1. BACILLARY LAYER DETACHMENT IN ACUTE VOGT–KOYANAGI–HARADA DISEASE
- Author
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Vishali Gupta, Aman Kumar, Reema Bansal, Kanika Aggarwal, Deeksha Katoch, Deeksha Sharma, Aniruddha Agarwal, and K. Bailey Freund
- Subjects
Vogt–Koyanagi–Harada disease ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Serous Retinal Detachment ,03 medical and health sciences ,0302 clinical medicine ,Optical coherence tomography ,Ophthalmology ,medicine ,External limiting membrane ,Intravenous methylprednisolone ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Fluorescein angiography ,eye diseases ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Photoreceptor inner segment - Abstract
PURPOSE To report the frequency, optical coherence tomography (OCT) findings, and visual and anatomic outcomes of patients with acute Vogt-Koyanagi-Harada disease presenting with the bacillary layer detachment (BLD) (intraretinal split at the photoreceptor inner segment myoid). METHODS This was a retrospective analysis of a consecutive series of patients with Vogt-Koyanagi-Harada disease having a minimum follow-up of 6 months. All patients had swept-source OCT, fluorescein angiography, and indocyanine green angiography performed at baseline. The characteristics of serial swept-source OCT were recorded and analyzed. RESULTS Sixty-two subjects (42 women; age: 34.2 ± 12 years) with Vogt-Koyanagi-Harada disease were included. 118 eyes (95.2%) had serous retinal detachment at presentation. 112 eyes (94.9%) showed the BLD at baseline. In 8 of 112 (7.1%) eyes with the BLD, the external limiting membrane at the anterior aspect of the BLD showed focal discontinuity. The interdigitation zone at the base of the BLD showed discontinuity in 53 of 112 (47.3%) eyes with the BLD. The ellipsoid zone could not be identified as a separate hyperreflective line at the base of the BLD in 102 of 112 eyes (91.1%). Bacillary layer detachments resolved within 3.4 ± 1.3 days after intravenous methylprednisolone therapy with improvement in the best-corrected visual acuity from 0.96 to 0.4 logarithm of the minimum angle of resolution (20/184 Snellen's equivalent) (P < 0.001). Resolution of serous retinal detachment was observed after 5.9 ± 2.6 days. CONCLUSION In eyes with acute Vogt-Koyanagi-Harada disease, the BLD is a common finding and represents a split in the photoreceptor layer at the inner segment myoid and can be differentiated from serous retinal detachment using swept-source OCT. In addition, resolution of the BLD and photoreceptor recovery can be evaluated using serial swept-source OCT.
- Published
- 2020
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