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Introduction and importance: For treatment of prosthetic valve endocarditis (PVE), redo-aortic valve replacement (AVR) is usually required. However, the recurrence of PVE continues to be a serious problem that needs a solution. Case presentation An 83-year-old woman who had undergone AVR for aortic infective endocarditis 12 years ago was diagnosed with PVE complicated with acute cerebral infarction. Urgent redo-AVR was performed. After complete removal of the prosthesis, Perceval S valve was implanted successfully. There were no postoperative neurological deteriorations, and the echocardiogram showed no recurrence of PVE. Clinical discussion Theoretically, the fewer prostheses left in the heart, the lower the risk of PVE recurrence. Conclusion In patients with PVE, redo-AVR using the Perceval valve may be a suitable option since Perceval reduces the prosthesis in the heart compared with conventional redo-AVR., Highlights • We performed a redo-aortic valve replacement (AVR) using the Perceval valve. • The patient had prosthetic valve endocarditis (PVE) and acute cerebral infarction. • Postoperative thrombocytopenia did not lead to any cerebral complications in this case. • Perceval reduces the prosthesis in the heart compared with conventional redo-AVR. • Redo-AVR using Perceval will be beneficial in controlling recurrence of PVE.