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1. Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma.

2. Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide.

3. Contemporary murine models in preclinical astrocytoma drug development.

4. Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis.

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