1. Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis.
- Author
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Scotton PG, Pea F, Giobbia M, Baraldo M, Vaglia A, and Furlanut M
- Subjects
- Acute Disease, Adult, Aged, Anti-Infective Agents pharmacokinetics, Anti-Infective Agents therapeutic use, Female, Humans, Male, Meningitis, Escherichia coli drug therapy, Meningitis, Meningococcal drug therapy, Meningitis, Pneumococcal drug therapy, Middle Aged, Ofloxacin pharmacokinetics, Ofloxacin therapeutic use, Anti-Infective Agents cerebrospinal fluid, Levofloxacin, Meningitis, Escherichia coli cerebrospinal fluid, Meningitis, Meningococcal cerebrospinal fluid, Meningitis, Pneumococcal cerebrospinal fluid, Ofloxacin cerebrospinal fluid
- Abstract
We have assessed levofloxacin penetration in cerebrospinal fluid (CSF) and the liquor-to-plasma ratio (C(L)/C(P)) at 2 hours after dosing in 5 patients with spontaneous acute bacterial meningitis. CSF levofloxacin concentration at 2 hours after dosing was 1.99+/-0.67 microg/mL, and the C(L)/C(P) at 2 hours after dosing was 0.34+/-0.09.
- Published
- 2001
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