1. Up-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study
- Author
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Margerita Branca, Kari Syrjänen, Luis Otávio Sarian, Luciano Serpa Hammes, Silvano Costa, Paulo Naud, Sophie Françoise Mauricette Derchain, Adhernar Longatto-Filho, Stina Syrjänen, Cecilia Roteli-Martins, Silvio Tatti, Mojca Eržen, and Universidade do Minho
- Subjects
Oncology ,Exonucleases ,Overexpression ,Biopsy ,Alphapapillomavirus ,Surrogate end points ,Inactivation ,Stratifin ,Multicenter Studies as Topic ,14-3-3 sigma ,Cervical cancer ,medicine.diagnostic_test ,virus diseases ,Epigenetic ,General Medicine ,female genital diseases and pregnancy complications ,Neoplasm Proteins ,Up-Regulation ,medicine.anatomical_structure ,Treatment Outcome ,Female ,High-risk human papillomavirus ,medicine.medical_specialty ,Longitudinal predictive values ,Cervical intraepithelial neoplasia ,Internal medicine ,medicine ,Carcinoma ,Biomarkers, Tumor ,Humans ,Cervical Intraepithelial Neoplasia ,Cervix ,Gynecology ,Disease progression ,Science & Technology ,Cell cycle control ,business.industry ,Papillomavirus Infections ,Odds ratio ,medicine.disease ,Uterine Cervical Dysplasia ,Confidence interval ,14-3-3 Proteins ,Viral outcomes ,Exoribonucleases ,Histopathology ,14-3-3σ ,business - Abstract
To assess whether the potentially high-risk (HR) human papillomavirus (HPV)-related up-regulation of 14-3-3sigma (stratifin) has implications in the outcome of HPV infections or cervical intraepithelial neoplasia (CIN) lesions, cervical biopsy specimens from 225 women in the Latin American Screening Study were analyzed for 14-3-3sigma expression using immunohistochemical analysis. We assessed its associations with CIN grade and HR HPV at baseline and value in predicting outcomes of HR-HPV infections and the development of incident CIN 1+ and CIN 2+. Expression of 14-3-3sigma increased in parallel with the lesion grade. Up-regulation was also significantly related to HR-HPV detection (P = .004; odds ratio, 2.71; 95% confidence interval, 1.37-5.35) and showed a linear relationship to HR-HPV loads (P = .003). 14-3-3sigma expression was of no value in predicting the outcomes (incident, persistent, clearance) of HR-HPV infections or incident CIN 1+ and CIN 2+. 14-3-3sigma is not inactivated in cervical carcinoma and CIN but is up-regulated on transition from CIN 2 to CIN 3. Its normal functions in controlling G(1)/S and G(2)/M checkpoints are being bypassed by HR HPV., LAMS, Latin American Screening Study, funded by European Commission, INCO-DEV contract ICA4-CT-2001-10013.
- Published
- 2010