., additional more...
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- 2022
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12. Reply
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Ghany, Marc G., primary, King, Wendy C., additional, Lisker‐Melman, Mauricio, additional, Lok, Anna S. F., additional, Terrault, Norah, additional, Janssen, Harry L. A., additional, Khalili, Mandana, additional, Chung, Raymond T., additional, Lee, William M., additional, Lau, Daryl T. Y., additional, Cloherty, Gavin A., additional, and Sterling, Richard K., additional more...
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- 2021
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13. Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation
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Voelkel-Babyesiza, R., Chen, D. D., Jaufeerally, F. R., Lee, Y. M., Lim, G., Lim, W. T., Thng, S., Yap, S. Y., Yeo, C., Oh, S., Pak, H. N., Kim, J-B, Kim, J. H., Jang, S-W, Kim, D. H., Ryu, D. R., Park, S. W., Kim, D-K, Choi, D. J., Oh, Y. S., Cho, M-C, Kim, S-H, Jeon, H-K, Shin, D-G, Park, J. S., Park, H. K., Han, S-J, Sung, J. H., Nam, G-B, On, Y. K., Lim, H. E., Kwak, J. J., Cha, T-J, Hong, T. J., Park, S. H., Yoon, J. H., Kim, N-H, Kim, K-S, Jung, B. C., Hwang, G-S, Kim, C-J, Worthy, V, Verdi, C., Tripti, T., Treasure, L., Thompson, N., Theobald, H., Thatcher, A., Stephanie, B., Smith, K., Shoemaker, J., Shaw, P., Sanghera, T., Sage, A., Robertson, C., Richardson, T., Richard, C., Raziano, S., Raynor, J., Purcell, T., Pickelsimer, N., Peterson, J., Pearl, G., Paserchia, S., Parrott, T., Parker, M., Palumbo, V, Orosco, C., Mooso, B., Minardo, J., Merritt, D., Malone, E., Lincoln, T., Lee, J. A., Lay, M., Langdon, J., Knowles, P., Kerr, J., Keeling, M., Karl, S., Jones, P., Jones, L., Jones, A., Jasinski, S., Hicks, T., Herrick, C., Henson, L., Headlee, M., Hawkins, B., Hartranft, E., Harbour, T., Hakimi, F., Haideri, A., Gentry, P., Fielder, D., Ferdinand, K., Felpel, S., Evans, L., Eley, M., Dickerson, A., DePauw, J., Congal, S., Cervellione, K., Cassidy, D., Canova, M., Cameron-Watts, J., Browne, A., Brown, A., Bowers, S., Bentley, M., Bartlett, M., Asafu-Adjaye, N., Treasure, C., Nishijima, D., Pitta, S., Duffy, P., Noveck, H., Ison, R., Alberts, M., Remmel, K., Theodoro, D., Diercks, D., Delafontaine, P., Ahmed, W., Reddy, R., Haque, I, Gutowski, T., Alfieri, A., Beach, S., Miller, S., Williams, M., Mendelson, R., Falkowski, S., Franco, M., Cox, M., Kutayli, W. M., Ferrick, K., Quick, A., Wilson, V, Mullen, P., Garcia, J., Blumberg, E., Rama, P., Canosa, R., Goldhaber, S. Z., Thanzeel, M., Sharma, R., Sharma, N., Mohamed, R., Maqsood, I, Makdad, M., Magdaluyo, K., Jadhav, S., Haridas, P., El Bardisy, S., Al Mulla, A., Abdul, A., Subbaraman, B., Khan, M., Gupta, R., Wassef, A., Bazargani, N., Maruthanayagam, R., Al Naeemi, A., Al Omairi, M., Abu-Mahfouz, M., Naguib, A., Singh, R., Esheiba, E. M., Ibrahim, M., Nathani, M., Agrawal, A., Yousef, G., Al Mahmeed, W., van Zyl, F., Tau, T., Tarr, G., Smith, L., Skein, A., Shaik, F., Sasto, J., Salie, M., Rikhotso, L., Page, A., Mostert, M., Mavhusa, L., Marks, J., Loyd, E., Karsten, M., Henley, L., Ellis, T., Du Plessis, G., de Meyer, L., Davids, A., Conway, G., Chami, C., Cassimjee, S., Cannon, C., Boshoff, C., Booysen, M., Bester, C., Angel, G., Oosthuysen, W., Maharajh, S., Ramdass, A., Engelbrecht, J., Ahmed, F., Ismail, S., Loghdey, R., Ueckermann, V, Mntla, P., Greyling, D., Louw, R., Murray, A., Theron, H., van Zyl, L., Guerra, M., Pillay, T., Garda, R., Kelfkens, Y., Horak, A., Siebert, H., Bayat, J., Kettles, D., Zaatout, E., Tawfik, M., Taha, N., Soliman, A., Sobhy, M., Setiha, M., Samir, S., Sami, N., Salem, H., Reda, M., Reda, A., Ohanissian, A., Nawar, M., Mowafy, A., Khairy, T., Katta, A., Elkhadem, M., El-Etreby, A., Elbahry, A., El Etriby, S., El Din, M. G., Abou Seif, S. K., Abd El-Aziz, A., Ragy, H., Wright, D., Wong, S., Trahey, T., Stevenson, J., Spearson, S., Snell, L., Schulman, S., Sas, G., Robinson, M., Roberts, P., Raines, M., Pinter, A., Petrie, F., Pandey, M., Otis, R., Otis, J., Neas, I, Navratil, J., Moor, R., Mangat, I, Lewis, S., Lewis, C., Largy, J., Kwan, L., Kornder, J., Korley, V, Kim, R., Kelly, S., Kahlon, R., Jethoo, G., Jean, C., Jackson, A. M., Hines, K., Hines, C., Haveman, K., Gulliver, W., Grenier, M-C, Fox, B., Fournier, D., Ferleyko, L., Fearon, A., Farquhar, D., Ewert, A., Dunnigan, J., Douglass, S., Dorian, P., Djaidani, Z., Denis, I, Dehghani, P., Daheb, S., Cleveland, T., Clarke, B., Carroll, L., Burke, E., Breakwell, L., Bignell, N., Bigcanoe, J., Bergeron, C., Beaudry, K., Aves, T., Aro, L., Ahmad, K., Bonet, J., Ramjattan, B., Cha, J., Lavoie, A., Parkash, R., Fikry, S., Vizel, S., MacDonald, P., Angaran, P., Coutu, B., Schweitzer, B., Hruczkowski, T., Dhillon, R., Dresser, G., Nadeau, R., Du Preez, M., Poirier, G., Heath, J., Berlingieri, J., Ayala-Paredes, F., Beaudry, P., Leader, R., Cheung, S., Pandey, A. S., Gupta, M., Luton, R., Eikelboom, J., Spyropoulos, A., Connolly, S. J., Wong, K., Wilford, E., Wallis, L., Waldman, A., Vorster, M., Tsay, I. M., Thompson, S., Tarrant, J., Swaraj, K., Sutcliffe, S., Stoyanov, N., Singleton, C., Singh, C., Shrestha, P., Shone, S., Setio, H., Seremetkoska, M., Sanders, L., Rose, J., Raynes, S., Ratcliffe, M., Rashad, H., Preston, S., Plotz, M., Paul, V, Patching, T., Patching, K., Parsons, L., Palmer, J., O'May, V, Oldfield, G., Nagalingam, V, Myers, J-D, Mussap, C., Morrison, H., McKeon, L., McIntosh, C., McCarthy, C., MacKenzie, M., Mackay, S., Leung, D., Lehman, S., Lehman, M., Lawlor, V, Kassam, I, Juergens, C., Johnson, K., Jacobson, B., Hoffmann, B., Hesketh, L., Hegde, M. P., Hayes, K., Modi, M. H., Grabek, T., Gibbs, J., Geraghty, R., Fitzpatrick, D., Fetahovic, T., Ferreira-Jardim, A., Eslick, R., Eskandari, M., Duroux, M., Dolman, M., Dixon, S., Dimitri, H., Cresp, D., Conway, B., Connelly, A., Carlton, L., Campo, M., Buckley, E., Boys, J., Bonner, M., Black, A., Beveridge, R., Batta, C., Barry, L., Aggarwala, A., Faunt, J., Carroll, P., Starmer, G., Rogers, J., Lee, A., Binnekamp, M., Jepson, N., Arstall, M., Astridge, P., Choi, A., O'Donnell, D., Crimmins, D., Blombery, P., Phan, T., Ayres, B., Zimmett, L., French, J., Eccleston, D., Kiat, H., Colquhoun, D., Catanchin, A., Coulshed, D., Kilian, J., Roberts-Thomson, P., Lehman, R., Abhayaratna, W., Van Gaal, W., Singh, B., Blenkhorn, A., Gibbs, H., Thomson, A., Thomas, N., Sword, A., Stoddart, H., Simper, H., Simmons, P., Shewring, J., Seamark, C., Saunders, P. B., Rogers, G., Rickenbach, M., Reed, R., Redpath, D., Randfield, S., Powell, K., Nadaph, M., Muvva, R., Munro, I, Lomax, L., Jeffers, L., Jacobs, P., Hay, A., Halpin, A., Goram, J., Fox, R., Flynn, A., Dooldeniya, C., Dobson, S., Cartwright, S., Bennett, J., Ayers, J., A'Court, C., Ahmad, S., Pugsley, M., Gunasegaram, J., Wong, M., Cooke, P., Beattie, A., McEleny, P., Wastling, R., McGinty, P., Bandrapalli, M., Liley, C., Vinson, P., Zaman, K., Davies, T., Forshaw, K., Veale, R., Wilkinson, J., Geatch, D., Estifano, S., Myhill, T., Lucraft, L., Batson, R., Choi, H., Stephenson, T., Hargreaves, N., Schatzberger, T., Davies, S., Baron, R. T., Haria-Shah, R., Bunney, R., Boon, M., Wong, T., Sterry, M., Shepherd, D., Walton, S., Jackson, D., Ward, B., Coates, S., Heer, A., Roberts, N., Coulson, W., Peters, S., Wilson, A., Khalaque, S., Choudhary, F., Sabir, A., Rothwell, A. C., Kim, D. B., Edwards, D., Braddick, M., Mannion, S., Aylward, M., Oliver, R., Hawkins, C., Galloway, S., Sharma, P., Heath, R., Danielsen, M., Neden, C. A., Stuart, E., Davies, R., Hart, N., Ali, A., Patel, J. R. A., Pinnock, H., Roome, P. C., Vercoe, S., Hodgins, I, Webster, J., Dau, H. S., Kamath, R., Lowe, S., Smith, R. N., Burns, G., Conn, P., Warke, A., Mulholland, C., Poland, K., McLeod, A. J., Glencross, S., Gibbons, L., Haq, I. U., Little, H., Barrow, S., Butter, K. C., Howard, M., Zaidi, S. M. A., Chigbo, C., Thompson, R., Walls, N., Hutton, C., Jacobs, M., Abushal, S., Davies, E., Oliver, J. L., Priyadharshan, R., Rogers, S., Milne, K., Parfitt, M., Wakeling, J., Alborough, E., Kelsall, A. R., Fooks, T., Fisher, E., Litchfield, J., Bisatt, J., Clark, M., Gray, D., Bird, N., Vishwanathan, B., Howitt, A., Strieder, E., Gilliland, A., de Kare-Silver, N., Sathananthan, S., Cairns, J., Willcock, W., Ahmad, N., Sarai, B., Watson, E., Thomas, M. J., Jones, K. P., Van Zon, G., Bradshaw, C., Cumberlidge, D. F., Douglas, K., Ladha, K., Saigol, M., Wong, S. W., Patel, R. P., Lumley, L., Murdoch, W., Kernick, D., Eden, J., Weeks, P., Jones, C. P., Ainsworth, P., Davies, J. A., Russell, D., Sinha, B., Railton, T., Gallagher, A., Pandya, P., Matthews, J., Wadeson, P., Thurston, S., West, R., Stipp, Y., Macey, N., Scouller, F., Evans, P., Lumb, W., Wetherwell, S., Aldegather, J., Oginni, O., Giles, C., Jones, H., Sharp, H., Jefferies, A., Richardson, M., Paul, C., Seamark, D., Tragen, D., Taylor, G., St Joseph, V, Thompson, J., Fairhead, S., Franklin, S., Wilson, P., Ramesh, C., Aziz, M., Paul, N., Stokes, M., Wakeman, A., Hutchinson, P., Bilas, R., Sircar, S., Singal, A., Suryani, S., Wagner, H., Gooding, T., Williams, A., McDonnell, J., Pickavance, G., Kainth, M. S., Ross, A., Jhittay, P. S., Leese, J., Evans, R., Saunders, P., Goodwin, D., Chauhan, N., Fitzmaurice, D., Varenov, V., Todoriuk, L., Stets, R., Shumakov, O., Sapatyi, A., Romanova, O., Romanenko, O., Rasputina, L., Pyvovar, S., Proshak, O., Plevak, D., Petrovskyy, R., Pavelko, M., Palamarchuk, O., Ovdiienko, T., Nemtsova, V, Mospan, M., Mochonyi, V, Medentseva, O., Matova, O., Kizim, S., Khyzhnyak, O., Kaplan, P., Kamenska, E., Ivanov, A., Daniuk, I, Chabanna, O., Burdeuna, L., Berko, G., Belegai, R., Fushtey, I, Tykhonova, S., Yagensky, A., Kraydashenko, O., Stanislavchuk, M., Sychov, O., Svyshchenko, Y., Kovalskyi, I, Koval, O., Ushakov, O., Mostovoy, Y., Serediuk, N., Kupnovytska, I, Kraiz, I, Zhurba, S., Karpenko, O., Tseluyko, V, Rudyk, I, Parkhomenko, A., Winnik, S., Saga, E., Henriette, I, Guinand, A., Grau, A., Elise, G., Bruegger, J., Amstutz, D., Debrunner, J., Beer, J. H., Steffel, J., Thorsen, C., Stjernberg, M., Skoglund, K., Shayesteh, M., Samuelsson, J., Rosenberg, K., Risbecker, K., Pedersen, A., Osberg, A., Olofsson, A., Ohlin, A-M, Nilsson, C., Millborg, M., Mansson, K., Mannermyr, A., Lindholm, C-J, Lindberg, A., Lettenstrom, A., Kusiak, D., Koch, A., Kangert, R-M, Jansson, J-H, Jansson, B., Jaensson, P., Hahn, S., Grassjo, C., Floren, K., Eriksson, G-B, Ekstrand, A-B, Dzeletovic, S., Bonkowski, G., Al-Khalili, F., Ahlmark, H., Ahbeck, E., Aaroe, H., Stalby, P., Hot-Bjelac, A., Thulin, J., Engdahl, J., Bernsten, F., Martinsson, B., Malmqvist, L., Andersson, A., Jensen, S. A., Karlsson, J-E, Crisby, M., Romberg, K., Timberg, I, Eriksson, B., Platonov, P., Handel, H., Thorne, K., Svensson, P., Lindvall, H., Ohlsson, A., Ericsson, M., Kadir, K., Hajimirsadeghi, A., Bothin, C., Benson, L., Andersson, L. (Lisbeth), Andersson, L. 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J., Novas, V, Navarro, A., Vercammen, J., Purnode, P., Blankoff, I, Araminowicz, J., Andrzejewski, D., Ambicka, M., Gaona Rodriguez, R., Villeda Espinosa, E., Lesnik, J., Nessler, J., Faes, D., Domanska, E., Balthazar, Y., Raczak, G., Beutels, M., Rusicka-Piekarz, T., Baszak, J., Lysek, R., Mazur, S., Myszka, W., Flores Martinez, D., Miekus, P., Jurowiecki, J., Cymerman, K., Galbas, K., Wozniak-Skowerska, I, Nagibovich, G., Kukla, P., Marechal, P., Okopien, B., Velasco Barcena, J., Yong, R., Sciborski, R., Jaworska, K., Ruszkowski, P., Glanowska, G., Ogorek, M. (Michal), Verstraete, S., Munguia, R., Meirino, A., Mautner, B., Matkovich, J., Rodriguez Briones, I, Martinelli, C., Leiva Pons, J. L., Martinelli, A., Maffei, L., Alvarez Lopez, H., Olvera Ruiz, R., Maehara, G., Lopez, A., Ingratta, M., Diaz de la Vega, C., Cantu Brito, C., Chuquiure Valenzuela, E., Reyes-Sanchez, R., Hrabar, A. D., Bazzoni Ruiz, A., Nandayapa Flores, O., Benavides Gonzalez, M., Arriaga Nava, R., Hansen, V, Had, M. de L. M., Xhaet, O., Gurfinkel, E. P., Morales Cerda, J. D., Fierro Fierro, O., Gimenez, C. H., Fajardo Campos, P., Alfaro, T. A. A., Giacomi, M. P., Altamirano Bellorin, S., Funosas, C., Avena, R., Foa Torres, M., Fernandez Voena, F., Fanuele, M., Eden, M. F., Diez, F., De Urquiza, I. N., Damonte, A. A., Costamagna, O. J. A., Costabel, J. P., Chavarria, M., Espinosa, I, Colombo Berra, F., Carrizo, R., Cappi, A. L., Campisi, V, Cabrini, R., Flores Silva, F., Buzzetti, C., Garcia Nava, R. H., Borchowiec, S., Berli, M., Berli, F., Bergesio, L., Belardi, J. A., Godoy, K., Arias, L., Gonzalez Felix, E. J., Gonzalez Garcia, C. L., Striekwold, H., Gonzalez Salas, L. G., Guajardo, P., Arabetti, C., Hernandez Gonzalez, S., Alvarez D'Amelio, A., Izquierdo, T., Mancilla Ortiz, M. C., Martinez Vasquez, D., Mendoza, N., Morales, J., Nikitina, N., Ochoa Aybar, S., Ortiz, A., Padilla Macias, P., Perez, F., Perez Sanchez, J. A., Pina Toledano, S., Alaguibe, E. D., Rivera Ramos, C., Roa Castro, V, Romero Cardona, G., Ruiz Cornejo, M., Salinas, A., Ferroni, F., Santana, G., Sida Perez, P., Thoeng, J., Gomez Vilamajo, O. A., Tovar Castaneda, A. C., Hermans, K., Trujillo Cortes, R., Brodmann, M., Motylev, I, Bronisz, M., Lenz, K., Drexel, H., Berli, M. A., Foechterle, J., Opolski, G., Hagn, C., Trusz-Gluza, M., Chmielnicka-Pruszczynska, M., Alzand, B., Ascoop, A-K, Karczmarczyk, A., Zinka, E., Lewczuk, J., Banaeian, F., Ostrowska-Pomian, B., Lajkowski, Z., Krzciuk, M., Barbuto, A-M, Kania, G., Billiaux, A. C., Blockmans, M., Olszewski, M., Minc, P., Gruchala, M., Bouvy, C., Kucharski, L., Swiatkowska-Byczynska, L., Hiczkiewicz, J., Brike, C., Capiau, H., Zaluska, R., Kuzniar, J., Cartasegna, L. R., Sinisi, V. A., Sassone, S., Fosco, M. J., Fernandez, A. 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Hoegh, Oien, T., Christersson, P., Kolodzinska, A., Kirchner-Volker, K., Svilaas, A., Klein, V, Kroll, D., Ghezai, B., Krueger, A., Lehmann, R., Mann, L., Maselli, A., Menken, G., Mikes, K., Mortan, H., Nasser, N., Nicolaus, D., Plauskat, A., Pomper, L., Quietzsch, A., Ravenhorst, C., Komlo, A., Konopka, A., Korczowska, E., Kowal, E., Kowalczyk, H. K., Kremis, E., Kruczyk, D., Krzesiak-Lodyga, A., Krzyzanowski, M., Kurdzielewicz, W., Kustrzycka-Kratochwil, D., Lesniewska-Krynska, D., Leszczynski, J., Lewicka, E., Lichota, E., Lip, K., Loboz-Rudnicka, M., Luka, J., Volodicheva, O., Zemlianskaia, O., Zhirov, I, Lysek-Jozefowicz, A., Machnikowska, M., Majewska, K., Mariankowski, R., Ostrem, A., Skjelvan, G., Hallaraker, A., Markiewicz, A., Erga, K., Hole, T., Gjertsen, E., Sirnes, P. A., Mazur, M., Metzgier-Gumiela, A., Berge, E., Atar, D., Westerman, L., van Putten, J. J., van Leeuwen, G., van der Kley, T., Miedlar, E., van de Loo, R., Mielcarek, M., Neubauer-Geryk, J., Monako, G., Medvedeva, T., Machilskaya, O., Lileeva, E., Lebedeva, O., Niedek, J., Niemirycz-Makurat, A., Kuvanova, M., Kurylo, B., Kupriyanova, T., Kungurtseva, O., Kuchuk, P., Kropova, O., Nowak, A., Nowak, S., Zhuravleva, E., Zotova, I, Korneeva, O., Konyushenko, D., Vinolas, X., Alvarez Garcia, P., Kolesova, T., Ivanova, Y., Lopez Fernandez, M. F., Gurmach, M., Tercedor, L., Gubanov, A., Tranche Iparraguirre, S., Toran Monserrat, P., Marquez Contreras, E., Isart Rafecas, J., Motero Carrasco, J., Gorshkova, T., Opielowska-Nowak, B., Garcia Pavia, P., Gomez Pajuelo, C., Moro Serrano, C., Gorbunova, E., Iglesias Alonso, L. F., Erofeeva, S., Grande Ruiz, A., Ozgowicz, M., Pawelska-Buczen, A., Merce Klein, J., Gonzalez Juanatey, J. R., Baron Esquivias, G., Monte Collado, I, Palacin Piquero, H., Brotons Cuixart, C., Rodriguez Morato, M., Llibre, J. Bayo, Corros Vicente, C., Vida Gutierrez, M., Epelde Gonzalo, F., Almeida Fernandez, C. A., Del Val Plana, N., Escriva Montserrat, E., Montero Alia, J. J., Barreda Gonzalez, M., Moleiro Oliva, M. A., Iglesias Sanmartin, J., Jimenez Gonzalez, M., Dumikyan, A., Rodriguez Alvarez, M., Herreros Melenchon, J., Ripoll Vera, T., Ridocci Soriano, F., Garcia Riesco, L., Marco Macian, M. D., Quiles Granado, J., Jimenez Navarro, M., Cosin Sales, J., Vaquer Perez, J. V., Pawlik-Rak, E., Chugunnaya, S., Vazquez Caamano, M., Arcocha Torres, M. F., Marcos Gomez, G., Iniguez Romo, A., Prieto Diaz, M. A., Bitakova, F., Alonso, C. (Carmela), Alonso, C. (Concepcion), Alvarez, D., Alvarez, M., Belenkova, Y., Amaro, M., Andere, N., Aracil Villar, J., Batalov, R., Armitano Ochoa, R., Austria, A., Agakhanyan, A., Barbeira, S., Barraquer Feu, E., Uppelschoten, B., Reichelt, C., Piotrowicz, R., Tonino, P., Reimer, C., Schaefer, B., Scharrer, S., Schirmer, K., Schmidt, K., Schoene, R., Schulze, J., Schuppe, M., Simon, S., Sommer, S., Spranger, K., Talkenberger, A., Tauber, K., Tetlak, A., Toennishoff, T., Bartes, A., Voigts, B., Weiser, U., Wesendorf, S., Wildenauer, S., Wolf, T., Wurziger, J., Zak, J., Zauzig, H-D, te Kaat, J., Ziefle, S., Zincke, S., Keltai, M., Vangel, S., Szalai, G., Merkely, B., Kancz, S., Boda, Z., Nagy, A., Laszlo, Z., Matoltsy, A., Gaszner, B., Polgar, P., Habon, T., Noori, E., Juhasz, G., Kanakaridisz, N., Szentpeteri, I, Juhasz, F., Vertes, A., Papp, A., May, Z., Stallinga-de Vos, A., Ferenczi, J., Egyutt, M., Engelthaler, G., Fulop, E., Gombos, P., Gulyas, D., Jen, P., Edin, A., Becerra Munoz, V, Gyorke, E. Kiralyhazine, Kovacs, M., Levang, S. Kovacsne, Marianna, S., Radics, Z., Bermudez Jimenez, F. J., Branjovich Tijuan, A., Cabeza Ramirez, J., Cabrera Ramos, M., Calvo Martinez, E., Campo Moreno, M., Cancho Corchado, G., Casanova Gil, M., Castillo Orive, M., Pronk, A., Ptaszynski, P., Raczynska, A., Rogowski, W., Mulder, R., Melman, P., Romanek, J., Romaszkiewicz, R., Krikken, J., Rostoff, P., Roszczyk, N., Rozewska-Furmanek, D., Rychta, J., Koomen, E. M., Rzyczkowska, B., Sidor, A., Skalska, J., Smichura, M., Splawski, M., Staneta, P., Staniszewska, E., Starak-Marciniak, J., Stopyra-Poczatek, M., Sukiennik-Kujawa, M., Szafranski, J., Szalecki, P., Szczepanska, A., Szkrobka, W., Szuchnik, E., Szulowska, A., Kloosterman, T., Kelderman, M., Szumczyk-Muszytowska, G., Szwoch, M., Jetten, W., Traczyk, T., Troszczynska, M., Trzcinski, G., Tybura, S., Walasik, P., Wegrzynowska, M., Wesolowska, K., Wieczorek, W., Wierzbicka, A., Wilczewski, P., Wilgat-Szecowka, M., Wojewoda, P., Wojnowski, L., Wrobel, M., Zakutynska-Kowalczyk, K., Zyczynska-Szmon, M., Panchenko, E., Eltishcheva, V, Libis, R., Tereshchenko, S., Popov, S., Kamalov, G., Belenky, D., Zateyshchikova, A., Kropacheva, E., Kolesnikova, A., Nikolaev, K., Egorova, L., Khokhlov, A., Yakupov, E., Poltavskaya, M., Zateyshchikov, D., Drapkina, O., Vishnevsky, A., Barbarash, O., Miller, O., Aleksandrova, E., Chizhov, P., Sydo, N., Szalo, R., Szilagyi, A., Sergeev, M., Sztanyik, F., Shutemova, E., Vandrus, B., Agnelli, G., Mazur, E., Ambrosio, G., Tiraferri, E., Santoro, R., Testa, S., Di Minno, G., Moia, M., Caimi, T. M., Martini, G., Tessitori, M., Cappelli, R., Poli, D., Quintavalla, R., Melone, F., Cosmi, F., Pizzini, A., Piseddu, G., Fanelli, R., Latella, C., Santi, R., Pancaldi, L., De Cristofaro, R., Palareti, G., De Blasio, A., Zrazhevskiy, K., Novikova, T., Kostenko, V, Moiseeva, Y., Polkanova, E., Uriarte, J. Salerno, Minetti, F., Pogliani, E. M., Lonati, L. M., Accogli, M., Ciampani, N., Malengo, S., Feola, M., Raisaro, A., Fattore, L., Grilli, P., Germini, F., Settimi, M., Alunni, M., Sobolev, K., Rossovskaya, M., Duranti, G., Tedeschi, L., Zubeeva, G., Shapovalova, Y., Baglioni, G., Avanzino, G., Berardi, M., Pannacci, V, Giombolini, A., Nicoli, S., Scarponi, T., Allasia, B., Ricciarini, P., Nasorri, R., Argena, A., Bossolasco, P., Ronchini, P., Filippi, A., Tradati, F., Bulla, C., Donzelli, L., Foppa, L., Bottarelli, M. L., Tomasello, A., Mauric, A., Femiano, C., Reggio, R., Lillo, F., Mariani, A., Forcignano, F., Volpe, M., D'Avino, M., Yildirim, E., Yildirim, R., Bongiorni, M. G., Severi, S., Capucci, A., Lodigiani, C., Salomone, E., Serviddio, G., Tondo, C., Golino, P., Mazzone, C., Iacopino, S., Pengo, V, Galvani, M., Moretti, L., Ambrosino, P., Banfi, E., Biagioli, V, Bianchi, A., Boggian, G., Breschi, M., Brusorio, S., Ball, K., Calcagnoli, F., Campagna, G., Page, M., Renom, R., Jimeno Besa, B., Carpenedo, M., Ciabatta, C., Ciliberti, G., Kis, E., Cimmino, G., Ramos Gonzalez, M., Vieira Torres, L. G., Sucu, M., Chattranukulchai, P., Cho, J-G, D'Arienzo, C., Di Gennaro, L., Fedele, M., Ferrini, P. M., Jerzewski, A., Gorrebeeck, K., Geerlings, F., Dols, S., Debordes, M., de Graauw, J., De Graaf, J., Granzow, K., Danse, I, Bruin, S., Bosschaert, M., Bosman, F., Boersma-Slootweg, M., Boersma, L. V. A., Buiks, C., Terpstra, W., Groenemeijer, B. E., Nagibovich, O., Hermans, W., Guazzaloca, G., Hoogslag, P. A. M., Nierop, P. R., Guerra, F., The, S. H. K., Adriaansen, H., Lucassen, A., Lochorn, G., Herrman, J-P, Guldener, C., Pieterse, M. G. C., Bongaerts, M., Klomps, H., Ruiter, J. H., ten Cate, H., Zecca, C., Villani, R., Sottilota, G., Segreti, L., Scarone, C., Scaccianoce, A., Salomone, L., Rangel, G., Oriana, V, Occhilupo, P., Poeta, E. Mollica, Mesolella, E., Macellari, F., Longo, S., Lo Buglio, A., Tao, G. Z., Rosenqvist, Marten, Kasala, L., Oto, Ali, He, X. A., Zhou, B., Vinolas, Xavier, Kakkar, Ajay K., Fitzmaurice, David A., Fox, Keith A. A., Kayani, Gloria, Virdone, Saverio, Camm, A. John, and Pieper, Karen S. more...
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medicine.medical_specialty ,business.industry ,Systemic embolism ,Atrial fibrillation ,Newly diagnosed ,Meth ,ta3121 ,medicine.disease ,chemistry.chemical_compound ,chemistry ,Physiology (medical) ,Internal medicine ,Antithrombotic ,Cardiology ,Medicine ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business ,Stroke ,Major bleeding - Abstract
Background: Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. Methods: We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their relation to the time after diagnosis of atrial fibrillation in 52 014 patients prospectively enrolled in the GARFIELD-AF registry (Global Anticoagulant Registry in the FIELD–Atrial Fibrillation) between March 2010 and August 2016. Results: Over 12 months, 2140 patients died (mortality rate, 4.3; 95% CI, 4.2–4.5 per 100 person-years), of whom 288 (13.5%) died in the first month (6.8; 95% CI, 6.1–7.6). Over 12 months, 657 patients had a stroke/systemic embolism (1.3; 95% CI, 1.2–1.4) and 411 had a major bleeding (0.8; 95% CI, 0.8–0.9). During the first month, the rates (per 100 person-years) of stroke/systemic embolism and major bleed were 2.3 (95% CI, 1.9–2.8) and 1.5 (95% CI, 1.2–1.9), respectively. The elevated 1-month mortality rate was mostly attributable to cardiovascular mortality (3.5; 95% CI, 3.0–4.1), in particular, heart failure, sudden death, and acute coronary syndromes (1.0 [95% CI, 0.8–1.4], 0.6 [95% CI, 0.4–0.8], and 0.5 [95% CI, 0.3–0.8], respectively). Age, heart failure, prior stroke, history of cirrhosis, vascular disease, moderate-to-severe kidney disease, diabetes mellitus, and living in North or Latin America were independent predictors of a higher risk of early death, whereas anticoagulation and living in Europe or Asia were independent predictors of a lower risk of early death. A predictive model developed for the 1-month risk of death had a C-statistic of 0.81 (95% CI, 0.78–0.83). Conclusions: The increased hazard of early events, in particular, cardiovascular mortality, in newly diagnosed atrial fibrillation points to the importance of comprehensive care for such patients and should alert clinicians to detect warning signs of possible early mortality. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01090362. more...
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- 2019
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14. Comparison of HBV RNA and Hepatitis B Core Related Antigen With Conventional HBV Markers Among Untreated Adults With Chronic Hepatitis B in North America
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Ghany, Marc G., primary, King, Wendy C., additional, Lisker‐Melman, Mauricio, additional, Lok, Anna S.F., additional, Terrault, Norah, additional, Janssen, Harry L.A., additional, Khalili, Mandana, additional, Chung, Raymond T., additional, Lee, William M., additional, Lau, Daryl T.Y., additional, Cloherty, Gavin A., additional, and Sterling, Richard K., additional more...
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- 2021
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15. Reply to Li, Henry, and Nguyen
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Mandana, Khalili, David E, Kleiner, Wendy C, King, Richard K, Sterling, Marc G, Ghany, Raymond T, Chung, Atul K, Bhan, Philip, Rosenthal, Mauricio, Lisker-Melman, Rageshree, Ramachandran, and Anna S, Lok more...
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Hepatology ,Gastroenterology - Published
- 2022
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16. The Effects of a Genital Vibratory Stimulation Device on Sexual Function and Genital Sensation
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Marsha K. Guess, Arnold Melman, Kayla E. Nixon, Katherine Freeman, S. Chudnoff, Olusola Adekoya, Kathleen A. Connell, and Cherrilyn F. Richmond
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Adult ,medicine.medical_specialty ,medicine.biofluid ,Sexual Behavior ,Urology ,media_common.quotation_subject ,Sexual arousal ,030232 urology & nephrology ,Electric Stimulation Therapy ,Orgasm ,Vibration ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Sensation ,medicine ,Humans ,Sex organ ,Prospective Studies ,media_common ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Vaginal lubrication ,Obstetrics and Gynecology ,Genitalia, Female ,Middle Aged ,Sexual Dysfunction, Physiological ,Distress ,Sexual dysfunction ,Female ,Surgery ,medicine.symptom ,business ,Sexual function - Abstract
OBJECTIVE The aim of this study was to evaluate the effectiveness of a genital vibratory stimulation device in improving sexual function in women with arousal and orgasm disorders. METHODS In this single-arm, prospective study, baseline and 1- and 3-month assessments were performed to evaluate women with sexual arousal and/or orgasmic disorders, who received therapy using a genital vibratory stimulation device. Sexual function, satisfaction, and distress were evaluated using the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale, and the Female Intervention Efficacy Index questionnaires. Genital sensation was evaluated using quantitative sensory testing. RESULTS Seventy women, aged 19 to 64 years, were evaluated from October 2009 to August 2013. Forty-seven (67.1%) and 37 (52.9%) women completed 1- and 3-month follow-ups, respectively. The FSFI arousal and orgasm domain scores and total FSFI scores improved at 1 and 3 months (P < 0.001 for all outcomes). Mean (SD) total FSFI scores increased from 20.04 (4.65) (baseline) to 25.03 (5.21) (1 month) to 26.66 (5.42) (3 months; both Ps < 0.0001). Female Sexual Distress Scale scores reflected significantly decreased distress at 1 (P = 0.0006) and 3 (P < 0.0001) months compared with baseline and at 3 months compared with 1 month (P = 0.03). Neurological sensation was increased at all genital sites at 1 and 3 months (P < 0.0001 for all). After adjustment for age, there was a significant interaction between arousal domain scores and clitoral and right labial sensation. At 3 months, perceptions of increased vaginal lubrication, orgasm, and genital sensation were reported by 67.5%, 65.0%, and 82.5% of the participants. No major adverse events were noted. CONCLUSIONS Genital vibratory stimulation device use resulted in uniform improvements in sexual function, satisfaction, sexually related distress and genital sensation. more...
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- 2017
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17. Management and 1‐Year Outcomes of Patients With Newly Diagnosed Atrial Fibrillation and Chronic Kidney Disease: Results From the Prospective GARFIELD‐AF Registry
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Goto, Shinya, primary, Angchaisuksiri, Pantep, additional, Bassand, Jean‐Pierre, additional, Camm, A. John, additional, Dominguez, Helena, additional, Illingworth, Laura, additional, Gibbs, Harry, additional, Goldhaber, Samuel Z., additional, Goto, Shinichi, additional, Jing, Zhi‐Cheng, additional, Haas, Sylvia, additional, Kayani, Gloria, additional, Koretsune, Yukihiro, additional, Lim, Toon Wei, additional, Oh, Seil, additional, Sawhney, Jitendra P. S., additional, Turpie, Alexander G. G., additional, van Eickels, Martin, additional, Verheugt, Freek W. A., additional, Kakkar, Ajay K., additional, Fitzmaurice, David A., additional, Hacke, Werner, additional, Mantovani, Lorenzo G., additional, Misselwitz, Frank, additional, Pieper, Karen S., additional, Fox, Keith A. A., additional, Gersh, Bernard J., additional, Luciardi, Hector Lucas, additional, Brodmann, Marianne, additional, Cools, Frank, additional, Barretto, Antonio Carlos Pereira, additional, Connolly, Stuart J., additional, Spyropoulos, lex, additional, Eikelboom, John, additional, Corbalan, Ramon, additional, Hu, Dayi, additional, Jansky, Petr, additional, Nielsen, Jørn Dalsgaard, additional, Ragy, Hany, additional, Raatikainen, Pekka, additional, Le Heuzey, Jean‐Yves, additional, Darius, Harald, additional, Keltai, Matyas, additional, Kakkar, Sanjay, additional, Agnelli, Giancarlo, additional, Ambrosio, Giuseppe, additional, Sánchez Díaz, Carlos Jerjes, additional, Ten Cate, Hugo, additional, Atar, Dan, additional, Stepinska, Janina, additional, Panchenko, Elizaveta, additional, Jacobson, Barry, additional, Viñolas, Xavier, additional, Rosenqvist, Marten, additional, Steffel, Jan, additional, Oto, Ali, additional, Parkhomenko, Alex, additional, Mahmeed, Wael Al, additional, Fitzmaurice, David, additional, Chen, K. N., additional, Zhao, Y. S., additional, Zhang, H. Q., additional, Chen, J. Z., additional, Cao, S. P., additional, Wang, D. W., additional, Yang, Y. J., additional, Li, W. H., additional, Yin, Y. H., additional, Tao, G. Z., additional, Yang, P., additional, Chen, Y. M., additional, He, S. H., additional, Wang, Y. (Ying), additional, Wang, Y. (Yong), additional, Fu, G. S., additional, Li, X., additional, Wu, T. G., additional, Cheng, X. S., additional, Yan, X. W., additional, Zhao, R. P., additional, Chen, M. S., additional, Xiong, L. G., additional, Chen, P., additional, Jiao, Y., additional, Guo, Y., additional, Xue, L., additional, Wang, F. Z., additional, Li, H., additional, Yang, Z. M., additional, Bai, C. L., additional, Chen, J., additional, Chen, J. Y., additional, Chen, X., additional, Feng, S., additional, Fu, Q. H., additional, Gao, X. J., additional, Guo, W. N., additional, He, R. H., additional, He, X. A., additional, Hu, X. S., additional, Huang, X. F., additional, Li, B., additional, Li, J., additional, Li, L., additional, Li, Y. H., additional, Liu, T. T., additional, Liu, W. L., additional, Liu, Y. Y., additional, Lu, Z. C., additional, Luo, X. L., additional, Ma, T. Y., additional, Peng, J. Q., additional, Sheng, X., additional, Shi, X. J., additional, Sun, Y. H., additional, Tian, G., additional, Wang, K., additional, Wang, L., additional, Wu, R. N., additional, Xie, Q., additional, Xu, R. Y., additional, Yang, J. S., additional, Yang, L. L., additional, Yang, Q., additional, Ye, Y., additional, Yu, H. Y., additional, Yu, J. H., additional, Yu, T., additional, Zhai, H., additional, Zhan, Q., additional, Zhang, G. S., additional, Zhang, Q., additional, Zhang, R., additional, Zhang, Y., additional, Zheng, W. Y., additional, Zhou, B., additional, Zhou, Z. H., additional, Zhu, X. Y., additional, Oda, H. (Hiroshi), additional, Nakamura, (Tadashi), additional, Nakamura, T. (Tsugihiro), additional, Fujiura, Y. (Yoshihisa), additional, Saito, K. (Katsumi), additional, Saito, K. (Kazuyuki), additional, Fujiura, Y. (Yoshitake), additional, Nakamura, Y. (Yoichi), additional, Oda, H. (Hiroyuki), additional, Morii, S., additional, Shiga, Y. (Yuhei), additional, Nii, K., additional, Nakamura, Y. (Yuichiro), additional, Fujii, M., additional, Abe, M. (Masahiko), additional, Abe, M. (Masatake), additional, Abe, M. (Mitsunori), additional, Saito, T., additional, Mito, T., additional, Nagao, K., additional, Minami, J., additional, Mita, T., additional, Sakuma, I., additional, Taguchi, T., additional, Marusaki, S., additional, Doi, H., additional, Tanaka, M., additional, Fujito, T., additional, Matsuta, M., additional, Kusumoto, T., additional, Kakinoki, S., additional, Ashida, K., additional, Yoshizawa, N., additional, Agata, J., additional, Arasaki, O., additional, Manita, M., additional, Ikemura, M., additional, Fukuoka, S., additional, Murakami, H., additional, Matsukawa, S., additional, Hata, Y., additional, Taniguchi, T., additional, Ko, T., additional, Kubo, H., additional, Imamaki, M., additional, Akiyama, M., additional, Inagaki, M., additional, Odakura, H., additional, Ueda, T., additional, Katsube, Y., additional, Nakata, A., additional, Watanabe, H., additional, Techigawara, M., additional, Igarashi, M., additional, Taga, K., additional, Kimura, T., additional, Tomimoto, S., additional, Shibuya, M., additional, Nakano, M., additional, Ito, K., additional, Seo, T., additional, Hiramitsu, S., additional, Hosokawa, H., additional, Hoshiai, M., additional, Hibino, M., additional, Miyagawa, K., additional, Horie, H. (Hajime), additional, Sugishita, N., additional, Shiga, Y. (Yukio), additional, Soma, A., additional, Neya, K., additional, Yoshida, T. (Tetsuro), additional, Yoshida, T. (Tomoki), additional, Mizuguchi, M., additional, Ishiguro, M., additional, Minagawa, T., additional, Wada, M., additional, Mukawa, H., additional, Okuda, F., additional, Nagasaka, S., additional, Abe, Y., additional, Adachi, S. (Sen), additional, Adachi, S. (Susumu), additional, Adachi, T., additional, Akahane, K., additional, Amano, T., additional, Aoki, K., additional, Aoyama, T., additional, Arai, H., additional, Arima, S., additional, Arino, T., additional, Asano, H., additional, Asano, T., additional, Azuma, J., additional, Baba, T., additional, Betsuyaku, T., additional, Chibana, H., additional, Date, H., additional, Doiuchi, J., additional, Emura, Y., additional, Endo, M., additional, Fujii, Y., additional, Fujiki, R., additional, Fujisawa, A., additional, Fujisawa, Y., additional, Fukuda, T., additional, Fukui, T., additional, Furukawa, N., additional, Furukawa, T., additional, Furumoto, W., additional, Goto, T., additional, Hamaoka, M., additional, Hanazono, N., additional, Hasegawa, K., additional, Hatsuno, T., additional, Hayashi, Y., additional, Higuchi, K., additional, Hirasawa, K., additional, Hirayama, H., additional, Hirose, M., additional, Hirota, S., additional, Honda, M., additional, Horie, H. (Hideki), additional, Ido, T., additional, Iiji, O., additional, Ikeda, H., additional, Ikeda, K., additional, Ikeoka, K., additional, Imaizumi, M., additional, Inaba, H., additional, Inoue, T., additional, Iseki, F., additional, Ishihara, A., additional, Ishioka, N., additional, Ito, N., additional, Iwase, T., additional, Kakuda, H., additional, Kamata, J., additional, Kanai, H., additional, Kanda, H., additional, Kaneko, M., additional, Kano, H., additional, Kasai, T., additional, Kato, T., additional, Kato, Y., additional, Kawada, Y., additional, Kawai, K., additional, Kawakami, K., additional, Kawakami, S., additional, Kawamoto, T., additional, Kawano, S., additional, Kim, J., additional, Kira, T., additional, Kitazawa, H., additional, Kitazumi, H., additional, Kito, T., additional, Kobayashi, T., additional, Koeda, T., additional, Kojima, J., additional, Komatsu, H., additional, Komatsu, I., additional, Koshibu, Y., additional, Kotani, T., additional, Kozuka, T., additional, Kumai, Y., additional, Kumazaki, T., additional, Maeda, I., additional, Maeda, K., additional, Maruyama, Y., additional, Matsui, S., additional, Matsushita, K., additional, Matsuura, Y., additional, Mineoi, K., additional, Mitsuhashi, H., additional, Miura, N., additional, Miyaguchi, S., additional, Miyajima, S., additional, Miyamoto, H., additional, Miyashita, A., additional, Miyata, S., additional, Mizuguchi, I., additional, Mizuno, A., additional, Mori, T., additional, Moriai, O., additional, Morishita, K., additional, Murai, O., additional, Nagai, S. (Sho), additional, Nagai, S. (Shunichi), additional, Nagata, E., additional, Nagata, H., additional, Nakagomi, A., additional, Nakahara, S., additional, Nakamura, M., additional, Nakamura, R., additional, Nakanishi, N., additional, Nakayama, T., additional, Nakazato, R., additional, Nanke, T., additional, Nariyama, J., additional, Niijima, Y., additional, Niinuma, H., additional, Nishida, Y., additional, Nishihata, Y., additional, Nishino, K., additional, Nishioka, H., additional, Nishizawa, K., additional, Niwa, I., additional, Nomura, K., additional, Nomura, S., additional, Nozoe, M., additional, Ogawa, T., additional, Ohara, N., additional, Okada, M., additional, Okamoto, K., additional, Okita, H., additional, Okuyama, M., additional, Ono, H., additional, Ono, T., additional, Onuki Pearce, Y., additional, Oriso, S., additional, Ota, A., additional, Otaki, E., additional, Saito, Y., additional, Sakai, H., additional, Sakamoto, N., additional, Sakamoto, Y., additional, Samejima, Y., additional, Sasagawa, Y., additional, Sasaguri, H., additional, Sasaki, A., additional, Sasaki, T., additional, Sato, K. (Kazuki), additional, Sato, K. (Kiyoharu), additional, Sawano, M., additional, Seki, S., additional, Sekine, Y., additional, Seta, Y., additional, Sezaki, K., additional, Shibata, N., additional, Shiina, Y., additional, Shimono, H., additional, Shimoyama, Y., additional, Shindo, T., additional, Shinohara, H., additional, Shinohe, R., additional, Shinozuka, T., additional, Shirai, T., additional, Shiraiwa, T., additional, Shozawa, Y., additional, Suga, T., additional, Sugimoto, C., additional, Suzuki, K. (Kazuo), additional, Suzuki, K. (Keita), additional, Suzuki, S. (Shu), additional, Suzuki, S. (Shunji), additional, Suzuki, S. (Susumu), additional, Suzuki, Y., additional, Tada, M., additional, Taguchi, A., additional, Takagi, T., additional, Takagi, Y., additional, Takahashi, K., additional, Takahashi, S., additional, Takai, H., additional, Takanaka, C., additional, Take, S., additional, Takeda, H., additional, Takei, K., additional, Takenaka, K., additional, Tana, T., additional, Tanabe, G., additional, Taya, K., additional, Teragawa, H., additional, Tohyo, S., additional, Toru, S., additional, Tsuchiya, Y., additional, Tsuji, T., additional, Tsuzaki, K., additional, Uchiyama, H., additional, Ueda, O., additional, Ueyama, Y., additional, Wakaki, N., additional, Wakiyama, T., additional, Washizuka, T., additional, Watanabe, M., additional, Yamada, T., additional, Yamagishi, T., additional, Yamaguchi, H., additional, Yamamoto, K. (Kenichi), additional, Yamamoto, K. (Kentaro), additional, Yamamoto, K. (Kunihiko), additional, Yamamoto, T., additional, Yamaura, M., additional, Yamazoe, M., additional, Yasui, K., additional, Yokoyama, Y., additional, Yoshida, K., additional, Ching, C. K., additional, Foo, C. G., additional, Chow, J. H., additional, Chen, D. D., additional, Jaufeerally, F. R., additional, Lee, Y. M., additional, Lim, G., additional, Lim, W. T., additional, Thng, S., additional, Yap, S. Y., additional, Yeo, C., additional, Pak, H. N., additional, Kim, J.‐B., additional, Kim, J. H., additional, Jang, S.‐W., additional, Kim, D. H., additional, Ryu, D. R., additional, Park, S. W., additional, Kim, D.‐K., additional, Choi, D. J., additional, Oh, Y. S., additional, Cho, M.‐C., additional, Kim, S.‐H., additional, Jeon, H.‐K., additional, Shin, D.‐G., additional, Park, J. S., additional, Park, H. K., additional, Han, S.‐J., additional, Sung, J. H., additional, Cho, J.‐G., additional, Nam, G.‐B., additional, On, Y. K., additional, Lim, H. E., additional, Kwak, J. J., additional, Cha, T.‐J., additional, Hong, T. J., additional, Park, S. H., additional, Yoon, J. H., additional, Kim, N.‐H., additional, Kim, K.‐S., additional, Jung, B. C., additional, Hwang, G.‐S., additional, Kim, C.‐J., additional, Kim, D. B., additional, Ahn, J. J., additional, An, H. J., additional, Bae, H., additional, Baek, A. L., additional, Chi, W. J., additional, Choi, E. A., additional, Choi, E. H., additional, Choi, H. K., additional, Choi, H. S., additional, Han, S., additional, Heo, E. S., additional, Her, K. O., additional, Hwang, S. W., additional, Jang, E. M., additional, Jang, H.‐S., additional, Jang, S., additional, Jeon, H.‐G., additional, Jeon, S. R., additional, Jeon, Y. R., additional, Jeong, H. K., additional, Jung, I.‐A., additional, Kim, H. J. (Hyeon Jeong), additional, Kim, H. J. (Hyun Ju), additional, Kim, J. S. (Ji Seon), additional, Kim, J. S. (Jung Sook), additional, Kim, J. A., additional, Kim, K. T., additional, Kim, M. S., additional, Kim, S. H. (Sang Hee), additional, Kim, S. H. (Sang Hyun), additional, Kim, Y.‐I., additional, Lee, C. S., additional, Lee, E. H., additional, Lee, G. H., additional, Lee, H. Y., additional, Lee, H.‐Y., additional, Lee, K. H., additional, Lee, K. R., additional, Lee, M. S., additional, Lee, M.‐Y., additional, Lee, R. W., additional, Lee, S. E., additional, Lee, S. H., additional, Lee, S., additional, Lee, W. Y., additional, Noh, I. K., additional, Park, A. R., additional, Park, B. R., additional, Park, H. N., additional, Park, J. H., additional, Park, M., additional, Park, Y., additional, Seo, S.‐Y., additional, Shim, J., additional, Sim, J. H., additional, Sohn, Y. M., additional, Son, W. S., additional, Son, Y. S., additional, Song, H. J., additional, Wi, H. K., additional, Woo, J. J., additional, Ye, S., additional, Yim, K. H., additional, Yoo, K. M., additional, Yoon, E. J., additional, Yun, S. Y., additional, Chawanadelert, S., additional, Mongkolwongroj, P., additional, Kanokphatcharakun, K., additional, Cheewatanakornkul, S., additional, Laksomya, T., additional, Pattanaprichakul, S., additional, Chantrarat, T., additional, Rungaramsin, S., additional, Silaruks, S., additional, Wongcharoen, W., additional, Siriwattana, K., additional, Likittanasombat, K., additional, Katekangplu, P., additional, Boonyapisit, W., additional, Cholsaringkarl, D., additional, Chatlaong, B., additional, Chattranukulchai, P., additional, Santanakorn, Y., additional, Hutayanon, P., additional, Khunrong, P., additional, Bunyapipat, T., additional, Jai‐Aue, S., additional, Kaewsuwanna, P., additional, Bamungpong, P., additional, Gunaparn, S., additional, Hongsuppinyo, S., additional, Inphontan, R., additional, Khattaroek, R., additional, Khunkong, K., additional, Kitmapawanont, U., additional, Kongsin, C., additional, Naratreekoon, B., additional, Ninwaranon, S., additional, Phangyota, J., additional, Phrommintikul, A., additional, Phunpinyosak, P., additional, Pongmorakot, K., additional, Poomiphol, S., additional, Pornnimitthum, N., additional, Pumprueg, S., additional, Ratchasikaew, S., additional, Sanit, K., additional, Sawanyawisuth, K., additional, Silaruks, B., additional, Sirichai, R., additional, Sriwichian, A., additional, Suebjaksing, W., additional, Sukklad, P., additional, Suttana, T., additional, Tangsirira, A., additional, Thangpet, O., additional, Tiyanon, W., additional, Vorasettakarnkij, Y., additional, Wisaratapong, T., additional, Wongtheptien, W., additional, Wutthimanop, A., additional, Yawila, S., additional, Altun, A., additional, Ozdogru, I., additional, Ozdemir, K., additional, Yilmaz, O., additional, Aydinlar, A., additional, Yilmaz, M. B., additional, Yeter, E., additional, Ongen, Z., additional, Cayli, M., additional, Pekdemir, H., additional, Ozdemir, M., additional, Sucu, M., additional, Sayin, T., additional, Demir, M., additional, Yorgun, H., additional, Ersanli, M., additional, Okuyan, E., additional, Aras, D., additional, Abdelrahman, H., additional, Aktas, O., additional, Alpay, D., additional, Aras, F., additional, Bireciklioglu, M. F., additional, Budeyri, S., additional, Buyukpapuc, M., additional, Caliskan, S., additional, Esen, M., additional, Felekoglu, M. A., additional, Genc, D., additional, Ikitimur, B., additional, Karaayvaz, E. B., additional, Kılıç Karataş, S., additional, Okutucu, S., additional, Ozcelik, E., additional, Quisi, A., additional, Sag, H., additional, Sahiner, L., additional, Sayin, B. Y., additional, Seker, T., additional, Uzun Alkan, D., additional, Yildirim, E., additional, Yildirim, R., additional, Yilmaz, F., additional, Yuksekdag, V., additional, Vensentini, N., additional, Ingaramo, A. C., additional, Sambadaro, G. A., additional, Fernandez Caputi, V., additional, Berman, S. G., additional, Dragotto, P., additional, Kleiban, A. J., additional, Centurion, N., additional, Giacomi, G., additional, Ahuad Guerrero, R. A., additional, Conde, D., additional, Zapata, G., additional, Di Paola, L. A., additional, Ramos, J. L., additional, Dran, R. D., additional, Egido, J., additional, Fernandez, A. A., additional, Fosco, M. J., additional, Sassone, S., additional, Sinisi, V. A., additional, Cartasegna, L. R., additional, Berli, M. A., additional, Gomez Vilamajo, O. A., additional, Ferroni, F., additional, Alaguibe, E. D., additional, D'Amelio, A. Alvarez, additional, Arabetti, C., additional, Arias, L., additional, Belardi, J. A., additional, Bergesio, L., additional, Berli, F., additional, Berli, M., additional, Borchowiec, S., additional, Buzzetti, C., additional, Cabrini, R., additional, Campisi, V., additional, Cappi, A. L., additional, Carrizo, R., additional, Colombo Berra, F., additional, Costabel, J. P., additional, Costamagna, O. J. A., additional, Damonte, A. A., additional, De Urquiza, I. N., additional, Diez, F., additional, Edén, M. F., additional, Fanuele, M., additional, Fernandez Voena, F., additional, Foa Torres, M., additional, Funosas, C., additional, Giacomi, M. P., additional, Gimenez, C. H., additional, Gurfinkel, E. P., additional, Had, M. de L. M., additional, Hansen, V., additional, Hrabar, A. D., additional, Ingratta, M., additional, Lopez, A., additional, Maehara, G., additional, Maffei, L., additional, Martinelli, A., additional, Martinelli, C., additional, Matkovich, J., additional, Mautner, B., additional, Meirino, A., additional, Munguia, R., additional, Navarro, A., additional, Novas, V., additional, Prados, G. Perez, additional, Pontoriero, J., additional, Potito, R. N., additional, Ricotti, C., additional, Rodriguez, M. A., additional, Rolandi, F., additional, Palladino, . E. Said, additional, Salinger, M., additional, Sanziani, L. S., additional, Schygiel, P. O., additional, Sossich, A., additional, Tinto, J. F., additional, Tonelli, L., additional, Tufare, A. L., additional, Vallejo, M., additional, Yunis, M. E., additional, Zillo, M., additional, Zurbrigk, F. J., additional, Sobral Filho, D. C., additional, Jaber, J., additional, Armaganijan, D., additional, Faria Neto, J., additional, Steffens, A., additional, de Souza, W. Kunz Sebba Barroso, additional, de Souza Neto, J. D., additional, Ribeiro, J. M., additional, Silveira Teixeira, M., additional, Ferreira Rossi, P. R., additional, Pires, L., additional, Moreira, D., additional, Moura Jorge, J. C., additional, Lorga Filho, A. Menezes, additional, Bodanese, L. C., additional, Montera, M. Westerlund, additional, Del Carlo, C. H., additional, Da Rocha Rodrigues, T., additional, Alves da Costa, F. A., additional, Lopes, A., additional, Lopes, R., additional, Araújo, G. R., additional, Fernandes Manenti, E. R., additional, Kerr Saraiva, J. F., additional, Ferreira Braga, J. C., additional, Negri, A., additional, Souto, L., additional, Moncada, C., additional, Precoma, D. Bertolim, additional, Roquette, F., additional, Reis, G., additional, Ramos Filho, R. A., additional, Figueiredo, E. Lanna, additional, Botelho, R. Vieira, additional, Tavares, C. Munhoz da Fontoura, additional, Costantini Frack, C. R., additional, Abdalla Saad, J., additional, Finimundi, H. C., additional, Pisani, C., additional, Chemello, D., additional, Pereira Martins, M., additional, Broilo França, C. C., additional, Alban, F., additional, Aranha Rosito, G. B., additional, de Moura Xavier Moraes Junior, J. B., additional, Tumelero, R. T., additional, Maia, L. Nigro, additional, de Almeida, R. Simões, additional, do Carmo Borges, N. C., additional, Gomes Ferreira, L. G., additional, Agliardi, P., additional, de Oliveira Gomes, J. Alves, additional, Araujo, V., additional, Nakazone, M. Arruda, additional, Barbosa, T., additional, Barroso, S., additional, Falchetto, E. Belisario, additional, Lopes, H. Bellotti, additional, Benez Teixeira Lemos, M. A., additional, Biazus, G., additional, Borges Queiroz, L., additional, Camazzola, F. E., additional, Caporale, M., additional, Boscato, S. Cardoso, additional, Chieza, F., additional, Chokr, M. O., additional, Mingireanov, R. Clemente, additional, Góes, N. Codonho, additional, Correa, C., additional, Costa, M., additional, Costantini Ortiz, C., additional, da Silva, L. S., additional, da Silva Paulitsch, F., additional, da Silveira, J. A., additional, Daros, E., additional, de Araújo, G. R., additional, Del Monaco, M. I., additional, Dias, C., additional, Dias, M. A., additional, Drummond Wainstein, A. P., additional, Pizzato, P. Ely, additional, Esteves, D. C., additional, Fabri, P., additional, Félix Lorenzato Fonseca, T., additional, Fernandes, E., additional, Fonseca, C., additional, Costantini, C. R. Frack, additional, Ferraz, R. Franchin, additional, Freire, F., additional, Gottardo, P., additional, Guanaes, D., additional, Guizzardi, S., additional, Magedanz, E. Hettwer, additional, Igansi, F., additional, Jannuzzi, F., additional, Junior, G., additional, Komar, D., additional, Lino, E. G., additional, Lopes, D., additional, da Silva Júnior, O. Lourenço, additional, Lustosa, E., additional, Macagnan, A. P., additional, Marinho, M. C., additional, Mazzoni, M., additional, Melo, G., additional, Mortari, L., additional, Mouco, O. M. C. C., additional, Nanzer Vital, C., additional, Ormundo, C., additional, Oss Emmer, S., additional, Palmegiani, E., additional, Pavani, R., additional, Pereira, L., additional, Pereira, V. L., additional, Perreira, R., additional, Poletti, S., additional, Quaia Fortunato, S. C., additional, Queirantes, C., additional, Pereira, N. Ramos, additional, Rech, R. L., additional, Ribeiro, S., additional, Rodrigues, A., additional, Roesch, H., additional, Reichert, T. Ruaro, additional, Santos, D., additional, Santos, I., additional, Santos, M., additional, Seroqui, M. V., additional, Silva, S., additional, Soares, L., additional, Spolaor, L., additional, Stoll, C., additional, Duda, N. Toazza, additional, Trama, L., additional, Unterkircher, B., additional, Valois, M. V., additional, Vargas, T., additional, Viana, T., additional, Vicente, C., additional, Armaganijan, L. Vidal, additional, Homem, R. Vieira, additional, Vieira Torres, L. G., additional, Boas, L. Vila, additional, Guimarães Filho, F. Villaça, additional, Eggers, G., additional, Gutiérrez, C. Bugueño, additional, Arriagada, G., additional, Cardenas, S. Potthoff, additional, Stockins Fernandez, B. A. J., additional, Conejeros, C., additional, Houzvic, C., additional, Cuevas, P. Marin, additional, Montecinos, H., additional, Forero, A., additional, Lanas, F., additional, Gómez, M. Larico, additional, Vilches, G. Charme, additional, Rey, C., additional, Astudillo, C., additional, Aguilar, J., additional, Campisto, Y., additional, Lara, C., additional, Molina, E., additional, Oyarzon, J. Munoz, additional, Olguin, V., additional, Vergara, M., additional, Villan, C., additional, Illescas Diaz, J., additional, Leal Cantú, R., additional, Ramos Zavala, M. G., additional, Cabrera Jardines, R., additional, Espinola Zavaleta, N., additional, Villarreal Umaña, S., additional, López Rosas, E., additional, Llamas Esperón, G., additional, Pozas, G., additional, Cardona Muñoz, E., additional, Matadamas Hernández, N., additional, Leyva Rendón, A., additional, García Hernández, N., additional, de los Ríos Ibarra, M., additional, Virgen Carrillo, L., additional, López Villezca, D., additional, Hernández Herrera, C., additional, López Prieto, J. J., additional, Gaona Rodríguez, R., additional, Villeda Espinosa, E., additional, Flores Martínez, D., additional, Velasco Barcena, J., additional, Yong, R., additional, Rodríguez Briones, I., additional, Leiva Pons, J. 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P., additional, Fedorowsky, A., additional, Casassus, F., additional, Berneau, J.‐B., additional, Chemin, F., additional, Falvo, N., additional, Perron, J.‐M., additional, Poulard, J.‐E., additional, Barreau, A., additional, Beltra, C., additional, Corrihons, E., additional, Decarsin, N., additional, Dubois, B., additional, Ducasse, E., additional, Giry, X., additional, Kemmel, A., additional, Ledure, S., additional, Lemaire, N., additional, Robin, F., additional, Rosolin, N., additional, Sanchez, D., additional, Suissa, A., additional, Königer, G., additional, Purr, J., additional, Gerbaulet, U., additional, Kellner, B.‐T., additional, Kopf, A., additional, Schäfer, T., additional, Zauzig, H., additional, Riegel, P., additional, Hohensee, H., additional, Eißfeller, E., additional, Eder, W., additional, Rehling, G., additional, Glatzel, D., additional, Zutz, S., additional, Heinz, G.‐U., additional, Menke, H., additional, Pustelnik, A., additional, Sandow, P., additional, Ludwig, N., additional, Wiswedel, H., additional, Wildenauer, W., additional, Axthelm, C., additional, Schwarz, T., additional, Babyesiza, A., additional, Stuchlik, G., additional, Zimny, H.‐H., additional, Kropp, M., additional, Kahl, F., additional, Caspar, A., additional, Omankowsky, S., additional, Läßig, T., additional, Hartmann, H.‐J., additional, Lehmann, G., additional, Bindig, H.‐W., additional, Hergdt, G., additional, Reimer, D., additional, Hauk, J., additional, Dorsch, W., additional, Dshabrailov, J., additional, Michel, H., additional, Rapp, K.‐A., additional, Vormann, R., additional, Mayer, P., additional, Horstmeier, U., additional, Eissing, V., additional, Hey, H., additional, Leuchtgens, H., additional, Lilienweiß, V., additional, Kolitsch, K., additional, Schubert, C., additional, Lauer, H., additional, Buchner, T., additional, Brauer, G., additional, Kamin, S., additional, Müller, K., additional, Abdel‐Qader, M., additional, Baumbach, S., additional, Ebert, H.‐H., additional, Schwencke, C., additional, Schellong, S., additional, Bernhardt, P., additional, Karolyi, L., additional, Sievers, B., additional, Haverkamp, W., additional, Salbach, P., additional, Röhnisch, J.‐U., additional, Schoen, S., additional, Erdle, W., additional, Mueller, T., additional, Mueller, H., additional, Mitrovic, V., additional, Babjakova, Z., additional, Bergner, K., additional, Boehme, S., additional, Bonin, K., additional, Buckert, D., additional, Busch, F., additional, Dichristin, U., additional, Diez, S., additional, Fleck, A., additional, Flint, K., additional, Floegel, H., additional, Fritz, C., additional, Frommhold, R., additional, Gehre, J., additional, Geyer, J., additional, Grytzmann, A., additional, Hahn, M., additional, Helgert, K., additional, Hubert, K., additional, Kirchner‐Volker, K., additional, Klein, V., additional, Kroll, D., additional, Krueger, A., additional, Lehmann, R., additional, Mann, L., additional, Maselli, A., additional, Menken, G., additional, Mikes, K., additional, Mortan, H., additional, Nasser, N., additional, Nicolaus, D., additional, Plauskat, A., additional, Pomper, L., additional, Quietzsch, A., additional, Ravenhorst, C., additional, Reichelt, C., additional, Reimer, C., additional, Schaefer, B., additional, Scharrer, S., additional, Schirmer, K., additional, Schmidt, K., additional, Schoene, R., additional, Schulze, J., additional, Schuppe, M., additional, Simon, S., additional, Sommer, S., additional, Spranger, K., additional, Talkenberger, A., additional, Tauber, K., additional, Tetlak, A., additional, Toennishoff, T., additional, Voelkel‐Babyesiza, R., additional, Voigts, B., additional, Weiser, U., additional, Wesendorf, S., additional, Wildenauer, S., additional, Wolf, T., additional, Wurziger, J., additional, Zak, J., additional, Zauzig, H.‐D., additional, Ziefle, S., additional, Zincke, S., additional, Vangel, S., additional, Szalai, G., additional, Merkely, B., additional, Kancz, S., additional, Boda, Z., additional, Nagy, A., additional, Laszlo, Z., additional, Matoltsy, A., additional, Gaszner, B., additional, Polgar, P., additional, Habon, T., additional, Noori, E., additional, Juhasz, G., additional, Kanakaridisz, N., additional, Szentpeteri, I., additional, Juhasz, F., additional, Vertes, A., additional, Papp, A., additional, May, Z., additional, Ferenczi, J., additional, Egyutt, M., additional, Kis, E., additional, Engelthaler, G., additional, Szantai, G., additional, Fulop, E., additional, Gombos, P., additional, Gulyas, D., additional, Jen, P., additional, Kiralyhazine Gyorke, E., additional, Kovacs, M., additional, Kovacsne Levang, S., additional, Marianna, S., additional, Radics, Z., additional, Sydó, N., additional, Szalo, R., additional, Szilagyi, A., additional, Sztanyik, F., additional, Vandrus, B., additional, Rangel, G., additional, Bosman, F., additional, Bosschaert, M., additional, Bruin, S., additional, Danse, I., additional, De Graaf, J., additional, de Graauw, J., additional, Debordes, M., additional, Dols, S., additional, Geerlings, F., additional, Gorrebeeck, K., additional, Jerzewski, A., additional, Jetten, W., additional, Kelderman, M., additional, Kloosterman, T., additional, Koomen, E. M., additional, Krikken, J., additional, Melman, P., additional, Mulder, R., additional, Pronk, A., additional, Stallinga‐de Vos, A., additional, te Kaat, J., additional, Tonino, P., additional, Uppelschoten, B., additional, van de Loo, R., additional, van der Kley, T., additional, van Leeuwen, G., additional, van Putten, J. J., additional, Westerman, L., additional, Berge, E., additional, Sirnes, P. A., additional, Gjertsen, E., additional, Hole, T., additional, Erga, K., additional, Hallaråker, A., additional, Skjelvan, G., additional, Østrem, A., additional, Ghezai, B., additional, Svilaas, A., additional, Christersson, P., additional, Øien, T., additional, Høegh Henrichsen, S., additional, Berg‐Johansen, J., additional, Otterstad, J. E., additional, Antonsen, H., additional, Ausen, K., additional, Claussen, H., additional, Dominguez, I., additional, Jekthammer, A., additional, Lensebraaten, A. B., additional, Nilsen, V., additional, O'Donovan, M., additional, Ringdalen, K., additional, Strand, S., additional, Korzeniak, R., additional, Gieroba, A., additional, Biedrzycka, M., additional, Ogorek, M. (Marcin), additional, Wozakowska‐Kaplon, B., additional, Loboz‐Grudzien, K., additional, Kosior, J., additional, Supinski, W., additional, Kuzniar, J., additional, Zaluska, R., additional, Hiczkiewicz, J., additional, Swiatkowska‐Byczynska, L., additional, Kucharski, L., additional, Gruchala, M., additional, Minc, P., additional, Olszewski, M., additional, Kania, G., additional, Krzciuk, M., additional, Lajkowski, Z., additional, Ostrowska‐Pomian, B., additional, Lewczuk, J., additional, Zinka, E., additional, Karczmarczyk, A., additional, Chmielnicka‐Pruszczynska, M., additional, Trusz‐Gluza, M., additional, Opolski, G., additional, Bronisz, M., additional, Ogorek, M. (Michal), additional, Glanowska, G., additional, Ruszkowski, P., additional, Jaworska, K., additional, Sciborski, R., additional, Okopien, B., additional, Kukla, P., additional, Wozniak‐Skowerska, I., additional, Galbas, K., additional, Cymerman, K., additional, Jurowiecki, J., additional, Miekus, P., additional, Myszka, W., additional, Mazur, S., additional, Lysek, R., additional, Baszak, J., additional, Rusicka‐Piekarz, T., additional, Raczak, G., additional, Domanska, E., additional, Nessler, J., additional, Lesnik, J., additional, Ambicka, M., additional, Andrzejewski, D., additional, Araminowicz, J., additional, Barszcz, A., additional, Bartkowiak, R., additional, Bartnik, J., additional, Basiak, M., additional, Bekieszczuk, E., additional, Bernat, L., additional, Biedrzycki, L., additional, Biernacka, A., additional, Blaszczyk, D., additional, Broton, E., additional, Brzozowski, W., additional, Brzustowska, M., additional, Bzymek, R., additional, Chmielowski, A., additional, Chojnowski, P., additional, Cichomski, R., additional, Cieslak, K., additional, Cieszynska, A., additional, Curyllo, B., additional, Czamara, M., additional, Danilowicz‐Szymanowicz, L., additional, Dolecka, B., additional, Drelich, L., additional, Dudzik‐Richter, B., additional, Dybala, T., additional, Dziuba, M., additional, Faron, W., additional, Figura‐Chmielewska, M., additional, Frankiewicz, A., additional, Gadzinski, W., additional, Gasior, E., additional, Gosciniecka, B., additional, Gutknecht, P., additional, Guziewicz, M., additional, Jackun‐Podlesna, A., additional, Jaguszewska, G., additional, Jankielewicz, J., additional, Jaremczuk‐Kaczmarczyk, A., additional, Jargiello‐Baszak, M., additional, Jarzebowski, A., additional, Jaskulska‐Niedziela, E., additional, Jaworska‐Drozdowska, M., additional, Kabat, J., additional, Kaczmarzyk‐Radka, A., additional, Kalin, K., additional, Kaliszczak, R., additional, Kiliszek, M., additional, Klata, M., additional, Kluczewski, M., additional, and Kobielusz‐Gembala, I., additional more...
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- 2019
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18. Pro: Moderate alcohol use is beneficial in nonalcoholic steatohepatitis
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McHenry, Scott, primary, Alghamdi, Saad, additional, and Lisker-Melman, Mauricio, additional
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- 2018
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19. Response to Letter Regarding Article, 'Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study'
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Yonathan F. Melman, Junjie Xiao, Zachary R Lavender, Ranendra K. Das, Quynh A. Truong, Bridget Simonson, Kirsty Danielson, David A. Kass, Ravi V. Shah, André G. Kléber, Khalid Chakir, Saumya Das, Jagmeet P. Singh, Yaoyu E. Wang, Gregory D. Lewis, Anthony Rosenzweig, and Andreas S. Barth more...
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Male ,0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Apoptosis ,030204 cardiovascular system & hematology ,Cardiac Resynchronization Therapy ,Translational Research, Biomedical ,03 medical and health sciences ,0302 clinical medicine ,Physiology (medical) ,Internal medicine ,microRNA ,medicine ,Animals ,Humans ,Myocyte ,Myocytes, Cardiac ,Heart Failure ,business.industry ,medicine.disease ,Cardiovascular physiology ,MicroRNAs ,Circulating MicroRNA ,030104 developmental biology ,Heart failure ,Cardiology ,Female ,Tumor necrosis factor alpha ,Cardiology and Cardiovascular Medicine ,business ,Extracellular RNA - Abstract
We thank Sardu and colleagues for their comments. Our report demonstrates that baseline levels of microRNA-30d (miR-30d) are correlated with response to cardiac resynchronization therapy and that miR-30d was dynamically regulated by mechanical stress.1 Moreover, miR-30d appeared to be an adaptive response and was cardioprotective against tumor necrosis factor-α–mediated apoptosis. Similar to our study, Marfella et al2 noted differential expression of several plasma miRNAs in cardiac resynchronization therapy responders versus nonresponders 1 year after cardiac resynchronization therapy. The lack of significant overlap between the sets of extracellular miRNAs reflects some of the ongoing issues in extracellular RNA research. The first issue is differences in patient populations and small sample sizes. The second is variances in methodology. Several groups, including … more...
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- 2016
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20. Endoscopic versus Histopathologic Agreement in the Diagnosis of Gastric Antral Vascular Ectasia
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Mauricio Lisker-Melman, Pierre Blais, Jeremy Louissaint, and Chien-Huan Chen
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medicine.medical_specialty ,Hepatology ,business.industry ,Internal medicine ,Gastroenterology ,Medicine ,Gastric antral vascular ectasia ,business ,medicine.disease - Published
- 2017
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21. Immune response to extracellular matrix collagen in chronic hepatitis C-induced liver fibrosis
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Mauricio Lisker-Melman, Haseeb Ilias Basha, Kevin M. Korenblat, Christopher D. Anderson, Thalachallour Mohanakumar, William C. Chapman, Brian B. Borg, Jeffrey S. Crippin, Anil B. Seetharam, Surendra Shenoy, and Vijay Subramanian more...
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_treatment ,Hepatitis C virus ,Enzyme-Linked Immunosorbent Assay ,Vimentin ,Liver transplantation ,medicine.disease_cause ,Polymerase Chain Reaction ,Article ,Cohort Studies ,Immune system ,Fibrosis ,medicine ,Humans ,Aged ,Transplantation ,Hepatology ,biology ,business.industry ,Hepatitis C ,Middle Aged ,medicine.disease ,Extracellular Matrix ,surgical procedures, operative ,Cytokine ,Gene Expression Regulation ,Immune System ,Chronic Disease ,Immunology ,biology.protein ,Cytokines ,RNA, Viral ,Female ,Surgery ,Collagen ,Antibody ,business - Abstract
Hepatitis C virus (HCV) infection and its recurrence after orthotopic liver transplantation (OLT) are associated with the remodeling of extracellular matrix (ECM) components [particularly collagen (Col)], which leads to fibrosis. Our aim was to determine whether the development of antibodies (Abs) to self-antigen Col in HCV-infected patients correlates with the fibrosis stage and the peripheral cytokine response. Patients with chronic HCV infection, patients with HCV recurrence after OLT who had undergone a biopsy procedure, and healthy control subjects were enrolled. The HCV subjects (n = 70) were stratified as follows: (1) a non-OLT group without fibrosis (Scheuer stages 0-2), (2) a non-OLT group with fibrosis (Scheuer stages 3-4), (3) a post-OLT group without fibrosis (Scheuer stages 0-2), and (4) a post-OLT group with fibrosis (Scheuer stages 3-4). Serum samples were analyzed for Abs against Col1, Col2, Col4, Col5, and vimentin with enzyme-linked immunosorbent assays. Serum levels of cytokines were measured with multiplex bead immunoassays. The levels of Abs to Col1 were higher in the fibrosis groups versus the no-fibrosis groups and the controls for both non-OLT patients (P < 0.001) and post-OLT patients (P = 0.01). There were increased levels of Abs to Col2, Col4, Col5, and vimentin in the non-OLT fibrosis group (Col2, P = 0.0001; Col4, P = 0.122; Col5, P < 0.0001; vimentin, P = 0.36) and in the post-OLT fibrosis group (Col2, P = 0.006; Col4, P = 0.19; Col5, P < 0.0001; vimentin, P = 0.24) in comparison with the no-fibrosis groups. The non-OLT and post-OLT fibrosis groups demonstrated significantly higher T helper 2 (T(h) 2) and T helper 17 (T(h) 17) cytokine levels and lower T helper 1 cytokine levels in comparison with the no-fibrosis groups. Our results demonstrate that in HCV-infected patients, the levels of Abs to ECM Col1, Col2, and Col5 positively correlate with liver fibrosis, which is associated with a predominantly T(h) 2 and T(h) 17 cytokine profile. more...
- Published
- 2011
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22. Peginterferon α-2a Plus Ribavirin in Latino and Non-Latino Whites With HCV Genotype 1: Histologic Outcomes and Tolerability From the LATINO Study
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Fayez M. Hamzeh, Ambrose Kwok, Ellen Lentz, Mauricio Lisker-Melman, Luis A. Balart, and Maribel Rodriguez-Torres
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Adult ,Liver Cirrhosis ,Male ,Oncology ,medicine.medical_specialty ,Adolescent ,Genotype ,Hepacivirus ,Interferon alpha-2 ,Antiviral Agents ,Polyethylene Glycols ,chemistry.chemical_compound ,Internal medicine ,Ribavirin ,medicine ,Humans ,Prospective Studies ,Adverse effect ,Prospective cohort study ,Aged ,Hepatology ,business.industry ,Gastroenterology ,Interferon-alpha ,virus diseases ,Hispanic or Latino ,Hepatitis C ,Middle Aged ,medicine.disease ,Recombinant Proteins ,digestive system diseases ,Liver ,Tolerability ,chemistry ,Immunology ,Female ,business ,Body mass index ,Peginterferon alfa-2a ,medicine.drug - Abstract
We sought to compare the histologic response, safety, and tolerability in Latino and non-Latino patients with hepatitis C virus (HCV) genotype 1 treated with peginterferon α-2a plus ribavirin (LATINO study).LATINO was a prospective, open-label, multicenter study that enrolled 269 Latinos and 300 non-Latinos receiving peginterferon α-2a 180 μg/week and ribavirin 1,000/1,200 mg/day for 48 weeks. Liver biopsies were obtained within 18 months of baseline and at week 72. Improved or worsened liver fibrosis and necroinflammatory activity were assessed by the Ishak-modified histologic activity index scoring system. Efficacy and safety parameters were monitored during treatment and the 24-week follow-up period.The primary study results published elsewhere showed a higher sustained virologic response (SVR) rate among non-Latinos than Latinos (49% vs. 34%; P0.001). Paired biopsy data were available for 157 Latinos and 201 non-Latinos. At baseline, more Latinos vs. non-Latinos had alanine aminotransferase (ALT)3 × the upper limit of normal (20% vs. 18%) and cirrhosis (13% vs. 10%). Both groups experienced improvement in Ishak activity at week 72, although the improvement rates were higher in non-Latinos than Latinos (59% vs. 47%; P=0.03). For both groups, more patients with SVR compared with non-responders had improved Ishak fibrosis scores. In both groups, baseline Ishak activity score (P0.0001 for both) was predictive of Ishak activity response. Additional predictors in Latinos were age (P=0.0023), body mass index (BMI) (P=0.068), baseline ALT quotient (P=0.031), and baseline Ishak fibrosis scores (P=0.021). There were no significant differences in steatosis changes between the two groups. Adverse events (AEs) and withdrawals due to AEs were more frequent in non-Latinos.Significant proportions of patients in both groups had histologic response to peginterferon α-2a plus ribavirin. However, histologic response was higher in non-Latinos than in Latinos regardless of virologic response. This study highlights the need for additional strategies to improve virologic response in Latinos. more...
- Published
- 2010
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23. Transcription of G-Protein Coupled Receptors in Corporeal Smooth Muscle is Regulated by the Endogenous Neutral Endopeptidase Inhibitor Sialorphin
- Author
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Kelvin P. Davies, Yuehong Tong, Arnold Melman, Moses Tar, and Scott I. Tiplitsky
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Male ,G protein ,Urology ,Myocytes, Smooth Muscle ,Down-Regulation ,Biology ,Sensitivity and Specificity ,Article ,Receptors, G-Protein-Coupled ,Random Allocation ,Reference Values ,Gene expression ,Animals ,Myocyte ,Protein Precursors ,Salivary Proteins and Peptides ,education ,Receptor ,Cells, Cultured ,Probability ,G protein-coupled receptor ,Regulation of gene expression ,education.field_of_study ,Reverse Transcriptase Polymerase Chain Reaction ,Penile Erection ,Angiotensin II receptor type 2 ,Rats, Inbred F344 ,Rats ,Cell biology ,Disease Models, Animal ,Gene Expression Regulation ,Biochemistry ,Neprilysin ,Signal transduction - Abstract
Several reports suggest that the rat Vcsa1 gene is down-regulated in models of erectile dysfunction. The Vcsa protein product sialorphin is an endogenous neutral endopeptidase inhibitor and its down-regulation could result in prolonged activation of G-protein activated signaling pathways by their peptide agonists. We investigated whether Vcsa1 down-regulation could result in an adaptive change in GPCR (G-protein coupled receptor) expression.Gene expression in cultured rat corporeal smooth muscle cells following treatment with siRNA directed against Vcsa1 or the neutral endopeptidase gene was analyzed using microarray and quantitative reverse transcriptase-polymerase chain reaction. In rats Vcsa1 is one of the most down-regulated genes following bilateral transection of the cavernous nerves. In that animal model we also investigated whether Vcsa1 down-regulation was accompanied by similar changes in gene expression in corporeal smooth muscle cells in which Vcsa1 was knocked down in vitro.Microarray analysis and quantitative reverse transcriptase-polymerase chain reaction demonstrated that corporeal smooth muscle cells treated in vitro with siRNA against Vcsa1 resulted in GPCR up-regulation as a functional group. In contrast, treatment of corporeal smooth muscle cells that lowered neutral endopeptidase activity resulted in decreased GPCR expression. These results suggest that the peptide product of Vcsa1, sialorphin, can effect GPCR expression by acting on neutral endopeptidase. In animals with bilaterally transected cavernous nerves the decreased Vcsa1 expression is accompanied by increased GPCR expression in cavernous tissue.These experiments suggest that the mechanism by which Vcsa1 modulates erectile function is partly mediated through changes in GPCR expression. more...
- Published
- 2008
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24. Endoscopic versus Histopathologic Agreement in the Diagnosis of Gastric Antral Vascular Ectasia
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Louissaint, Jeremy, primary, Blais, Pierre, additional, Chen, Chien-Huan, additional, and Lisker-Melman, Mauricio, additional
- Published
- 2017
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25. The Effects of a Genital Vibratory Stimulation Device on Sexual Function and Genital Sensation
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Guess, Marsha K., primary, Connell, Kathleen A., additional, Chudnoff, Scott, additional, Adekoya, Olusola, additional, Richmond, Cherrilyn, additional, Nixon, Kayla E., additional, Freeman, Katherine, additional, and Melman, Arnold, additional more...
- Published
- 2017
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26. An effectiveness study of group psychoeducation for hepatitis C patients in community clinics
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North, Carol S., primary, Pollio, David E., additional, Sims, Omar T., additional, Jain, Mamta K., additional, Brown, Geri R., additional, Downs, Dana L., additional, Lisker-Melman, Mauricio, additional, and Hong, Barry A., additional more...
- Published
- 2017
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27. Elevated Soluble CD30 Characterizes Patients With Hepatitis C Virus-Induced Liver Allograft Cirrhosis
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William C. Chapman, Ankit Bharat, Thalachallour Mohanakumar, Mauricio Lisker-Melman, Surendra Shenoy, Jeffrey A. Lowell, Anjali Golocheikine, Nancy Steward, Jeffrey S. Crippin, and Kishore Narayanan
- Subjects
Adult ,Liver Cirrhosis ,Male ,Cirrhosis ,Hepacivirus ,medicine.medical_treatment ,Hepatitis C virus ,Ki-1 Antigen ,Liver transplantation ,medicine.disease_cause ,Virus ,Interferon-gamma ,Postoperative Complications ,Antigens, CD ,Interferon ,medicine ,Humans ,Transplantation, Homologous ,Aged ,Transplantation ,biology ,business.industry ,Interleukin ,Middle Aged ,medicine.disease ,biology.organism_classification ,Hepatitis C ,Liver Transplantation ,surgical procedures, operative ,Immunology ,Female ,business ,Biomarkers ,medicine.drug - Abstract
Hepatitis C virus (HCV) recurrence after orthotopic liver transplantation (OLT) significantly accelerates progression to allograft cirrhosis. Current biochemical parameters to monitor progression of chronic HCV after OLT have yielded low specificity and sensitivity. Here we investigated the HCV-specific immunity and serum levels of soluble CD30 (sCD30), a novel marker of Th2 immunity, in patients with and without allograft cirrhosis. Patients with hepatic inflammation but no cirrhosis (HIN, n=20) revealed elevated serum interferon (IFN)-γ and high frequency of IFN-y producing CD4 + T(h1) cells compared to those with hepatic cirrhosis (HFC, n=20) that had high interleukin (IL)-5 and IL-5 producing CD4 + T(h2) cells. Patients with HFC, but not HIN, were found to have significantly higher levels of sCD30. Therefore, we conclude that lack of optimal Th1-type CD4 + T cells is associated with HCV-induced allograft cirrhosis. Further, sCD30 may represent a novel marker for surveillance of hepatic cirrhosis in transplant recipients with chronic HCV infection. more...
- Published
- 2007
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28. MP8-13 PLASMID-BASED CELL-SPECIFIC GENE TRANSFER TO TREAT OVERACTIVE BLADDER SYNDROME
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Arnold Melman, Aryeh Keehn, Kelvin P. Davies, Sylvia O. Suadicani, and Moses Tar
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Cell specific ,medicine.medical_specialty ,Plasmid ,business.industry ,Urology ,medicine ,Cancer research ,Gene transfer ,business ,Overactive bladder syndrome - Published
- 2015
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29. No evidence for association between NOTCH4 and schizophrenia in a large family-based and case–control association analysis
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Johannes Schumacher, Peter Propping, Rachel Bachner-Melman, Thomas G. Schulze, Roland Ivo, Wolfgang Maier, Ilana Kremer, Daniel J. Müller, M. Dobrusin, Marcella Rietschel, Mustafa Mujaheed, Markus M. Nöthen, Alon Reshef, Isaam Bannoura, Monika Blanaru, Kristina Kesper, Sven Cichon, Robert H. Belmaker, Richard P. Ebstein, and I. Murad more...
- Subjects
Genetics ,education.field_of_study ,Receptors, Notch ,Haplotype ,Population ,Single-nucleotide polymorphism ,Locus (genetics) ,Biology ,Polymorphism, Single Nucleotide ,language.human_language ,German ,Psychiatry and Mental health ,Case-Control Studies ,Proto-Oncogene Proteins ,Schizophrenia ,Genetic predisposition ,language ,Humans ,Population study ,Receptor, Notch4 ,education ,Biological Psychiatry ,Genetics (clinical) ,Genetic association - Abstract
Objectives An analysis of 80 British parent–offspring trios by Wei and Hemmings in 2000 revealed thre1e out of five markers within the NOTCH4 locus to be strongly associated with schizophrenia. In our present study, we have examined NOTCH4 markers in large samples of German and Palestinian-Arab origin. Methods Our study population comprised a German case–control sample (n=512 schizophrenia patients and n=232 controls) and two independent parent–offspring trio samples of German (n=159 trios) and Palestinian-Arab (n=208 trios) descent. We examined a total of ten single nucleotide polymorphisms within the NOTCH4 locus and the adjacent loci, spanning a region of approximately 100 kb. Results Neither single marker nor haplotype analyses showed association with schizophrenia. In addition, analyses of the German case–control and trio samples revealed no significant association between NOTCH4 polymorphisms and early-onset schizophrenia. Conclusions Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population. more...
- Published
- 2006
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30. How Anorexic-like Are the Symptom and Personality Profiles of Aesthetic Athletes?
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Rachel Bachner-Melman, Ada H. Zohar, Yoel Elizur, Richard P. Ebstein, and Naama Constantini
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Adult ,medicine.medical_specialty ,Adolescent ,Personality Inventory ,media_common.quotation_subject ,Physical Therapy, Sports Therapy and Rehabilitation ,Anorexia nervosa ,medicine.disease_cause ,Eating disorder not otherwise specified ,Body Image ,Prevalence ,medicine ,Humans ,Personality ,Orthopedics and Sports Medicine ,Israel ,Psychiatry ,media_common ,Analysis of Variance ,Chi-Square Distribution ,biology ,Athletes ,Perfectionism (psychology) ,medicine.disease ,biology.organism_classification ,Anorexia ,Eating disorders ,Harm avoidance ,Female ,medicine.symptom ,Psychology ,Sports ,Dieting - Abstract
BACHNER-MELMAN R., A. H. ZOHAR, R. P. EBSTEIN, Y. ELIZUR, and N. CONSTANTINI. How Anorexic-like Are the Symptom and Personality Profiles of Aesthetic Athletes? Med. Sci. Sports Exerc.,Vol. 38, No. 4, pp. 628–636, 2006. Purpose: We tested the hypothesis that aesthetic athletes (AA) have anorexic-like eating attitudes and behaviors, share personality characteristics such as perfectionism and obsessiveness, and are at high risk of eating disorders. Methods: We compared symptomatology, personality variables typical of anorexia nervosa, and lifetime eating disorder prevalence across four groups of Israeli women: 31 anorexics, 111 AA (mostly dancers), 68 nonaesthetic athletes (NAA), and 248 controls. All participants completed self-report measures of symptomatology, harm avoidance, perfectionism, obsessiveness, self-esteem, and self-rated facial attractiveness and were screened for eating disorders. Those screening positively were interviewed and diagnosed using the structured clinical interview for DSM-IV. Results: Scores of the anorexic women differed from those of the three other groups in the expected direction on all variables. NAA scored similarly to controls, but had greater body satisfaction and less drive for thinness. Surprisingly, the AA did not differ from control women on any self-report measure. However, significantly more AA (11.7%) than NAA (5.8%) and controls (4.4%) had a lifetime diagnosis of eating disorder not otherwise specified (EDNOS). The eating attitudes and behavior of the 13 AA with a lifetime history of EDNOS fell intermediately between the anorexic women and the controls, whereas their personality profile resembled that of controls. Conclusions: Being a nonaesthetic female athlete in Israel appears to promote body esteem and offer some protection from a preoccupation with dieting. AA also appear to enjoy excellent psychological health; however, a subgroup has EDNOS and appears not to receive appropriate treatment for it. These results lend credibility to the existence of the diagnostic entity of anorexia athletica, proposed to be a subclinical, environmentally influenced eating disorder with a favorable prognosis. more...
- Published
- 2006
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31. Disseminated histoplasmosis in a liver transplant recipient
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Kevin M. Korenblat, Mauricio Lisker-Melman, Gary R. Zuckerman, Jeffrey S. Crippin, and Young S. Oh
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Male ,Reoperation ,medicine.medical_specialty ,Antifungal Agents ,Itraconazole ,medicine.medical_treatment ,Cholangitis, Sclerosing ,Liver transplantation ,Gastroenterology ,Histoplasmosis ,Pericarditis ,Postoperative Complications ,Amphotericin B ,Internal medicine ,medicine ,Humans ,Transplantation ,Hepatology ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,digestive system diseases ,Liver Transplantation ,Endoscopy ,Surgery ,Pleural Effusion ,Liver transplant recipient ,Diarrhea ,Treatment Outcome ,medicine.symptom ,business ,medicine.drug - Abstract
A 61-yr-old liver transplant recipient presented with abdominal cramping and nonbloody diarrhea resulting in orthostasis. Multiple ulcerations throughout the colon were seen during endoscopy, and biopsies from the ulcer edges revealed histoplasmosis. Treatment with a course of itraconazole improved the diarrhea. The patient later presented with pericarditis and symptomatic pleural effusions, the latter of which was confirmed to be a result of disseminated histoplasmosis. Treatment with amphotericin B led to resolution. Histoplasmosis should be considered in liver transplant patients with diarrhea and large ulcers in the colon. The presence of disseminated histoplasmosis should be ruled out once colonic histoplasmosis has been diagnosed. more...
- Published
- 2006
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32. Critical Surgical Techniques for Radical Perineal Prostatectomy
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Albert C. Leung, Judd Boczko, Johanna C. Figueroa, and Arnold Melman
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Male ,Prostatectomy ,Biochemical recurrence ,medicine.medical_specialty ,Surgical approach ,business.industry ,Urology ,medicine.medical_treatment ,Perineal approach ,Equipment Design ,Perineum ,Surgery ,medicine.anatomical_structure ,medicine ,Humans ,Positive Surgical Margin ,business ,Radical perineal prostatectomy ,Radical retropubic prostatectomy - Abstract
Radical perineal prostatectomy was historically the surgical treatment of choice for localized adenocarcinoma of the prostate until the 1980s when radical retropubic prostatectomy began to gain popularity. Nevertheless, the perineal approach possesses advantages that prompt resurgence in the interest of this classic operation. We review the relevant anatomy and our modified technique of performing a successful radical perineal prostatectomy.The English literature pertaining to the different surgical approaches to radical perineal prostatectomy was reviewed through PubMed. Attention was paid to its indications, anatomical significance and various surgical techniques.Studies demonstrate no difference in the incidence of positive surgical margins and biochemical recurrence between radical retropubic and perineal prostatectomies. Furthermore, the perineal approach avoids the dorsal venous complex and better facilitates the vesicourethral anastomosis in the face of minimal pain and requirement for transfusion. We use a modified Belt approach, aiming to yield the most optimal outcome with minimal morbidity. A meticulous anatomical approach is warranted if complications such as rectal injury, incontinence and erectile dysfunction are to be minimized.With careful preoperative evaluation, selected patients should benefit from radical perineal prostatectomy for the management of localized prostate cancer. Familiarity with this specialized technique should be an immeasurable addition to any armamentarium in the therapy of prostatic diseases. more...
- Published
- 2004
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33. Quantitative Somatosensory Testing of the Penis: Optimizing the Clinical Neurological Examination
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Haftan Eckholdt, Arnold Melman, Joseph C. Arezzo, and Clifford B. Bleustein
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Male ,medicine.medical_specialty ,Somatosensory testing ,Urology ,Neurological examination ,Sensitivity and Specificity ,Vibration ,Diabetes Complications ,Foreskin ,Erectile Dysfunction ,Surveys and Questionnaires ,Sensory threshold ,Pressure ,medicine ,Humans ,Neurologic Examination ,Analysis of Variance ,medicine.diagnostic_test ,business.industry ,Penile Erection ,Temperature ,Glans penis ,Middle Aged ,medicine.disease ,Surgery ,Logistic Models ,medicine.anatomical_structure ,Erectile dysfunction ,Touch ,Sensory Thresholds ,Hypertension ,Etiology ,business ,Penis - Abstract
Quantitative somatosensory testing, including vibration, pressure, spatial perception and thermal thresholds of the penis, has demonstrated neuropathy in patients with a history of erectile dysfunction of all etiologies. We evaluated which measurement of neurological function of the penis was best at predicting erectile dysfunction and examined the impact of location on the penis for quantitative somatosensory testing measurements.A total of 107 patients were evaluated. All patients were required to complete the erectile function domain of the International Index of Erectile Function (IIEF) questionnaire, of whom 24 had no complaints of erectile dysfunction and scored within the "normal" range on the IIEF. Patients were subsequently tested on ventral middle penile shaft, proximal dorsal midline penile shaft and glans penis (with foreskin retracted) for vibration, pressure, spatial perception, and warm and cold thermal thresholds.Mixed models repeated measures analysis of variance controlling for age, diabetes and hypertension revealed that method of measurement (quantitative somatosensory testing) was predictive of IIEF score (F = 209, df = 4,1315, p0.001), while site of measurement on the penis was not. To determine the best method of measurement, we used hierarchical regression, which revealed that warm temperature was the best predictor of erectile dysfunction with pseudo R(2) = 0.19, p0.0007. There was no significant improvement in predicting erectile dysfunction when another test was added. Using 37C and greater as the warm thermal threshold yielded a sensitivity of 88.5%, specificity 70.0% and positive predictive value 85.5%.Quantitative somatosensory testing using warm thermal threshold measurements taken at the glans penis can be used alone to assess the neurological status of the penis. Warm thermal thresholds alone offer a quick, noninvasive accurate method of evaluating penile neuropathy in an office setting. more...
- Published
- 2003
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34. The Effect of Ovariectomy and Long-term Estrogen Replacement on Bladder Structure and Function in the Rat
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Nicole Fleischmann, Arnold Melman, George J. Christ, and Theresa Sclafani
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medicine.medical_specialty ,medicine.drug_class ,Ovariectomy ,Urology ,media_common.quotation_subject ,Urinary system ,Urinary Bladder ,Urinary incontinence ,Gömöri trichrome stain ,Urination ,Rats, Sprague-Dawley ,Internal medicine ,medicine ,Animals ,media_common ,Urinary bladder ,medicine.diagnostic_test ,business.industry ,Estrogen Replacement Therapy ,Cystometry ,Estrogens ,Muscle, Smooth ,medicine.disease ,Rats ,Menopause ,Urodynamics ,medicine.anatomical_structure ,Endocrinology ,Connective Tissue ,Estrogen ,Female ,medicine.symptom ,business - Abstract
PURPOSE The use of estrogen replacement therapy for treating postmenopausal urinary incontinence is a controversial topic. We examined the behavioral, cystometric and histological changes that occur with long-term estrogen depletion and supplementation in rat bladders to determine the role of menopause in lower urinary tract dysfunction. MATERIALS AND METHODS A total of 40 female Sprague-Dawley rats were placed into 1 of 3 groups, including bilateral ovariectomy, bilateral ovariectomy plus estrogen replacement and control. The estrogen replaced group received a 0.25 mg. 16-week sustained release pellet (Innovative Research of America, Sanasota, Florida) placed subcutaneously. After surgery voiding frequency and volume were measured in 24-hour periods by placing animals in metabolic cages. After 16 weeks the rats underwent catheterization and continuous cystometry. The bladder was then removed and stained with Gomori trichrome. The collagen-to-smooth muscle density ratio was calculated for each specimen using current imaging software. RESULTS There was no significant difference in voiding patterns in the 3 groups, as measured by volume and voiding frequency. Cystometric data showed a trend toward higher voiding pressure, threshold pressure, baseline pressure and mean inter-voiding pressure in the ovariectomy group compared with the estrogen and control groups, although there was no statistical significance. Histological studies showed a higher mean collagen-to-smooth muscle ratio plus or minus standard deviation in the ovariectomy group (0.807 +/- 0.204) than in the ovariectomy plus estrogen replacement (0.709 +/- 0.118) and control (0.700 +/- 0.129) groups (p0.05). Furthermore, when histological and cystometric data were compared for individual samples, we found a direct correlation of mean inter-voiding pressure (a measure of bladder instability) with the collagen-to-smooth muscle ratio (p0.05). CONCLUSIONS Long-term estrogen replacement is beneficial for treating postmenopausal urinary incontinence. more...
- Published
- 2002
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35. MP1-11 DIABETES ATTENUATES UROTHELIAL MODULATION OF BLADDER TONE
- Author
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Kelvin P. Davies, Moses Tar, Arnold Melman, Yi Wang, and Shibo Fu
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medicine.medical_specialty ,business.industry ,Modulation ,Urology ,Diabetes mellitus ,Medicine ,Bladder tone ,business ,medicine.disease - Published
- 2014
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36. MP43-04 OPIORPHIN IS A MASTER REGULATOR OF GENE EXPRESSION LEADING TO PRIAPISM ASSOCIATED WITH SICKLE CELL DISEASE
- Author
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Kelvin P. Davies, Arnold Melman, Shibo Fu, Yi Wang, and Moses Tar
- Subjects
business.industry ,Urology ,Priapism ,Opiorphin ,Cell ,Master regulator ,Disease ,medicine.disease ,Bioinformatics ,medicine.anatomical_structure ,Gene expression ,medicine ,business ,medicine.drug - Published
- 2014
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37. SUPPRESSION OF RENAL INFLAMMATION WITH VITAMINS A AND E IN ASCENDING PYELONEPHRITIS IN RATS
- Author
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Israel Franco, Richard J. Mazzaccaro, Arnold Melman, Neeru Chopra, and Robert T. Bennett
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Vitamin ,medicine.medical_specialty ,Antioxidant ,medicine.drug_class ,business.industry ,Urology ,Vitamin E ,medicine.medical_treatment ,Antibiotics ,Case-control study ,Inflammation ,medicine.disease ,Gastroenterology ,Regimen ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,medicine ,medicine.symptom ,business ,Kidney disease - Abstract
Purpose: We evaluated the effects of vitamin A and E supplementation alone or in combination with non-steroidal anti-inflammatory drugs (NSAIDs) on the development of inflammation in an animal model of ascending pyelonephritis.Materials and Methods: Ascending pyelonephritis was induced in adult rats by surgical bladder inoculation with P-pili-forming Escherichia coli. Treatment of pyelonephritic rats was initiated at 72 hours post-infection. Treatment groups included no treatment, or a five day regimen of antibiotic only, antibiotic plus vitamins A and E, or antibiotic, vitamins and either of two NSAIDs. Kidneys were harvested at six weeks post-infection and assessed for histopathologic inflammation.Results: Antibiotic treatment of pyelonephritic rats with vitamins A and E alone or in combination with NSAIDs resulted in significantly less kidney inflammation, as compared with untreated rats or rats treated with antibiotic alone. There was no significant difference in inflammation between animals t... more...
- Published
- 1999
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38. THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION
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Arnold Melman and J. Clive Gingell
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Smooth muscle relaxation ,medicine.medical_specialty ,business.industry ,Urology ,medicine.disease ,Bioinformatics ,Pathophysiology ,chemistry.chemical_compound ,Endocrinology ,Erectile dysfunction ,Quality of life ,Cigarette smoking ,chemistry ,Internal medicine ,Epidemiology ,medicine ,Risk factor ,business ,Cyclic guanosine monophosphate - Abstract
Purpose: Published studies on the epidemiology of erectile dysfunction and the physiology/pathophysiology of erectile function are reviewed.Materials and Methods: A literature search of more than 400 studies of the epidemiology and pathophysiology of impotence and erectile dysfunction published during the last 3 decades was conducted and the most pertinent articles are discussed.Results: It has been estimated that the prevalence of erectile dysfunction of all degrees is 52% in men 40 to 70 years old, with higher rates in those older than 70 years. Erectile dysfunction has a significant negative impact on quality of life. Risk factors for erectile dysfunction include aging, chronic illnesses, various medications and cigarette smoking. A nitric oxide/cyclic guanosine monophosphate mechanism has an important role in mediating the corporal smooth muscle relaxation necessary for erectile function. Other mechanisms involving neuropeptides, gap junctions and ion channels also may modulate corporal smooth... more...
- Published
- 1999
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39. FORMATION OF NEOCLITORIS FROM GLANS PENIS BY REDUCTION GLANSPLASTY WITH PRESERVATION OF NEUROVASCULAR BUNDLE IN MALE-TO-FEMALE GENDER SURGERY: FUNCTIONAL AND COSMETIC OUTCOME
- Author
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Arnold Melman and Jamil Rehman
- Subjects
Adult ,Male ,medicine.medical_specialty ,business.industry ,Urology ,Glans penis ,Clitoris ,Middle Aged ,Neurovascular bundle ,Introitus ,Surgery ,Clitoral hood ,Gender reassignment surgery ,medicine.anatomical_structure ,Patient Satisfaction ,Vagina ,medicine ,Humans ,Female ,Sex ,Glans ,business ,Transsexualism ,Penis - Abstract
During male-to-female gender reassignment surgery we used an abdominal pedicled inverted penile skin technique to create a vagina and extra folds of skin to create a clitoral hood. Although patients had orgasms with that technique, there was a general request for the placement of a sensate, erectile clitoris. Therefore, in 10 such patients undergoing transsexual surgery a neoclitoris was fashioned from the glans penis. Surgical technique and results are described.From 1980 to 1995, 57 male-to-female gender surgeries were performed at our university center. In the last 10 such patients undergoing transsexual surgery a neoclitoris was created. Glans volume is reduced to match that of a normal size clitoris and the entire length of the dorsal neurovascular bundle is preserved. The neoclitoris is placed through a buttonhole in the newly constructed introitus. There was minimal bleeding from the bundle intraoperatively.In 8 of 10 patients the neoclitoris remained intact postoperatively with good sensation to touch, vibration and light pressure (sexual sensation). The cosmetic and functional appearance was that of a normal clitoris, and patients were satisfied. In 2 patients the results were not satisfactory because of necrosis of the neoclitoris.This technique has excellent functional and cosmetic results in the majority of patients. Preservation of the somatic, tactile and vibratory sensation of the neoclitoris is surgically practical, and can afford the patient the possibility of a more functional outcome of gender reassignment surgery. more...
- Published
- 1999
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40. Simplified Spectrographic Display for Bedside Electrographic Seizure Detection in the ICU (P4.200)
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Yan, Peter, primary, Melman, Tamar, additional, and Grinspan, Zachary, additional
- Published
- 2016
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41. Response to Letter Regarding Article, “Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study”
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Melman, Yonathan F., primary, Shah, Ravi, additional, Danielson, Kirsty, additional, Xiao, Junjie, additional, Simonson, Bridget, additional, Barth, Andreas, additional, Chakir, Khalid, additional, Lewis, Gregory D., additional, Lavender, Zachary, additional, Truong, Quynh A., additional, Kleber, Andre, additional, Das, Ranendra, additional, Rosenzweig, Anthony, additional, Wang, Yaoyu, additional, Kass, David A., additional, Singh, Jagmeet P., additional, and Das, Saumya, additional more...
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- 2016
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42. ENDOTHELIN-1 AS A PUTATIVE MODULATOR OF GENE EXPRESSION AND CELLULAR PHYSIOLOGY IN CULTURED HUMAN CORPORAL SMOOTH MUSCLE CELLS
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Scott Serels, Annamaria Giraldi, Michael V. Autieri, Arnold Melman, and George J. Christ
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Adult ,Endothelin Receptor Antagonists ,Male ,Cell physiology ,medicine.medical_specialty ,Urology ,Biology ,Phenylephrine ,Internal medicine ,medicine ,Humans ,RNA, Messenger ,Northern blot ,Genes, Immediate-Early ,Cells, Cultured ,Regulation of gene expression ,Endothelin-1 ,Muscle, Smooth ,Smooth muscle contraction ,Middle Aged ,Endothelin 1 ,Culture Media ,Endocrinology ,Gene Expression Regulation ,Verapamil ,Endothelin receptor ,Immediate early gene ,Cell Division ,Penis ,medicine.drug - Abstract
Increases in cytosolic calcium levels trigger smooth muscle contraction while nuclear calcium increases are thought to regulate gene expression. Endothelin-1 (ET-1) affects both. The goal of these studies was to further investigate the importance of ET-1 to corporal physiology by examining its actions on proliferation and immediate early gene (IEG) expression in cultured human corporal smooth muscle cells.Early passage (1-3) smooth muscle cells were grown in culture and exposed to either phenylephrine (PE) or ET-1 in the absence and presence of serum, the ET(A) or ET(B) selective antagonist BQ123 or IRL1038, or the L-type Ca2+ channel blocker, verapamil. Cell proliferation was assessed with a hemocytometer. The effects of ET-1 on c-myc and c-fos were evaluated using Northern blot analysis. Parametric or nonparametric statistics were used as appropriate.Addition of ET-1 (100 nM) to serum-starved cultured corporal smooth muscle cells was associated with a nearly 2-fold increase in cell number, as well as 2 to 6-fold increases in c-myc and c-fos levels. Cellular proliferation was inhibited by ET(A)- or ET(B)-receptor subtype blockade with BQ123 (1 microM) or IRL1038 (1 microM), respectively, or blockade of Ca2+ channels with verapamil (10 microM). PE (3 microM) had no detectable effect on smooth muscle proliferation.Cell proliferation was mediated by activation of the ET(A) and ET(B) receptor subtypes, dependent on transmembrane Ca2+ flux, and correlated with significant increases in c-myc and c-fos mRNA levels. These studies extend previous observations to indicate the potential pleotropic actions of this peptide in the regulation of human corporal smooth muscle physiology in vivo. more...
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- 1998
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43. Results of Surgical Treatment for Abnormal Penile Curvature: Peyronie's Disease and Congenital Deviation by Modified Nesbit Plication (Tunical Shaving and Plication)
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Arnold Melman, Alexandru Benet, Jamil Rehman, and Lloyd S. Minsky
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Urology ,Penile Induration ,Congenital deviation ,medicine ,Humans ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Surgery ,Erectile dysfunction ,medicine.anatomical_structure ,Cavernous tissue ,Surgical Procedures, Operative ,Penile curvature ,medicine.symptom ,Peyronie's disease ,business ,Chordee ,Penis - Abstract
We report a modification of the Nesbit plication with partial thickness shaving instead of conventional excision of a wedge of tunica albuginea. The technique minimizes intraoperative bleeding, obviates cavernous tissue damage and improves adhesion of plicated tunical layers.Between September 1988 and September 1994, 32 patients underwent modified plication repair of chordee secondary to Peyronie's disease (26) or congenital penile deviation (6). The results were evaluated in the spring of 1996.Mean age plus or minus standard deviation was 55 +/- 8.8 years for patients with Peyronie's disease and 27 +/- 6.85 years for those with congenital penile deviation. Mean duration of Peyronie's disease was 22 +/- 9 months. Eight patients complained of erectile dysfunction and penile curvature. Plication for congenital deviation (6 patients) resulted in 100% satisfaction with the surgical result. Of the 26 men with Peyronie's disease 19 (78%) reported a good to excellent outcome. With prolonged followup (1 to 5 years) 7 patients had recurrent curvature due to progression of disease, including 5 with mild curvature who were able to have intercourse, in contrast with 2 who had severe early recurrence of deformity (more than 30 degrees) within 1 year postoperatively and underwent a second modified plication with good clinical outcome. Six of 32 patients with peyronie's disease were unable to resume satisfactory coitus with a postoperative straight penis. All 6 patients had concomitant poor erections preoperatively as shown by nocturnal peniletumescence and rigidity testing and 5 of them resumed regular intercourse with intracavernous pharmacotherapy.Long-term results of this modified plication demonstrate excellent clinical outcome with minimal morbidity. more...
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- 1997
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44. Abstract 271: A Novel Functional Role for Plasma miR-30d in Dyssynchronous Heart Failure
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Kirsty Danielson, Yonathan Melman, Bridget Simonson, Andreas Barth, Khalid Chakir, Andre Kleber, Jagmeet Singh, David Kass, and Saumya Das
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Physiology ,Cardiology and Cardiovascular Medicine - Abstract
Introduction: We have previously shown that plasma miR-30d level is an independent predictor of echocardiographic response to cardiac resynchronization therapy (CRT) in patients with dyssynchronous heart failure (DHF). We now test the hypothesis that miR-30d is dynamically regulated in cardiomyocytes (CMs) and plays a functional role in DHF. Methods: miR-30d levels were assessed in a canine model of DHF and CRT using qRT-PCR, and potential miR-30d targets were identified using a bioinformatics approach. miR-30d targets were validated in the canine model and in CMs in culture. The regulation and functional role of miR-30d was investigated in CMs in culture using microscopy, western blotting and qRT-pCR. Results: miR-30d is enriched in the coronary sinus compared to peripheral blood in human patients, suggesting a cardiac origin (n=7, p Conclusions: miR-30d is dynamically regulated in DHF and appears to play an important role in CM biology. Further insight into the role of ‘stretch’-regulated microRNAs such as miR-30d may pave the way for novel therapeutic and diagnostic strategies. more...
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- 2013
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45. 287 THE ROLE OF KCNQ POTASSIUM CHANNEL ACTIVITY IN BLADDER PHYSIOLOGY
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Yi Wang, Kelvin P. Davies, Arnold Melman, and Moses Tar
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Potassium channel activity ,business.industry ,Urology ,Medicine ,Pharmacology ,business - Published
- 2013
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46. The Correlation Between the New Rigiscan Plus Software and the Final Diagnosis in the Evaluation of Erectile Dysfunction
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Alexandru Benet, Arnold Melman, Richard G. Holcomb, and Jamil Rehman
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Sexual partner ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Physical examination ,medicine.disease ,Surgery ,Psychological evaluation ,Erectile dysfunction ,Predictive value of tests ,Ambulatory ,medicine ,Physical therapy ,Psychogenic disease ,Sexual history ,business - Abstract
Purpose: The computer generated recordings for 2 nights in 40 patients studied with the RigiScan† †Dacomed, Minneapolis, Minnesota. device were reevaluated using the new RigiScan Plus software to test its value in improving the discrimination between psychogenic and organic erectile dysfunction.Materials and Methods: Each man was evaluated for erectile dysfunction with a detailed medical and sexual history, physical examination, biothesiometry, plethysmography, 2 nights of ambulatory RigiScan monitoring and a psychological evaluation that usually included a private interview with the sexual partner. At the conclusion of evaluation each patient was broadly classified as having organic or psychogenic erectile dysfunction. The RigiScan reports were initially independently analyzed without the investigator's knowledge of the final diagnosis by determining the single best erectile event, with a minimal cutoff value of 60 percent erection for 5 minutes as necessary to be considered normal and the sum of... more...
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- 1996
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47. Forskolin: A Promising New Adjunct to Intracavernous Pharmacotherapy
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Arnold Melman, George J. Christ, Mira Valcic, and David Cahn
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Male ,Mean arterial pressure ,medicine.medical_specialty ,Urology ,chemistry.chemical_compound ,Dogs ,In vivo ,Internal medicine ,Cyclic AMP ,Pressure ,Carnivora ,Animals ,Medicine ,Alprostadil ,Prostaglandin E1 ,Forskolin ,Dose-Response Relationship, Drug ,biology ,business.industry ,Colforsin ,Fissipedia ,Hemodynamics ,Muscle, Smooth ,biology.organism_classification ,Endocrinology ,chemistry ,Mechanism of action ,lipids (amino acids, peptides, and proteins) ,medicine.symptom ,business ,Intracellular ,Penis - Abstract
To evaluate the utility of forskolin as a potentially novel intracavernous therapy.Forskolin- and prostaglandin E1 (PGE1)-induced intracorporal pressure changes were evaluated in vivo by cavernosometry performed on 2 male mongrel dogs, while systemic pressure changes were simultaneously monitored. Forskolin- and PGE1-induced intracellular cAMP accumulation was measured in vitro on homogeneous explant cultures of canine corporal smooth muscle cells.Forskolin and PGE1 elicited concentration-dependent increases in cAMP accumulation in cultured canine corporal smooth muscle cells. Forskolin and PGE1 also elicited concentration-dependent increases in both the magnitude and duration of intracorporal pressure, up to a maximum of 80 to 90% of mean arterial pressure. Furthermore, the presence of threshold concentrations of forskolin was shown to significantly augment the activity of PGE1 both in vitro (increased cAMP) and in vivo (increased pressure). Moreover, there were no detectable systemic effects following the intracorporal injection of forskolin or a mixture of forskolin and PGE1.These observations suggest that the use of forskolin, alone or in combination with other drugs that increase intracellular cAMP levels, might represent an attractive opportunity for improved and more rational development of next generation intracavernous pharmacotherapeutic agents. more...
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- 1996
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48. Report of a Multicenter Clinical Evaluation of the Dura-II Penile Prosthesis
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Mark Gladshteyn, Arnold A. Melman, Pratap K. Reddy, Peter H. Bernhard, Wilfred S. Kearse, Richard G. Holcomb, Jean H. Lewis, Alvin L. Sago, Samuel J. Peretsman, Judy O. Bolton, and Stephen M. Eppel
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medicine.medical_specialty ,Sexual functioning ,business.industry ,Urology ,medicine.medical_treatment ,Penile prosthesis ,Surgery ,Patient satisfaction ,medicine.anatomical_structure ,medicine ,Complication ,Adverse effect ,business ,Clinical evaluation ,Penis - Abstract
Purpose: Information was collected during the first 2 years of an ongoing, prospective, multi-institutional evaluation of the Dura-II [dagger] penile prosthesis. Evaluation included data on clinical outcomes and a patient satisfaction survey, and will continue for 5 years after implantation for each patient.[dagger] Dacomed Corp., Minneapolis, Minnesota.Materials and Methods: To date 196 patients have been evaluated. Surgical data, adverse events and information from satisfaction surveys are reported.Results: At a followup of 13.4 plus/minus 8.4 months postoperatively, adverse events occurred in 8.2 percent of the patients, resulting in reoperation in 5.1 percent. There have been no mechanical failures. Overall satisfaction rates were 85 percent at 3 months, 83 percent at 1 year and 91 percent at 2 years after implantation, and levels of sexual functioning were correspondingly high. A majority of patients assigned high scores to rigidity, concealability, ability to have intercourse and erection si... more...
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- 1996
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49. Endothelin-1 as a Putative Modulator of Erectile Dysfunction: I. Characteristics of Contraction of Isolated Corporal Tissue Strips
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Arnold Melman, George J. Christ, Seth E. Lerner, and Daniel C. Kim
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medicine.hormone ,medicine.medical_specialty ,Contraction (grammar) ,business.industry ,Urology ,medicine.disease ,Endothelin 1 ,Endothelins ,Endocrinology ,Erectile dysfunction ,In vivo ,Internal medicine ,Medicine ,medicine.symptom ,business ,Phenylephrine ,medicine.drug ,Hormone ,Muscle contraction - Abstract
Normal erectile physiology is heavily dependent on a delicate balance between the effects of endogenous vasoconstricting and vasorelaxing hormones on the tone of the corporal smooth muscle. Recent studies indicate that endothelin-1 (ET-1) is present and physiologically active in the human corpora. The primary goal of the present investigation was to further define the role of ET-1 in corporal physiology and to ascertain whether it might play a role in augmenting corporal tone in vivo, as reported in other vascular tissues. Thus, we conducted pharmacological studies of ET-1-induced steady-state contractions in isolated human corporal smooth muscle strips to determine if there were any detectable age- or diabetes-related alterations in ET-1-induced contractions. For statistical analysis, the patient population was divided into 2 age groups, A (less or equal to 59 years of age; = 11 patients) and B (greater or equal to 60 years of age; n = 7 patients), and further subdivided into 2 diagnostic categor... more...
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- 1995
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50. Investigative Urology
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A. Melman, George J. Christ, S.F. Fan, and Peter R. Brink
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Membrane potential ,business.industry ,Pulse (signal processing) ,Urology ,Depolarization ,Anatomy ,Organic disease ,Calcium in biology ,Pathogenesis ,Cell membrane ,medicine.anatomical_structure ,Smooth muscle ,Cell culture ,Biophysics ,Medicine ,business ,Ca channel - Abstract
Previous studies have demonstrated that cultured corporal smooth muscle cells have prominent outward K currents composed of several different K channel subtypes. The goals of the present investigation were (1) to assert the nature of these channels and to evaluate the characteristics of the most predominant of these channel subtypes, the Maxi-K + (K Ca ) channel, and (2) to compare K Ca channel behavior in cultured corporal smooth muscle cells derived from the human corpus cavernosum of two distinct patient populations. The patient population was subdivided into two broad diagnostic categories: Group 1: 4 patients without evidence of organic disease of the corpus cavernosum, 3 of whom had documented erections; and Group 2: 4 patients with organic erectile dysfunction. Consistent with previous observations, 3 different K channel subtypes were detected in both patient populations, with corresponding conductances of 180, 100 and 40 pS, respectively. The 183 pS channel was identified as the K Ca channel based on its selective permeability to K + and the fact that its open probability was modulated by both membrane potential and intracellular calcium levels. Specifically, the relative permeability of the 183 pS K Ca channel to K + , Rb + , and NH 4 + was 1.00:0.64:0.46. The channel was virtually impermeable to Na + and Li + (relative permeability more...
- Published
- 1995
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