1. Angiographical and Doppler flow-derived parameters for assessment of coronary lesion severity and its relation to the result of exercise electrocardiography
- Subjects
coronary stenosis ,BALLOON ANGIOPLASTY ,MYOCARDIAL BLOOD-FLOW ,ARTERY STENOSES ,HUMANS ,PRESSURE ,VELOCITY RESERVE ,GUIDE-WIRE ,VALIDATION ,DISEASE ,exercise electrocardiography ,intracoronary Doppler ,DISTAL ,angiography - Abstract
Aims Evaluation of angiographical and intracoronary Doppler-derived parameters of coronary stenosis severity.Methods and Results A total of 225 patients with one-vessel disease were studied before PTCA and at 6 months follow-up. Exercise electrocardiography was performed to document presence (n=157) or absence (n=138) of an ST segment shift (greater than or equal to 0.1 mV). Intracoronary blood flow velocity analysis was performed to determine the proximal/distal flow velocity ratio, the distal diastolic/systolic flow velocity ratio and coronary flow velocity reserve. Receiver operator characteristic curves were calculated to assess the predictive value of these variables compared with the exercise test. The distal coronary flow velocity reserve demonstrated the best linear correlation for both percentage diameter stenosis and minimum lumen diameter (r=0.67 and r=0.66; PConclusions The distal coronary flow velocity reserve is the best intracoronary Doppler parameter for evaluation of coronary narrowings. Angiographical estimates of coronary lesion severity and distal coronary flow velocity reserve are good and independent predictors for the assessment of functional severity of coronary stenosis, emphasizing the complementary role of these parameters for clinical decision making. (C) 2000 The European Society of Cardiology.
- Published
- 2000