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Start Over Descriptor "EXPERIENCED PATIENTS" Publisher oxford university press
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1. Comparison between rules-based human immunodeficiency virus type 1 genotype interpretations and real or virtual phenotype

Subjects
INDIVIDUALS, ANTIRETROVIRAL THERAPY, EXPERIENCED PATIENTS, LABORATORY GUIDELINES, MANAGEMENT, SUSCEPTIBILITY, HIV DRUG-RESISTANCE, FOLLOW-UP, RANDOMIZED TRIAL, RECOMMENDATIONS
Abstract

We compared 2 rules-based genotype interpretation systems and real or virtual phenotype through a retrospective analysis of a prospective trial. Genotypes were determined with VircoGEN II (VIRCO) and were interpreted with either RetroGram 1.4 or TRUGENE HIV-1 ( guidelines 3.0) or original virtual phenotype ( Virtual Phenotype; VIRCO), as available in the year 2000. Among 188 human immunodeficiency virus (HIV) type 1 isolates, overall concordance (kappa agreement) was observed for the 2 rules-based systems, whereas striking discordances were noted between them and real and virtual phenotype interpretations for stavudine, didanosine, zalcitabine, abacavir, and amprenavir (kappa

Published
2003

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