1. CD44-negative parietal-epithelial cell staining in minimal change disease: association with clinical features, response to corticosteroids and kidney outcome
- Author
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Anabel Abo, Alejandro Cruz, Alfons Segarra, Cristina Martínez, Jorge González, Álvaro Madrid, Gloria Fraga, Maria Santacana, Marisa Martin, Neus Roca, Elias Jatem, Anna Balius, Institut Català de la Salut, [Roca N] Servicio Nefrologia Pediátrica, Hospital Universitari de Vic, Universitat de Vic, Barcelona, Spain. [Jatem E] Servicio de Nefrologia, Hospital Universitari Arnau de Vilanova, Lleida, Spain. [Abo A, Santacana M] Institut de Recerca Biomèdica Dr Pifarré, Lleida, Spain. [Cruz A] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Madrid Á] Servicio de Nefrologia Pediátrica, Hospital Sant Joan de Dèu Barcelona, Barcelona, Spain. [Fraga G] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Servicio de Nefrología Pediátrica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Martinez C] Institut de Recerca Biomèdica Dr Pifarré, Lleida, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
parietal–epithelial cells ,Pathology ,medicine.medical_specialty ,Otros calificadores::/diagnóstico [Otros calificadores] ,Corticosteroides - Ús terapèutic ,CD44 staining ,Ronyons - Malalties - Diagnòstic ,Other subheadings::/diagnosis [Other subheadings] ,Medicine ,Minimal change disease ,enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::nefritis::glomerulonefritis::glomeruloesclerosis focal [ENFERMEDADES] ,Transplantation ,Kidney ,biology ,business.industry ,CD44 ,medicine.disease ,focal and segmental glomerulosclerosis ,Epithelium ,Staining ,medicine.anatomical_structure ,minimal change disease ,Nephrology ,Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Nephritis::Glomerulonephritis::Glomerulosclerosis, Focal Segmental [DISEASES] ,biology.protein ,idiopathic nephrotic syndrome ,parietal-epithelial cells ,business - Abstract
Background Activation of parietal–epithelial cells (PECs) with neo-expression of CD44 has been found to play a relevant role in the development of focal and segmental glomerulosclerosis (FSGS). The aim of this study was to analyse whether the expression of CD44 by PECs in biopsies of minimal change disease (MCD) is associated with the response to corticosteroids, with kidney outcomes and/or can be considered an early sign of FSGS. Methods This multicentric, retrospective study included paediatric and adult patients with MCD. Demographic, clinical and biochemical data were recorded, and biopsies were stained with anti-CD44 antibodies. The association between PECs, CD44 expression and the response to corticosteroids, and kidney outcomes were analysed using logistic, Kaplan–Meier and Cox regression analyses. Results A total of 54 patients were included: 35 (65%) Conclusions In patients with a light microscopy pattern of MCD, CD44-positive staining of PECs is associated with a higher prevalence of steroid resistance and worse kidney outcomes, and can be considered an early sign of FSGS.
- Published
- 2022