1. External Validation of a Pre-operative Prognostic Nomogram for Renal Cell Carcinoma in Two Patient Populations: A Retrospective Cohort Study
- Author
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Tomohiko Ichikawa, Satoshi Fukasawa, Takashi Imamoto, Takeshi Ueda, Masayuki Kobayashi, Takanobu Utsumi, Koji Kawamura, Tomokazu Sazuka, Hiroyoshi Suzuki, Atsushi Komaru, Takahito Suyama, and Naoki Nihei
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,urologic and male genital diseases ,Nephrectomy ,Cohort Studies ,Asian People ,Predictive Value of Tests ,Renal cell carcinoma ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Carcinoma, Renal Cell ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,External validation ,Retrospective cohort study ,General Medicine ,Middle Aged ,Nomogram ,Prognosis ,University hospital ,medicine.disease ,Magnetic Resonance Imaging ,Survival Analysis ,Kidney Neoplasms ,Pre operative ,Surgery ,Nomograms ,Oncology ,Preoperative Period ,Cohort ,Female ,Radiology ,Tomography, X-Ray Computed ,business - Abstract
The aim of this study was to establish the discriminating accuracy of Kanao’s pre-operative nomogram for renal cell carcinoma in predicting cause-specific survival among representative patients who underwent nephrectomy. Patients originated from two centers: Chiba University Hospital (n ¼ 151) and Chiba Cancer Center (n ¼ 91). We validated the predictive accuracy, which was assessed using Harrell’s concordance-index. The concordance-index values were 0.692 and 0.834 for Chiba University Hospital and Chiba Cancer Center, respectively, although it was 0.822 for the combined data sets. Results of external validation were different at each cohort. We constructed calibration plots of Kanao’s nomogram and confirmed the tendency at each institution. Inconsistency of results among two centers makes it difficult to reach a valid conclusion. Therefore, the predictive accuracy of Kanao’s nomogram was not settled. Clinicians need to confirm the predictive accuracy of Kanao’s nomogram and construct calibration plots when applying this nomogram to different patient populations.
- Published
- 2011
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