1. Weaving of bacterial cellulose by the Bcs secretion systems
- Author
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Axel Siroy, Petya V. Krasteva, Wiem Abidi, Lucía Torres-Sánchez, Institut Européen de Chimie et Biologie (IECB), Institut Européen de Chimie et de Biologie, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), European Project: 0757507(2008), KRASTEVA, Petya Violinova, Combinatorial Set Theory - 2008-06-01 - 2013-05-31 - 0757507 - VALID, Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), and École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SDV]Life Sciences [q-bio] ,synthase-dependent systems ,Extracellular matrix component ,Cooperativity ,Biology ,Polysaccharide ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,Bacterial Proteins ,Polysaccharides ,bacterial cellulose secretion (Bcs) ,Secretion ,Cellulose ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Bacteria ,030302 biochemistry & molecular biology ,Biofilm ,matrix exopolysaccharides ,[SDV] Life Sciences [q-bio] ,Infectious Diseases ,c-di-GMP signaling ,chemistry ,Biochemistry ,Bacterial cellulose ,Biofilms ,Biosynthetic process ,biofilm formation - Abstract
Cellulose is the most abundant biological compound on Earth and while it is the predominant building constituent of plants, it is also a key extracellular matrix component in many diverse bacterial species. While bacterial cellulose was first described in the 19th century, it was not until this last decade that a string of structural works provided insights into how the cellulose synthase BcsA, assisted by its inner-membrane partner BcsB, senses c-di-GMP to simultaneously polymerize its substrate and extrude the nascent polysaccharide across the inner bacterial membrane. It is now established that bacterial cellulose can be produced by several distinct types of cellulose secretion systems and that in addition to BcsAB, they can feature multiple accessory subunits, often indispensable for polysaccharide production. Importantly, the last years mark significant progress in our understanding not only of cellulose polymerization per se but also of the bigger picture of bacterial signaling, secretion system assembly, biofilm formation and host tissue colonization, as well as of structural and functional parallels of this dominant biosynthetic process between the bacterial and eukaryotic domains of life. Here, we review current mechanistic knowledge on bacterial cellulose secretion with focus on the structure, assembly and cooperativity of Bcs secretion system components.
- Published
- 2021