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Start Over Author "Rubba, Paolo" Publisher ovid technologies (wolters kluwer health)
21 results on '"Rubba, Paolo"'

1. Abstract 12066: The Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia

Author

Raal, Frederick J, primary, Rosenson, Robert S, additional, Reeskamp, Rens, additional, Kastelein, John J, additional, Rubba, Paolo, additional, Duell, Bart, additional, Koseki, Masahiro, additional, Stroes, Erik S, additional, Ali, Shazia, additional, Banerjee, Poulabi, additional, Chan, KuoChen, additional, Khilla, Nagwa, additional, McGinniss, Jennifer, additional, Pordy, Robert, additional, Zhang, Yi, additional, and Gaudet, Daniel, additional

Published
2021
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2. Abstract 12027: Low-Density Lipoprotein Cholesterol in Patients With Homozygous Familial Hypercholesterolemia Who Participated in Sequential Studies of Alirocumab and Evinacumab

Author

Raal, Frederick J, primary, Rosenson, Robert S, additional, Kolovou, Genovefa, additional, Harada-shiba, Mariko, additional, Mitchenko, Olena, additional, Rubba, Paolo, additional, ali, shazia, additional, Banerjee, Poulabi, additional, Khilla, Nagwa, additional, McGinniss, Jennifer, additional, pordy, robert, additional, and Blom, Dirk J, additional

Published
2021
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3. Abstract 14270: The Effect of Evinacumab on Apheresis Eligibility in Patients With Homozygous Familial Hypercholesterolemia

Author

Raal, Frederick J, primary, Rosenson, Robert S, additional, Reeskamp, Laurens F, additional, Hovingh, G. Kees, additional, Kastelein, John J, additional, Rubba, Paolo, additional, Ali, Shazia, additional, Banerjee, Poulabi, additional, Chan, Kuo-Chen, additional, Khilla, Nagwa, additional, McGinniss, Jennifer, additional, Pordy, Robert, additional, Zhang, Yi, additional, and Gaudet, Daniel, additional

Published
2020
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4. Abstract 14267: Evinacumab Lowers LDL-C in Patients With Homozygous Familial Hypercholesterolemia Irrespective of Background Lipid-lowering Medication

Author

Raal, Frederick J, primary, Rosenson, Robert S, additional, Reeskamp, Laurens F, additional, Hovingh, G. Kees, additional, Kastelein, John J, additional, Rubba, Paolo, additional, Ali, Shazia, additional, Banerjee, Poulabi, additional, Chan, Kuo-Chen, additional, Khilla, Nagwa, additional, McGinniss, Jennifer, additional, Pordy, Robert, additional, Zhang, Yi, additional, and Gaudet, Daniel, additional

Published
2020
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5. Abstract 14407: The Longer-term Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia

Author

Raal, Frederick J, primary, Rosenson, Robert S, additional, Reeskamp, Laurens F, additional, Hovingh, G. Kees, additional, Kastelein, John J, additional, Rubba, Paolo, additional, Ali, Shazia, additional, Banerjee, Poulabi, additional, Chan, Kuo-Chen, additional, Khilla, Nagwa, additional, Pordy, Robert, additional, Zhang, Yi, additional, and Gaudet, Daniel, additional

Published
2020
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8. Different Effects of Antihypertensive Regimens Based on Fosinopril or Hydrochlorothiazide With or Without Lipid Lowering by Pravastatin on Progression of Asymptomatic Carotid Atherosclerosis

Author

Zanchetti, Alberto, primary, Crepaldi, Gaetano, additional, Bond, M. Gene, additional, Gallus, Giuseppe, additional, Veglia, Fabrizio, additional, Mancia, Giuseppe, additional, Ventura, Alessandro, additional, Baggio, Giovannella, additional, Sampieri, Lorena, additional, Rubba, Paolo, additional, Sperti, Giovanni, additional, and Magni, Alberto, additional

Published
2004
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11. Site-Specific Atherosclerotic Plaques in the Carotid Arteries of Middle-Aged Women From Southern Italy

Author

Rubba, Paolo, primary, Panico, Salvatore, additional, Bond, M. Gene, additional, Covetti, Giuseppe, additional, Celentano, Egidio, additional, Iannuzzi, Arcangelo, additional, Galasso, Rocco, additional, Belisario, M. Antonietta, additional, Pastinese, Antonella, additional, Sacchetti, Lucia, additional, Mancini, Mario, additional, and Salvatore, Francesco, additional

Published
2001
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12. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima–media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study

Author

Zanchetti, Alberto, primary, Crepaldi, Gaetano, additional, Bond, M. Gene, additional, Gallus, Giuseppe V., additional, Veglia, Fabrizio, additional, Ventura, Alessandro, additional, Mancia, Giuseppe, additional, Baggio, Giovannella, additional, Sampieri, Lorena, additional, Rubba, Paolo, additional, Collatina, Stefano, additional, and Serrotti, Elio, additional

Published
2001
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14. Plasma Homocysteine as a Risk Factor for Vascular Disease

Author

GRAHAM, IAN M., primary, DALY, LESLIE E., additional, REFSUM, HELGA M., additional, ROBINSON, KILLIAN, additional, BRATTSTR??M, LARS E., additional, UELAND, PER M., additional, PALMA-REIS, ROBERTO J., additional, BOERS, GODFRIED H.J., additional, SHEAHAN, RICHARD G., additional, ISRAELSSON, B O, additional, UITERWAAL, CUNO S., additional, MELEADY, RAYMOND, additional, McMASTER, DOROTHY, additional, VERHOFF, PETRA, additional, WITTEMAN, JACQUELINE, additional, RUBBA, PAOLO, additional, BELLET, H??L??NE, additional, WAUTRECHT, JAN C., additional, DE VALK, HAROLD W., additional, SALES LUIS, ARMANDO C., additional, PARROT-ROULAUD, FRANCOISE M., additional, TAN, KOK SOON, additional, HIGGINS, ISABELLA, additional, GARCON, DANIELLE, additional, MEDRANO, MARIA JOS??, additional, CANDITO, MIRANDE, additional, EVANS, ALUN E., additional, and ANDRIA, GENEROSO, additional

Published
1998
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15. Low Circulating Folate and Vitamin B 6 Concentrations

Author

Robinson, Killian, primary, Arheart, Kristopher, additional, Refsum, Helga, additional, Brattström, Lars, additional, Boers, Godfried, additional, Ueland, Per, additional, Rubba, Paolo, additional, Palma-Reis, Roberto, additional, Meleady, Raymond, additional, Daly, Leslie, additional, Witteman, Jacqueline, additional, and Graham, Ian, additional

Published
1998
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19. Cerebral blood flow velocity and systemic vascular resistance after acute reduction of low-density lipoprotein in familial hypercholesterolemia

Author

G. Nappi, N. Scarpato, F. Faccenda, Arcangelo Iannuzzi, O. de Divitiis, S. Di Somma, Alfredo Postiglione, Mario Mancini, Agostino Gnasso, Paolo Rubba, Rubba, PAOLO OSVALDO FEDERICO, Faccenda, F, Di Somma, S, Gnasso, A, Scarpato, Nicola, Iannuzzi, A, Nappi, G, Postiglione, Alfredo, De Divitiis, O, and Mancini, M.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Blood viscosity, Blood lipids, Hemodynamics, Familial hypercholesterolemia, Hyperlipoproteinemia Type II, chemistry.chemical_compound, Internal medicine, medicine, Humans, adolescent, adult, blood, blood component removal, blood flow velocity, blood viscosity, blood/physiopathology/therapy, cerebrovascular circulation, cholesterol, female, hemofiltration, humans, hypercholesterolemia, hyperlipoproteinemia type ii, ldl, lipoproteins, male, middle aged, vascular resistance, Advanced and Specialized Nursing, business.industry, Blood flow, Middle Aged, Blood Viscosity, medicine.disease, Lipoproteins, LDL, Cholesterol, medicine.anatomical_structure, Endocrinology, Apheresis, chemistry, Cerebrovascular Circulation, Low-density lipoprotein, Blood Component Removal, Vascular resistance, Cardiology, Female, Vascular Resistance, Neurology (clinical), Hemofiltration, Cardiology and Cardiovascular Medicine, business, Blood Flow Velocity
Abstract

Low-density lipoprotein apheresis is currently used for the treatment of familial hypercholesterolemia, an inherited disorder of metabolism associated with premature development of cardiovascular disease. We wanted to evaluate cerebral blood flow velocity, cardiac output, and systemic vascular resistance in patients with familial hypercholesterolemia before and after low-density lipoprotein apheresis. Ten patients (age range, 14 to 46 years; 4 males, 6 females) with familial hypercholesterolemia (8 homozygotes, 2 heterozygotes) and 10 healthy control subjects of comparable age and sex distribution participated in the study. Low-density lipoprotein apheresis by dextran sulfate was performed in 8 patients (7 homozygotes, 1 heterozygote). Six patients (4 homozygotes, 2 heterozygotes) underwent a procedure of extracorporeal erythrocyte filtration with the same extracorporeal volume as for low-density lipoprotein apheresis, but with the exclusion of the passage of plasma through the dextran sulfate column. Cerebral blood flow velocity (transcranial Doppler), cardiac output, and systemic vascular resistance (electric bioimpedance cardiography) were determined by noninvasive techniques before and 1 day and 7 days after low-density lipoprotein apheresis or extracorporeal erythrocyte filtration. Plasma and blood viscosities were measured at the same time. Before apheresis, mean and diastolic cerebral flow velocities were abnormally low in hypercholesterolemic patients (P < .01 and P < .02 vs healthy control subjects, respectively). After apheresis, low-density lipoprotein cholesterol was lowered by 40% to 60% from baseline, and cerebral blood flow velocities (mean, systolic, and diastolic velocities) were increased (P < .01). Cardiac output, systemic vascular resistance, and viscosity values were not significantly modified. Extracorporeal erythrocyte filtration (without passage of plasma through the dextran sulfate column) did not modify serum lipids, hemodynamic parameters, or viscosity values. Low-density lipoprotein apheresis produces potentially useful hemodynamic effects. They are not adequately explained by changes in blood viscosity alone and might reflect a restoration of endothelium-mediated vasodilation, which is inhibited by high concentrations of low-density lipoprotein.

Published
1993

20. Premature development of iliac artery stenosis in asymptomatic type II hyperlipoproteinemia

Author

F. Faccenda, B. De Simone, Alfredo Postiglione, Mario Mancini, Paolo Rubba, Gabriele Riccardi, Rubba, PAOLO OSVALDO FEDERICO, Postiglione, Alfredo, DE SIMONE, Biagio, Faccenda, F, Riccardi, Gabriele, and Mancini, M.

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Arteriosclerosis, Early signs, Constriction, Pathologic, Iliac artery stenosis, Lipoproteins, VLDL, Iliac Artery, Asymptomatic, Hyperlipoproteinemia Type II, chemistry.chemical_compound, Internal medicine, Occlusion, Humans, Medicine, Triglycerides, Ultrasonography, business.industry, Liter, Cholesterol, LDL, Middle Aged, medicine.disease, Surgery, Peripheral, Femoral Artery, Radiography, Stenosis, chemistry, Low-density lipoprotein, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

There is conflicting evidence on the relationship between increased low density lipoprotein (LDL) concentration in Type II hyperlipoproteinemia and premature development of peripheral atherosclerosis of the lower limbs. We evaluated the early signs of iliac artery involvement in patients with asymptomatic Type II hyperlipoproteinemia. Of these, 23 were Type IIA, 12 were Type IIB. Thirty-five consecutive patients, ages 40 to 60 years, with asymptomatic Type II hyperlipoproteinemia (LDL cholesterol greater than or equal to 3.80 mmol/liter, 147 mg/dl) and 54 normocholesterolemic controls (plasma cholesterol less than 5.70 mmol/liter, 220.6 mg/dl) from a random sample of clinically healthy, 50-year-old men had a noninvasive examination to detect common and external iliac artery stenosis. Both Type II patients and the controls were examined by the echo-Doppler technique (Duplex Scanner III-ATL Mark V) with spectral analysis of the Doppler signals. This method is sensitive not only to severe stenosis or occlusion but also to non-flow-reducing stenosis (less than 50% narrowing of the lumen diameter) and to minor wall irregularities (1%-15% stenosis). In Type II patients, 19 of 70 limbs (27%) were abnormal as compared to 6 of 108 limbs (6%) in the controls (p less than 0.001). The premature development of an obliterating disease of the iliac arteries was demonstrated in persons asymptomatic for Type II hyperlipoproteinemia.

Published
1984

21. Calcium Antagonists and Thiazide Diuretics in the Treatment of Hypertension

Author

T. Marotta, L. A. Ferrara, Mario Mancini, Paolo Rubba, Fabrizio Pasanisi, Ferrara, LIBERATO ALDO, Pasanisi, Fabrizio, Marotta, T, Rubba, PAOLO OSVALDO FEDERICO, and Mancini, M.

Subjects
Adult, Male, medicine.medical_specialty, Nifedipine, medicine.medical_treatment, Urology, Blood Pressure, Placebo, Plasma renin activity, Renin, medicine, Humans, Thiazide, Aged, Pharmacology, business.industry, Sodium, Chlorthalidone, Middle Aged, Blood pressure, Delayed-Action Preparations, Decreased blood pressure, Hypertension, Drug Therapy, Combination, Female, Diuretic, business, Cardiology and Cardiovascular Medicine, medicine.drug
Abstract

The usefulness of the combination of nifedipine and chlorthalidone has been investigated in mild to moderate hypertensive patients (seven men, seven women; age range 39-62 years) by adding the diuretic to nifedipine monotherapy. After a 2 week washout, slow-release nifedipine 20 mg b.i.d. was given for 6 weeks, followed by addition of either chlorthalidone 25 mg (group A) or placebo (group B) q.d. for a further 6-week period. Blood pressure, heart rate, plasma renin activity, and 24-h urinary Na and K excretion were measured at baseline and at the end of each treatment period. Nifedipine decreased blood pressure in the two groups. A further significant fall was observed after chlorthalidone was added. No further change was detected after placebo in group B. Plasma renin activity after 1 h standardized walk significantly increased after combined treatment compared with baseline (3.3 +/- 1.2 to 9.4 +/- 5.3 ng/ml/h; p less than .05). No change was observed in 24 h urinary Na and K in the two groups. Venous distensibility measured by strain gauge plethysmography was slightly reduced during nifedipine monotherapy. Our data therefore suggest that chlorthalidone potentiates the antihypertensive effect of nifedipine despite an increase of renin activity.

Published
1987

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