1. Impact of pre-admission oral anticoagulation on ischaemic stroke volume, lesion pattern, and frequency of intracranial arterial occlusion in patients with atrial fibrillation
- Author
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Heinrich J. Audebert, Matthias Endres, Ivana Galinovic, Simon Hellwig, Sophie K. Piper, Jochen B. Fiebach, Karl Georg Haeusler, Kersten Villringer, Tatiana Usnich, Christian Wollboldt, Joanna Dietzel, and Rudi Ruschmann
- Subjects
Male ,administration & dosage [Warfarin] ,medicine.medical_treatment ,Infarction ,Administration, Oral ,030204 cardiovascular system & hematology ,diagnostic imaging [Cerebral Arteries] ,Severity of Illness Index ,Brain Ischemia ,0302 clinical medicine ,methods [Magnetic Resonance Imaging] ,Interquartile range ,Germany ,Atrial Fibrillation ,drug therapy [Atrial Fibrillation] ,Prospective Studies ,etiology [Stroke] ,First episode ,Aged, 80 and over ,Atrial fibrillation ,Thrombolysis ,Stroke volume ,Magnetic Resonance Imaging ,diagnosis [Stroke] ,Stroke ,administration & dosage [Anticoagulants] ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,epidemiology [Stroke] ,prevention & control [Stroke] ,medicine.medical_specialty ,complications [Atrial Fibrillation] ,epidemiology [Atrial Fibrillation] ,epidemiology [Germany] ,Arterial Occlusive Diseases ,Lesion ,03 medical and health sciences ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,prevention & control [Arterial Occlusive Diseases] ,pathology [Cerebral Arteries] ,cardiovascular diseases ,International Normalized Ratio ,ddc:610 ,Aged ,business.industry ,Anticoagulants ,Cerebral Arteries ,Length of Stay ,medicine.disease ,Arterial occlusion ,methods [International Normalized Ratio] ,diagnosis [Arterial Occlusive Diseases] ,diagnostic imaging [Brain Ischemia] ,Warfarin ,business ,030217 neurology & neurosurgery - Abstract
Aims Therapeutic oral anticoagulation on hospital admission reduces morbidity and mortality after acute ischaemic stroke in patients with atrial fibrillation (AF). The underlying mechanism is not fully understood. In order to assess the impact of INR-level on admission on stroke volume, lesion pattern and the frequency of intracranial arterial occlusion, we analysed serial MRI measurements in AF patients suffering acute ischaemic stroke. Methods and results This subgroup analysis of the prospective '1000Plus' study included patients with acute ischaemic stroke and known AF or a first episode of AF in hospital. All patients underwent serial brain magnetic resonance imaging. Stroke patients were categorized as follows: Group1, phenprocoumon intake, international normalized ratio (INR) ≥1.7 on admission, no thrombolysis; Group2, INR
- Published
- 2018
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