Search

Your search keyword '"Stephen R. Koch"' showing total 1 results
Start Over Author "Stephen R. Koch" Publisher ovid technologies (wolters kluwer health)
1 results on '"Stephen R. Koch"'

1. Oncogenic H-Ras increases glucose metabolism with an induction of glucose transporter GLUT1 and hexokinase 2 expression

Author

Daryl K. Granner, Sunday Oladapupo, Stephen R. Koch, Richard L. Printz, Craig Short, and John E. Phay

Subjects
Hexokinase, Snf3, biology, business.industry, Glucose transporter, Carbohydrate metabolism, Cell biology, chemistry.chemical_compound, Hexokinase-2, chemistry, Apoptosis, Cancer cell, biology.protein, Medicine, Surgery, GLUT1, business
Abstract

INTRODUCTION: Oncogenic Ras supports the development of cancer cells by activating pathways that stimulate growth and prevent apoptosis. Increased glucose metabolism is a hallmark of cellular transformation. The profiles of glucose transporter (GLUT) and/or hexokinase (HK) family members may be altered to more efficiently utilize glucose after mutant Ras transformation. HK1 and 2 mitochondrial localization have been associated with alterations in apoptosis sensitivities.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results