1. ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients
- Author
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Cesaro, Simone, Dalianis, Tina, Rinaldo, Christine Hanssen, Koskenvuo, Minna, Pegoraro, Anna, Einsele, Hermann, Cordonnier, Catherine, Hirsch, Hans H., Akova, Murat, Aljurf, Mahmoud, Averbuch, Dina, Barnes, Rosemary, Blennow, Ola, Bochud, Pierre-Yves, Bouza, Emilio, Bretagne, Stephane, Brüggemann, Roger, Calandra, Thierry, Carratala, Jordi, Cornely, Oliver, de la Camara, Rafael, Donnelly, Peter, Drgona, Lubos, Duarte, Rafael, Engelhard, Dan, Fox, Christopher, Girmenia, Corrado, Groll, Andreas, Heldal, Dag, Helweg-Larsen, Jannick, Herbrecht, Raoul, Johnson, Elisabeth, Klyasova, Galina, Lagrou, Katrien, Lewis, Russell E., Ljungman, Per, Maertens, Johan, Mikulska, Malgorzata, Nucci, Marcio, Padoin, Christophe, Pagano, Livio, Pagliuca, Antonio, Racil, Zdenek, Ribaud, Patricia, Rizzi-Puechal, Valérie, Roilides, Emmanuel, Robin, Christine, Rovira, Montserrat, Rupp, Markus, Sanchez, Sonia, Schellongowski, Peter, Sedlacek, Peter, Sinko, Janos, Slavin, Monica, Ferreira, Isabella Sousa, Styczynski, Jan, Tissot, Frederic, Viscoli, Claudio, Ward, Katherine, Witschi, Anne-Therese, Cesaro, Simone, Dalianis, Tina, Rinaldo, Christine Hanssen, Koskenvuo, Minna, Pegoraro, Anna, Einsele, Hermann, Cordonnier, Catherine, Hirsch, Hans H., Akova, Murat, Aljurf, Mahmoud, Averbuch, Dina, Barnes, Rosemary, Blennow, Ola, Bochud, Pierre-Yve, Bouza, Emilio, Bretagne, Stephane, Brüggemann, Roger, Calandra, Thierry, Carratala, Jordi, Cornely, Oliver, de la Camara, Rafael, Donnelly, Peter, Drgona, Lubo, Duarte, Rafael, Engelhard, Dan, Fox, Christopher, Girmenia, Corrado, Groll, Andrea, Heldal, Dag, Helweg-Larsen, Jannick, Herbrecht, Raoul, Johnson, Elisabeth, Klyasova, Galina, Lagrou, Katrien, Lewis, Russell E., Ljungman, Per, Maertens, Johan, Mikulska, Malgorzata, Nucci, Marcio, Padoin, Christophe, Pagano, Livio, Pagliuca, Antonio, Racil, Zdenek, Ribaud, Patricia, Rizzi-Puechal, Valérie, Roilides, Emmanuel, Robin, Christine, Rovira, Montserrat, Rupp, Marku, Sanchez, Sonia, Schellongowski, Peter, Sedlacek, Peter, Sinko, Jano, Slavin, Monica, Ferreira, Isabella Sousa, Styczynski, Jan, Tissot, Frederic, Viscoli, Claudio, Ward, Katherine, and Witschi, Anne-Therese
- Subjects
Cystiti ,Drug resistance ,medicine.disease_cause ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,Risk Factors ,law ,Cystitis ,Pharmacology (medical) ,guidelines ,Hematopoietic Stem Cell Transplantation ,BK virus ,Infectious Diseases ,030220 oncology & carcinogenesis ,Hemorrhagic cystitis, BK virus, stem cell transplantation, guidelines ,Human ,Cidofovir ,Microbiology (medical) ,medicine.medical_specialty ,Urinary Bladder ,Viremia ,stem cell transplantation ,Polyomavirus Infection ,03 medical and health sciences ,Antibiotic resistance ,Internal medicine ,Drug Resistance, Viral ,Hemorrhagic cystitis ,medicine ,Humans ,Pharmacology ,Polyomavirus Infections ,business.industry ,Risk Factor ,Tumor Virus Infection ,Pharmacology, Pharmacology (medical), Infectious Diseases ,medicine.disease ,BK Viru ,Clinical trial ,Tumor Virus Infections ,Settore MED/15 - MALATTIE DEL SANGUE ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,chemistry ,business ,030215 immunology - Abstract
Contains fulltext : 190548.pdf (Publisher’s version ) (Closed access) Objectives: To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods: Review of English literature and evidence-based recommendations by expert consensus. Results: BKPyV-HC occurs in 8%-25% of paediatric and 7%-54% of adult recipients undergoing allogeneic HSCT. Diagnosis requires the triad of cystitis, macro-haematuria and high urine BKPyV loads >7 log10 copies/mL, and exclusion of other relevant aetiologies. BKPyV viraemia is frequent and may serve as a more specific semiquantitative follow-up marker. No randomized controlled trials are available to inform antiviral prophylaxis or treatment. However, hyper-hydration and/or bladder irrigation showed limited prophylactic value. Fluoroquinolones are not effective for prophylaxis or treatment, but rather increase antibiotic resistance. Hyperbaric oxygen or fibrin glue is marginally effective based on small case series from correspondingly equipped centres. Although cidofovir has been reported to improve and/or reduce BKPyV viraemia or viruria, the current data do not support its regular use. Conclusions: BKPyV-HC remains a disabling unmet clinical need in HSCT that requires novel approaches supported by proper clinical trials.
- Published
- 2018