1. L-ficolin in children with recurrent respiratory infections
- Author
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David C. Kilpatrick, A. St. Swierzko, Krzysztof Zeman, Misao Matsushita, Maciej Cedzynski, Marc Turner, Janusz Szemraj, Małgorzata Banasik, Leokadia Bak-Romaniszyn, and Anne P.M. Atkinson
- Subjects
Adolescent ,Immunology ,Collectin ,Biology ,Mannose-Binding Lectin ,Recurrence ,Lectins ,Clinical Studies ,Respiratory Hypersensitivity ,medicine ,Humans ,Immunology and Allergy ,Child ,Respiratory Tract Infections ,Mannan-binding lectin ,Respiratory tract infections ,Respiratory disease ,Infant ,Respiratory infection ,medicine.disease ,Immunity, Innate ,Complement system ,Child, Preschool ,Lectin pathway ,Ficolin - Abstract
SUMMARY The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now measured serum L-ficolin in 313 respiratory infection patients and 74 healthy control children. L-ficolin concentrations below the lower limit of the control group were found in 6% of the patients (P
- Published
- 2004
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