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Background: Diminished Ovarian Reserve (DOR) is a common disease in reproductive-age women in the diagnosis and treatment of infertility. The incidence of DOR increased quickly in recent years and had became one of the most important factors that made the quality of women life decline. Gynecology and reproductive medicine professors have made great efforts to explore good treatment methods all over the world. Traditional Chinese Medicine has made some achievement in treating DOR as a kind of complementary and alternative therapy In Vitro Fertilization (IVF) in recent years, it is indispensable to propose a network meta-analysis (NMA) protocol to discuss the efficacy and safety of TCM in IVF. Methods: A literature search will be conducted in 8 electronic databases. Results: The efficacy and safety of traditional Chinese medicine in preconditioning patients with diminished ovarian reserve that would undergo In Vitro Fertilization will be evaluated. Results: The systematic review will evaluate the efficacy and safety of TCM in IVF. Conclusion: The result of this study will provide reliable evidence of the use of TCM in IVF. INPLASY registration number: INPLASY2020110062. Ethics and dissemination: This review does not require ethical approval.