1. Second generation cryoballoon ablation for atrial fibrillation in young adults
- Author
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Diego Ruggiero, Rajin Choudhury, Giacomo Mugnai, Juan-Pablo Abugattas, Arash Aryana, Darragh Moran, Pedro Brugada, Ebru Hacioglu, Ken Takarada, Carlo de Asmundis, Valentina De Regibus, Erwin Ströker, Gaetano Paparella, Hugo Enrique Coutino-Moreno, Saverio Iacopino, Gian-Battista Chierchia, Heartrhythmmanagement, Faculty of Medicine and Pharmacy, Clinical sciences, and Cardio-vascular diseases
- Subjects
Male ,Adult ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,cryoballoon ,Catheter Ablation/adverse effects ,Young patients ,030204 cardiovascular system & hematology ,Ablation ,Cryosurgery ,Pulmonary vein isolation ,Cardiac Catheters ,Pulmonary vein ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Internal medicine ,Physiology (medical) ,Atrial Fibrillation ,Atrial Fibrillation/diagnosis ,Medicine ,Humans ,risk factors ,030212 general & internal medicine ,Young adult ,Retrospective Studies ,Cryosurgery/adverse effects ,business.industry ,Pulmonary Veins/physiopathology ,Hypertrophic cardiomyopathy ,Age Factors ,Retrospective cohort study ,Atrial fibrillation ,Equipment Design ,medicine.disease ,Surgery ,Treatment Outcome ,Pulmonary Veins ,Cohort ,Catheter Ablation ,Cardiology ,Female ,business ,Complication ,Cardiology and Cardiovascular Medicine - Abstract
AIMS: Pulmonary vein isolation (PVI) has been demonstrated more effective in young patients, in which the substrate for atrial fibrillation (AF) is probably more confined to pulmonary vein potentials. The present study sought to focus on the midterm outcomes in patients under 40 years having undergone PVI with the Cryoballoon Advance because of drug resistant AF. METHODS AND RESULTS: Between June 2012 and December 2015, 57 patients having undergone Cryoballoon ablation (CB-A) below 40 years of age for AF in our centre were retrospectively analysed and considered for our analysis. All patients underwent this procedure with the 28 mm Cryoballon Advance. All 227 veins were successfully isolated without the need for additional focal tip ablation. Median follow-up was 18 ±10 months. The freedom from AF after a blanking period of 3 months was 88% in our cohort of patients younger than 40 years old. The most frequent periprocedural complication was related to the groin puncture and occurred in 2 patients. After a single procedure, the only univariate predictor of clinical recurrence was the diagnosis of hypertrophic cardiomyopathy. CONCLUSION: Young patients affected by AF can be effectively and safely treated with CB-A that grants freedom from AF in 88% of the patients at 18 months follow-up following a 3-month blanking period. All veins could be isolated with the large 28 mm Cryoballoon Advance only.
- Published
- 2018