1. Stereotactic body radiotherapy for kidney cancer: a 10-year experience from a single institute.
- Author
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Yamamoto T, Kawasaki Y, Umezawa R, Kadoya N, Matsushita H, Takeda K, Ishikawa Y, Takahashi N, Suzuki Y, Takeda K, Kawabata K, Ito A, and Jingu K
- Subjects
- Disease-Free Survival, Dose-Response Relationship, Radiation, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Kidney Neoplasms diagnostic imaging, Male, Tomography, X-Ray Computed, Kidney Neoplasms radiotherapy, Radiosurgery
- Abstract
The purpose of this retrospective study was to investigate survival outcomes and irradiated tumor control (local control [LC]) and locoregional control (LRC) after stereotactic body radiotherapy (SBRT) for T1 or recurrent T1 (rT1) kidney cancer. Twenty-nine nonconsecutive patients with 30 tumors were included. SBRT doses of 70 Gy, 60 Gy or 50 Gy in 10 fractions were prescribed with a linear accelerator using daily image guidance. The Kaplan-Meier method was used to estimate time-to-event outcomes, and the log-rank test was used to compare survival curves between groups divided by each possible factor. The median follow-up periods for all patients and survivors were 57 months and 69.6 months, respectively. The five-year LC rate, LRC rate, progression-free survival (PFS) rate, disease-specific survival (DSS) rate and overall survival (OS) rate were 94%, 88%, 50%, 96% and 68%, respectively. No significant factor was related to OS and PFS. Three of 24 non-hemodialysis (HD) patients had new-onset-HD because of the progression of underlying kidney disease. Grade 3 or higher toxicities from SBRT did not occur. In conclusion, SBRT for kidney cancer provided a high rate of LC, LRC and DSS with minimal toxicities, but patient selection and indication for SBRT should be done carefully considering the relatively low OS rate., (© The Author(s) 2020. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
- Published
- 2021
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