Author: "Nnennaya Kanu" / Publisher: oxford university press - Searchworks@Jio Institute Digital Library Search Results

Author: Nnennaya Kanu, Charles Swanton, J. Przewrocka, Rachel Rosenthal, and Andrew Rowan
Subjects: business.industry, Single gene, Hematology, Computational biology, Oncology, Chromosomal Instability, Chromosome instability, Gene Targeting, Humans, CRISPR, Medicine, CRISPR-Cas Systems, business, Letter to the Editor
Published: 2020

Author: Rachel Rosenthal, Nicholas McGranahan, Nnennaya Kanu, Sergio A. Quezada, Jiri Bartek, J. Hare, Charles Swanton, Reuben S. Harris, and Subramanian Venkatesan
Subjects: 0301 basic medicine, APOBEC, Human immunodeficiency virus (HIV), Mutagenesis (molecular biology technique), Reviews, intratumour heterogeneity, HIV Infections, Drug resistance, medicine.disease_cause, Genome, 03 medical and health sciences, Neoplasms, APOBEC Deaminases, medicine, Immune Tolerance, Animals, Humans, Genetics, drug resistance, human immunodeficiency virus, business.industry, Immune escape, immune escape, Cancer, HIV, Hematology, medicine.disease, 3. Good health, Editor's Choice, 030104 developmental biology, Oncology, Mutagenesis, business
Abstract: The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.
Published: 2018

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