1. Genome-wide analyses of LINE–LINE-mediated nonallelic homologous recombination
- Author
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Przemyslaw Szafranski, Ian M. Campbell, Michał Startek, Tomasz Gambin, Anna Gambin, Pawel Stankiewicz, Patricia Hixson, and Chad A. Shaw
- Subjects
Genetics ,Comparative Genomic Hybridization ,DNA Copy Number Variations ,Genome, Human ,Non-allelic homologous recombination ,Retrotransposon ,Genomics ,Biology ,Polymerase Chain Reaction ,Genome ,DNA sequencing ,3. Good health ,Long interspersed nuclear element ,Chromosome Breakpoints ,Long Interspersed Nucleotide Elements ,Humans ,Human genome ,Homologous Recombination ,Algorithms ,Comparative genomic hybridization - Abstract
Nonallelic homologous recombination (NAHR), occurring between low-copy repeats (LCRs) >10 kb in size and sharing >97% DNA sequence identity, is responsible for the majority of recurrent genomic rearrangements in the human genome. Recent studies have shown that transposable elements (TEs) can also mediate recurrent deletions and translocations, indicating the features of substrates that mediate NAHR may be significantly less stringent than previously believed. Using >4 kb length and >95% sequence identity criteria, we analyzed of the genome-wide distribution of long interspersed element (LINE) retrotransposon and their potential to mediate NAHR. We identified 17 005 directly oriented LINE pairs located
- Published
- 2015