1. Acute postischemic seizures are associated with increased mortality and brain damage in adult mice.
- Author
-
El-Hayek YH, Wu C, Chen R, Al-Sharif AR, Huang S, Patel N, Du C, Ruff CA, Fehlings MG, Carlen PL, and Zhang L
- Subjects
- Animals, Electroencephalography, Excitatory Postsynaptic Potentials physiology, Hypoxia-Ischemia, Brain physiopathology, In Situ Nick-End Labeling, Male, Mice, Mice, Inbred C57BL, Seizures physiopathology, Hypoxia-Ischemia, Brain complications, Hypoxia-Ischemia, Brain pathology, Seizures etiology, Seizures pathology
- Abstract
Postischemic seizures are associated with worsened outcome following stroke, but the underlying pathophysiology is poorly understood. Here we examined acute seizures in adult mice following hypoxia-ischemia (HI) via combined behavioral, electrophysiological, and histological assessments. C57BL/6 mice aged 4-9 months received a permanent occlusion of the right common carotid artery and then underwent a systemic hypoxic episode. Generalized motor seizures were observed within 72 h following HI. These seizures occurred nearly exclusively in animals with extensive brain injury in the hemisphere ipsilateral to the carotid occlusion, but their generation was not associated with electroencephalographic discharges in bilateral hippocampal and neocortical recordings. Animals exhibiting these seizures had a high rate of mortality, and post-HI treatments with diazepam and phenytoin greatly suppressed these behavioral seizures and improved post-HI animal survival. Based on these data, we conclude that these seizures are a consequence of HI brain injury, contribute to worsened outcome following HI, and that they originate from deep subcortical structures.
- Published
- 2011
- Full Text
- View/download PDF