1. Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand.
- Author
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Chotivanich K, Sritabal J, Udomsangpetch R, Newton P, Stepniewska KA, Ruangveerayuth R, Looareesuwan S, Roberts DJ, and White NJ
- Subjects
- Adult, Agglutination, CD36 Antigens physiology, Erythrocytes immunology, Humans, Rosette Formation, Severity of Illness Index, Blood Platelets physiology, Erythrocyte Aggregation, Erythrocytes parasitology, Malaria, Falciparum blood
- Abstract
The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n=63), 41% of severe malaria (n=104), and 100% of cerebral malaria (n=15; P=.001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P=.01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.
- Published
- 2004
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