14 results on '"Sheng‐Kwei Song"'
Search Results
2. Diffusion Basis Spectrum Imaging Provides Insights Into Cervical Spondylotic Myelopathy Pathology
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Justin K, Zhang, Dinal, Jayasekera, Chunyu, Song, Jacob K, Greenberg, Saad, Javeed, Christopher F, Dibble, Jacob, Blum, Peng, Sun, Sheng-Kwei, Song, and Wilson Z, Ray
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Surgery ,Neurology (clinical) - Abstract
Diffusion basis spectrum imaging (DBSI) is a noninvasive quantitative imaging modality that may improve understanding of cervical spondylotic myelopathy (CSM) pathology through detailed evaluations of spinal cord microstructural compartments.To determine the utility of DBSI as a biomarker of CSM disease severity.A single-center prospective cohort study enrolled 50 patients with CSM and 20 controls from 2018 to 2020. All patients underwent clinical evaluation and diffusion-weighted MRI, followed by diffusion tensor imaging and DBSI analyses. Diffusion-weighted MRI metrics assessed white matter integrity by fractional anisotropy, axial diffusivity, radial diffusivity, and fiber fraction. In addition, DBSI further evaluates extra-axonal changes by isotropic restricted and nonrestricted fraction. Including an intra-axonal diffusion compartment, DBSI improves estimations of axonal injury through intra-axonal axial diffusivity. Patients were categorized into mild, moderate, and severe CSM using modified Japanese Orthopedic Association classifications. Imaging parameters were compared among patient groups using independent samples t tests and ANOVA.Twenty controls, 27 mild (modified Japanese Orthopedic Association 15-17), 12 moderate (12-14), and 11 severe (0-11) patients with CSM were enrolled. Diffusion tensor imaging and DBSI fractional anisotropy, axial diffusivity, and radial diffusivity were significantly different between control and patients with CSM (P.05). DBSI fiber fraction, restricted fraction, and nonrestricted fraction were significantly different between groups (P.01). DBSI intra-axonal axial diffusivity was lower in mild compared with moderate (mean difference [95% CI]: 1.1 [0.3-2.1], P.01) and severe (1.9 [1.3-2.4], P.001) CSM.DBSI offers granular data on white matter tract integrity in CSM that provide novel insights into disease pathology, supporting its potential utility as a biomarker of CSM disease progression.
- Published
- 2022
3. 498 Feasibility and Efficacy of Postoperative Diffusion Basis Spectrum Imaging to Evaluate Recovery After Surgery in Cervical Spondylotic Myelopathy
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Justin Zhang, Saad Javeed, Jacob K. Greenberg, Christopher Dibble, Dinal Jayasekera, Jacob Blum, Sheng-Kwei Song, and Wilson Zachary Ray
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Surgery ,Neurology (clinical) - Published
- 2023
4. 672 Diffusion Basis Spectrum Imaging Provides Insights into Cervical Spondylotic Myelopathy Pathology
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Justin Zhang, Saad Javeed, Jacob K. Greenberg, Dinal Jayasekera, Chunyu Song, Christopher Dibble, Jacob Blum, Peng Sun, Sheng-Kwei Song, and Wilson Zachary Ray
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Surgery ,Neurology (clinical) - Published
- 2023
5. 673 Utility of Diffusion Basis Spectrum Imaging in Quantifying Baseline Disease Severity and Prognosis of Cervical Spondylotic Myelopathy
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Justin Zhang, Saad Javeed, Jacob K. Greenberg, Dinal Jayasekera, Peng Sun, Jacob Blum, Christopher Dibble, Chunyu Song, Sheng-Kwei Song, and Wilson Zachary Ray
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Surgery ,Neurology (clinical) - Published
- 2023
6. 674 Diffusion Basis Spectrum Imaging Predicts Comprehensive Clinical Outcomes Following Surgery for Cervical Spondylotic Myelopathy
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Justin Zhang, Saad Javeed, Dinal Jayasekera, Jacob K. Greenberg, Christopher Dibble, Jacob Blum, Peng Sun, Sheng-Kwei Song, and Wilson Zachary Ray
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Surgery ,Neurology (clinical) - Published
- 2023
7. Magnetic Resonance Imaging Biomarker of Axon Loss Reflects Cervical Spondylotic Myelopathy Severity
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Kathryn Trinkaus, Paul Santiago, Daniel K. Riew, Peng Sun, Paul Gamble, Wilson Z. Ray, Samir Sullivan, Sheng-Kwei Song, Rory K.J. Murphy, Junqian Xu, Joanne M. Wagner, Michael P. Kelly, Yong Wang, Neill N. Wright, and Ian G. Dorward
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Adult ,Male ,medicine.medical_specialty ,Pathology ,Imaging biomarker ,Axonal loss ,Severity of Illness Index ,Article ,Spinal Cord Diseases ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Severity of illness ,medicine ,Humans ,Orthopedics and Sports Medicine ,Prospective Studies ,Axon ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Middle Aged ,Magnetic Resonance Imaging ,Axons ,Diffusion Magnetic Resonance Imaging ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,nervous system ,Cervical Vertebrae ,Cardiology ,Biomarker (medicine) ,Female ,Spondylosis ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Diffusion MRI - Abstract
STUDY DESIGN A prospective cohort study. OBJECTIVE In this study, we employed diffusion basis spectrum imaging (DBSI) to quantitatively assess axon/myelin injury, cellular inflammation, and axonal loss of cervical spondylotic myelopathy (CSM) spinal cords. SUMMARY OF BACKGROUND DATA A major shortcoming in the management of CSM is the lack of an effective diagnostic approach to stratify treatments and to predict outcomes. No current clinical diagnostic imaging approach is capable of accurately reflecting underlying spinal cord pathologies. METHODS Seven patients with mild (mJOA ≥15), five patients with moderate (14≥mJOA ≥11), and two patients with severe (mJOA
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- 2016
8. Optic Nerve Diffusion Tensor Imaging Parameters and Their Correlation With Optic Disc Topography and Disease Severity in Adult Glaucoma Patients and Controls
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Edward M. Barnett, Sidney T. Chang, Junqian Xu, Sheng-Kwei Song, Kathryn Trinkaus, Melike Pekmezci, and Stella N. Arthur
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Male ,glaucoma staging system ,medicine.medical_specialty ,genetic structures ,Optic Disk ,Clinical Sciences ,Partial volume ,Glaucoma ,Neurodegenerative ,Eye ,Ophthalmology & Optometry ,Article ,Clinical Research ,Ophthalmology ,Fractional anisotropy ,medicine ,Humans ,Prospective Studies ,Tomography ,Eye Disease and Disorders of Vision ,Retina ,business.industry ,Heidelberg retina tomography ,Neurosciences ,Optic Nerve ,Middle Aged ,diffusion tensor imaging ,medicine.disease ,eye diseases ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,Optical Coherence ,Case-Control Studies ,Neurological ,Optic nerve ,Biomedical Imaging ,Female ,sense organs ,business ,Tomography, Optical Coherence ,Diffusion MRI ,Optic disc - Abstract
PurposeTo evaluate optic nerve diffusion tensor imaging (DTI) parameters in glaucoma patients and controls, and to correlate DTI parameters with the rim area obtained with Heidelberg retina tomography (HRT) and with the severity of glaucomatous damage using the Glaucoma Staging System.DesignPilot study.MethodsTwenty-seven patients with glaucoma and 12 control subjects underwent DTI and HRT imaging. Main outcome measures included: fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity, HRT rim area, and Glaucoma Staging System stage.ResultsIn group comparison, mean diffusivity (1.33 vs. 0.91 μm/ms, P=0.0002), axial diffusivity (1.70 vs. 1.43 μm/ms, P=0.036), and radial diffusivity (1.24 vs. 0.71 μm/ms, P0.05).ConclusionsDTI may be a useful technique for detection and evaluation of glaucomatous damage in the optic nerve, particularly for patients in whom conventional imaging and perimetry are not possible. Future studies are needed to evaluate how DTI parameters change longitudinally with glaucomatous damage within the visual pathways and address cerebrospinal fluid partial volume effects in diffusion tensor quantification, especially for patients with advanced glaucoma stage.
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- 2014
9. Spinal cord tract diffusion tensor imaging reveals disability substrate in demyelinating disease
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Junqian Xu, Robert T. Naismith, Sheng-Kwei Song, Nhial T. Tutlam, Anne H. Cross, Joanne M. Wagner, Eric C. Klawiter, Peiqing Qian, Samantha Lancia, and Kathryn Trinkaus
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,Imaging biomarker ,Disability Evaluation ,Fractional anisotropy ,medicine ,Demyelinating disease ,Humans ,Aged ,Neuromyelitis optica ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Neuromyelitis Optica ,Middle Aged ,medicine.disease ,Spinal cord ,Cross-Sectional Studies ,Diffusion Tensor Imaging ,medicine.anatomical_structure ,Spinal Cord ,Female ,Neurology (clinical) ,business ,Diffusion MRI - Abstract
This study assessed the tissue integrity of major cervical cord tracts by using diffusion tensor imaging (DTI) to determine the relationship with specific clinical functions carried by those tracts.This was a cross-sectional study of 37 patients with multiple sclerosis or neuromyelitis optica with remote cervical cord disease. Finger vibratory thresholds, 25-foot timed walk (25FTW), 9-hole peg test (9HPT), and Expanded Disability Status Scale were determined. DTI covered cervical regions C1 through C6 with 17 5-mm slices (0.9 × 0.9 mm in-plane resolution). Regions of interest included posterior columns (PCs) and lateral corticospinal tracts (CSTs). Hierarchical linear mixed-effect modeling included covariates of disease subtype (multiple sclerosis vs neuromyelitis optica), disease duration, and sex.Vibration thresholds were associated with radial diffusivity (RD) and fractional anisotropy (FA) in the PCs (both p0.01), but not CSTs (RD, p = 0.29; FA, p = 0.14). RD and FA in PCs, and RD in CSTs were related to 9HPT (each p0.0001). 25FTW was associated with RD and FA in PCs (p0.0001) and RD in CSTs (p = 0.008). Expanded Disability Status Scale was related to RD and FA in PCs and CSTs (p0.0001). Moderate/severe impairments in 9HPT (p = 0.006) and 25FTW (p = 0.017) were more likely to show combined moderate/severe tissue injury within both PCs and CSTs by DTI.DTI can serve as an imaging biomarker of spinal cord tissue injury at the tract level. RD and FA demonstrate strong and consistent relationships with clinical outcomes, specific to the clinical modality.
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- 2013
10. Rituximab add-on therapy for breakthrough relapsing multiple sclerosis: A 52-week phase II trial
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Becky J. Parks, Joanne Lauber, Anne H. Cross, Sheng-Kwei Song, Jeri-Anne Lyons, Laura Piccio, Robert T. Naismith, Nhial T. Tutlam, and Kathryn Trinkaus
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medicine.medical_specialty ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Phases of clinical research ,medicine.disease ,Gastroenterology ,Surgery ,Clinical trial ,Multiple sclerosis functional composite ,Tolerability ,Internal medicine ,medicine ,Rituximab ,Neurology (clinical) ,business ,Adverse effect ,medicine.drug - Abstract
Objective: B cells and the humoral immune system have been implicated in the pathogenesis of multiple sclerosis (MS). This study sought to evaluate the efficacy, safety, and tolerability of add-on therapy with rituximab, a monoclonal antibody that depletes circulating B cells, in subjects with relapsing MS with breakthrough disease defined by clinical and MRI activity (Class III evidence). Methods: Thirty subjects with a relapse within the past 18 months despite use of an injectable disease-modifying agent, and with at least 1 gadolinium-enhancing (GdE) lesion on any of 3 pretreatment MRIs, received rituximab administered at 375 mg/m 2 weekly × 4 doses. Three monthly posttreatment brain MRI scans were obtained beginning 12 weeks after the first infusion. Multiple Sclerosis Functional Composite (MSFC) and Expanded Disability Status Scale (EDSS) were obtained at baseline and throughout the posttreatment follow-up. Results: GdE lesions were reduced after treatment with rituximab, with 74% of posttreatment MRI scans being free of GdE activity compared with 26% free of GdE activity at baseline ( p p = 0.02). EDSS remained stable. Conclusion: Rituximab add-on therapy was effective based upon blinded radiologic endpoints in this phase II study. In combination with standard injectable therapies, rituximab was well-tolerated with no serious adverse events. B-cell–modulating therapy remains a potential option for treatment of patients with relapsing MS with an inadequate response to standard injectable therapies. Classification of evidence: This study provides Class III evidence that add-on rituximab reduces gadolinium-enhancing brain lesions in multiple sclerosis.
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- 2010
11. Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis
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Robert T. Naismith, Anne H. Cross, Sheng-Kwei Song, Eric C. Klawiter, J. Shepherd, Junqian Xu, and Nhial T. Tutlam
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Adult ,Male ,medicine.medical_specialty ,Optic Neuritis ,Visual acuity ,Adolescent ,genetic structures ,media_common.quotation_subject ,Neural Conduction ,Nerve fiber layer ,Visual system ,Nerve Fibers, Myelinated ,Sensitivity and Specificity ,Retina ,Young Adult ,Optical coherence tomography ,Predictive Value of Tests ,Ophthalmology ,medicine ,Humans ,Contrast (vision) ,Visual Pathways ,Optic neuritis ,Aged ,media_common ,medicine.diagnostic_test ,Electrodiagnosis ,Electroencephalography ,Optic Nerve ,Articles ,Middle Aged ,Prognosis ,medicine.disease ,eye diseases ,Surgery ,Cross-Sectional Studies ,medicine.anatomical_structure ,Optic nerve ,Evoked Potentials, Visual ,Female ,sense organs ,Neurology (clinical) ,medicine.symptom ,Psychology ,Tomography, Optical Coherence - Abstract
Determine the utility of optical coherence tomography (OCT) to detect clinical and subclinical remote optic neuritis (ON), its relationship to clinical characteristics of ON and visual function, and whether the retinal nerve fiber layer (RNFL) thickness functions as a surrogate marker of global disease severity.Cross-sectional study of 65 subjects with at least 1 clinical ON episode at least 6 months prior. Measures included clinical characteristics, visual acuity (VA), contrast sensitivity (CS), OCT, and visual evoked potentials (VEP).Ninety-six clinically affected optic nerves were studied. The sensitivity of OCT RNFL after ON was 60%, decreasing further with mild onset and good recovery. VEP sensitivity was superior at 81% (p = 0.002). Subclinical ON in the unaffected eye was present in 32%. VEP identified 75% of all subclinically affected eyes, and OCT identified20%. RNFL thickness demonstrated linear correlations with VA (r = 0.65) and CS (r = 0.72) but was unable to distinguish visual categories20/50. RNFL was thinner with severe onset and disease recurrence but was unaffected by IV glucocorticoids. OCT measurements were not related to overall disability, ethnicity, sex, or age at onset. The greatest predictor for RNFL in the unaffected eye was the RNFL in the fellow affected eye.Visual evoked potentials (VEP) remains the preferred test for detecting clinical and subclinical optic neuritis. Optical coherence tomography (OCT) measures were unrelated to disability and demographic features predicting a worse prognosis in multiple sclerosis. OCT may provide complementary information to VEP in select cases, and remains a valuable research tool for studying optic nerve disease in populations.
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- 2009
12. IN VIVO IMAGING IN A MURINE MODEL OF GLIOBLASTOMA
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John E. Wanebo, Robert H. Mach, Michael R. Chicoine, Jason S. Lewis, Thomas A. Woolsey, Sheng-Kwei Song, Joel R. Garbow, Sarah C. Jost, Jinbin Xu, and Keith M. Rich
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Pathology ,medicine.medical_specialty ,Central nervous system disease ,Mice ,In vivo ,Cell Line, Tumor ,Glioma ,medicine ,Animals ,Tumor marker ,Mice, Inbred BALB C ,medicine.diagnostic_test ,Brain Neoplasms ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,Xenograft Model Antitumor Assays ,Disease Models, Animal ,Tumor progression ,Positron emission tomography ,Positron-Emission Tomography ,Surgery ,Neurology (clinical) ,Glioblastoma ,Nuclear medicine ,business ,Preclinical imaging - Abstract
OBJECTIVE: To use in vivo imaging methods in mice to quantify intracranial glioma growth, to correlate images and histopathological findings, to explore tumor marker specificity, to assess effects on cortical function, and to monitor effects of chemotherapy. METHODS: Mice with DBT glioma cell tumors implanted intracranially were imaged serially with a 4.7-T small-animal magnetic resonance imaging (MR1) scanner. MRI tumor volumes were measured and correlated with postmortem histological findings. Different nonspecific and specific positron emission tomography radiopharmaceuticals, [ 18 F]2 -fluoro-2-deoxy-D-glucose, [ 18 F]3 '-deoxy-3'- -fluorothymidine, or [ 11 C]RHM-1, a σ 2 -receptor ligand, were visualized with microPET (CTI-Concorde Microsystems LLC, Knoxville, TN). Intrinsic optical signals were imaged serially during contralateral whisker stimulation to study the impact of tumor growth on cortical function. Other groups of mice were imaged serially with MRI after one or two doses of the antimitotic N,N'-bis(2-chloroethyl)-N-nitrosourea(BCNU). RESULTS: MRI and histological tumor volumes were highly correlated (r 2 = 0.85). Significant binding of [ 11 C]RHM-1 was observed in growing tumors. Over time, tumors reduced and displaced (P≤ 0.001) whisker-activated intrinsic optical signals but did not change intrinsic optical signals in the contralateral hemisphere. Tumor growth was delayed 7 days after a single dose of BCNU and 18 days after two doses of BCNU. Mean tumor volume 15 days after DBT implantation was significantly smaller for treated mice (1- and 2-dose BCNU) compared with controls (P= 0.0026). CONCLUSION: Mouse MRI, positron emission tomography, and optical imaging provide quantitative and qualitative in vivo assessments of intracranial tumors that correlate directly with tumor histological findings. The combined imaging approach provides powerful multimodality assessments of tumor progression, effects on brain function, and responses to therapy.
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- 2007
13. 144 Predicting Recovery After a Spinal Cord Injury
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Sheng-Kwei Song, Wilson Z. Ray, Peng Sun, Rory K.J. Murphy, Yong Wang, Eileen Jacobs, and Paul Gamble
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Pathology ,medicine.medical_specialty ,Wallerian degeneration ,business.industry ,Cerebral peduncle ,Spinal cord ,medicine.disease ,medicine.anatomical_structure ,Corticospinal tract ,Medical imaging ,medicine ,Biomarker (medicine) ,Surgery ,Neurology (clinical) ,business ,Spectrum imaging ,Spinal cord injury - Published
- 2014
14. The Use of Magnetic Resonance Diffusion Biomarkers to Predict Functional Outcome in Mild Traumatic Brain Injury
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Sheng-Kwei Song, David L. Brody, Tammie L.S. Benzinger, Amy Lee, Christine MacDonald, Steffany Chleboun, and Sarah C. Jost
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Traumatic brain injury ,medicine ,Surgery ,Magnetic resonance imaging ,Neurology (clinical) ,Radiology ,Diffusion (business) ,business ,medicine.disease ,Outcome (game theory) - Published
- 2008
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