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Your search keyword '"Ruprecht, Ruth M."' showing total 20 results
Start Over Author "Ruprecht, Ruth M." Publisher ovid technologies (wolters kluwer health)
20 results on '"Ruprecht, Ruth M."'

2. Anti-HIV IgM protects against mucosal SHIV transmission

Author

Gong, Siqi, primary, Tomusange, Khamis, additional, Kulkarni, Viraj, additional, Adeniji, Opeyemi S., additional, Lakhashe, Samir K., additional, Hariraju, Dinesh, additional, Strickland, Amanda, additional, Plake, Elizabeth, additional, Frost, Patrice A., additional, Ratcliffe, Sarah J., additional, Wang, Liping, additional, Lafer, Eileen M., additional, and Ruprecht, Ruth M., additional

Published
2018
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3. Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation

Author

Hofmann-Lehmann, Regina, Vlasak, Josef, Williams, Alison L, Chenine, Agnès-Laurence, McClure, Harold M, Anderson, Daniel C, O'Neil, Shawn, Ruprecht, Ruth M, University of Zurich, and Ruprecht, Ruth M

Subjects
2403 Immunology, 630 Agriculture, Retroviridae Proteins, Oncogenic, Immunology, SAIDS Vaccines, Simian Acquired Immunodeficiency Syndrome, Gene Products, env, 2725 Infectious Diseases, Prognosis, Vaccines, Attenuated, Macaca mulatta, CD4 Lymphocyte Count, Genes, nef, 10187 Department of Farm Animals, Infectious Diseases, Recurrence, Chronic Disease, 2723 Immunology and Allergy, 570 Life sciences, biology, Animals, Immunology and Allergy, Simian Immunodeficiency Virus, Viremia, Viral Fusion Proteins, Gene Deletion
Abstract

A live attenuated SIV vaccine strain, termed SIVmac239Delta3 and containing large deletions in, and the negative regulatory element, was previously shown to cause AIDS mostly in monkeys vaccinated as infants. In the present study, we demonstrate that SIVmac239Delta3 is pathogenic in most vaccinated adult monkeys, given enough time.Eleven rhesus macaques vaccinated as adults with SIVmac239Delta3 were followed for extended periods (up to 6.8 years).We found signs of immune dysregulation in all 11 adult vaccinees. All animals developed persistently inverted CD4 : CD8 T-cell ratios, seven (64%) had persistent recurrent viremia, and six (55%) had decreased CD4 T-cell counts (500 x 10 cells/l). Further signs included low CD4CD29 lymphocyte subsets, loss of anti-Gag antibodies, anemia, thrombocytopenia, wasting, and opportunistic infections. Two adult vaccinees (18%) subsequently developed AIDS. Development of chronic, recurrent viremia with plasma viral RNA loadsor = 10 copies/ml and cytoviremia was a poor prognostic sign.Our data demonstrate that with time, a live attenuated, multiply deleted SIV vaccine can cause immune dysregulation in most vaccine recipients, even in initially immune competent, healthy adults. Immune dysfunction can progress to full AIDS. However, pathogenic effects became evident only several years after vaccination. Thus, mass vaccination of humans with similarly constructed live attenuated HIV vaccines, recently suggested for countries with high HIV-1 transmission rates, seems contraindicated.

Published
2003
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6. Anti-HIV IgA isotypes

Author

Watkins, Jennifer D., primary, Sholukh, Anton M., additional, Mukhtar, Muhammad M., additional, Siddappa, Nagadenahalli B., additional, Lakhashe, Samir K., additional, Kim, Mikyung, additional, Reinherz, Ellis L., additional, Gupta, Sandeep, additional, Forthal, Donald N., additional, Sattentau, Quentin J., additional, Villinger, Francois, additional, Corti, Davide, additional, and Ruprecht, Ruth M., additional

Published
2013
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7. High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure

Author

Rasmussen, Robert A., primary, Siddappa, Nagadenahalli B., additional, Lakhashe, Samir K., additional, Watkins, Jennifer, additional, Villinger, François, additional, Ibegbu, Chris, additional, Florese, Ruth H., additional, Robert-Guroff, Marjorie, additional, Montefiori, David C., additional, Forthal, Donald N., additional, O’Connor, David, additional, and Ruprecht, Ruth M., additional

Published
2012
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13. Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques

Author

Ferrantelli, Flavia, primary, Hofmann-Lehmann, Regina, additional, Rasmussen, Robert A, additional, Wang, Tao, additional, Xu, Weidong, additional, Li, Pei-Lin, additional, Montefiori, David C, additional, Cavacini, Lisa A, additional, Katinger, Hermann, additional, Stiegler, Gabriela, additional, Anderson, Daniel C, additional, McClure, Harold M, additional, and Ruprecht, Ruth M, additional

Published
2003
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14. Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques

Author

Rasmussen, Robert A., primary, Hofmann-Lehmann, Regina, additional, Li, Pei-Lin, additional, Vlasak, Josef, additional, Schmitz, Joern E., additional, Reimann, Keith A., additional, Kuroda, Marcelo J., additional, Letvin, Norman L., additional, Montefiori, David C., additional, McClure, Harold M., additional, and Ruprecht, Ruth M., additional

Published
2002
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19. The Cronkhite-Canada Syndrome

Author

DANIEL, ERNO S., primary, LUDWIG, SHELLY L., additional, LEWIN, KLAUS J., additional, RUPRECHT, RUTH M., additional, RAJACICH, GEORGE M., additional, and SCHWABE, ARTHUR D., additional

Published
1982
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20. Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques

Author

Keith A. Reimann, Robert A. Rasmussen, Norman L. Letvin, Harold M. McClure, Ruth M. Ruprecht, Josef Vlasak, Pei-Lin Li, Regina Hofmann-Lehmann, Marcelo J. Kuroda, Joern E. Schmitz, David C. Montefiori, University of Zurich, and Ruprecht, Ruth M

Subjects
viruses, Immunology, HIV Infections, Viremia, CD8-Positive T-Lymphocytes, Antibodies, Viral, medicine.disease_cause, Lymphocyte Depletion, Virus, Neutralization Tests, medicine, Animals, Immunology and Allergy, Cytotoxic T cell, Neutralizing antibody, DNA Primers, 2403 Immunology, 630 Agriculture, Base Sequence, biology, Chimera, HIV, 2725 Infectious Diseases, Simian immunodeficiency virus, medicine.disease, Macaca mulatta, Virology, 10187 Department of Farm Animals, Disease Models, Animal, Infectious Diseases, 2723 Immunology and Allergy, biology.protein, 570 Life sciences, Simian Immunodeficiency Virus, Antibody, Viral load, CD8
Abstract

Objective To directly examine the role of CD8+ T cells in controlling viremia and disease during chronic, low-level primate immunodeficiency virus infection in DNA prime/protein boost-vaccinated macaques. Background A cohort of macaques, vaccinated with either a DNA prime/HIV-1 gp160 boost regimen or with gp160 alone was previously protected partially from sequential challenges with non-pathogenic and pathogenic strains of chimeric simian/human immunodeficiency virus (SHIV). In this study, the effect of temporary ablation of CD8+ T cells in these animals was examined. Methods Animals were treated with an anti-CD8 antibody and CD8+ T-cell levels in peripheral blood, plasma viral loads, peripheral blood mononuclear cell-associated virus levels, neutralizing antibody (nAb) titers and simian immunodeficiency virus Gag-specific CD8+ T-cell numbers were followed. Results Plasma viremia rose sharply in direct synchrony with a rapid but transient drop in CD8+ T cells. However, although levels of cell-associated virus also rose concomitantly, peak levels were much lower than those in virus-challenged, naive animals. In addition, despite a rise of pathogenic SHIV89.6P RNA levels in three animals, CD4+ T-cell counts remained unchanged. In each of these animals, neutralizing antibody titers against the pathogenic SHIV89.6P strain were high. Conclusions The results indicate that CD8+ T cells play a key role in suppressing viremia in a chronically infected host. In addition, the results suggest that in the absence of CD8+ T cells, nAb may act as an effective second line of defense by limiting both the spread of infectious virus to new target cells and CD4+ T-cell loss.

Published
2002
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