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Your search keyword '"Cimmino, Giovanni"' showing total 11 results
Start Over Author "Cimmino, Giovanni" Publisher oxford university press (oup)
11 results on '"Cimmino, Giovanni"'

8. Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1

Author

Cimmino, Giovanni, primary, Cirillo, Plinio, primary, Conte, Stefano, primary, Pellegrino, Grazia, primary, Barra, Giusi, primary, Maresca, Lucio, primary, Morello, Andrea, primary, Calì, Gaetano, primary, Loffredo, Francesco, primary, De Palma, Raffaele, primary, Arena, Giulia, primary, Sawamura, Tatsuya, primary, Ambrosio, Giuseppe, primary, and Golino, Paolo, primary

Published
2019
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9. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis

Author

Giannarelli, Chiara, primary, Cimmino, Giovanni, additional, Connolly, Thomas M., additional, Ibanez, Borja, additional, Garcia Ruiz, Josè M., additional, Alique, Matilde, additional, Zafar, M. Urooj, additional, Fuster, Valentin, additional, Feuerstein, Giora, additional, and Badimon, Juan J., additional

Published
2011
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11. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis

Author

M. Urooj Zafar, Chiara Giannarelli, Valentin Fuster, Thomas M. Connolly, Juan J. Badimon, Giovanni Cimmino, Borja Ibanez, Giora Z. Feuerstein, Josè M. Garcia Ruiz, Matilde Alique, Giannarelli, Chiara, Cimmino, Giovanni, Connolly, Thomas M., Ibanez, Borja, Garcia Ruiz, Jos M., Alique, Matilde, Zafar, M. Urooj, Fuster, Valentin, Feuerstein, Giora, and Badimon, Juan J.

Subjects
Nuclear receptor LXR, Simvastatin, Rabbit, Magnetic resonance angiography, Random Allocation, chemistry.chemical_compound, Drug Combination, Anticholesteremic Agent, Orphan Nuclear Receptor, polycyclic compounds, Aorta, Abdominal, Chemokine CCL2, Liver X Receptors, medicine.diagnostic_test, Anticholesteremic Agents, Drug Synergism, Orphan Nuclear Receptors, Plaque, Atherosclerotic, Up-Regulation, Drug Combinations, Atherosclerosi, MRI imaging, Disease Progression, lipids (amino acids, peptides, and proteins), Rabbits, Cardiology and Cardiovascular Medicine, medicine.drug, Agonist, medicine.medical_specialty, Indazoles, medicine.drug_class, Aortic Diseases, Urology, Placebo, Thromboplastin, medicine.artery, Internal medicine, medicine, Animals, Experimental model, Liver X receptor, Inflammation, Aorta, Triglyceride, Animal, business.industry, Magnetic resonance imaging, Aortic Disease, Atherosclerosis, Indazole, Endocrinology, chemistry, Cyclooxygenase 2, business, Magnetic Resonance Angiography
Abstract

Aims The aim of this study was to investigate the effects of liver X receptors (LXRs)-β preferential activation by LXR-623 (WAY-252623), a novel LXRs agonist, on plaque progression/regression in a rabbit model of advanced atherosclerosis. Methods and results Advanced atherosclerosis was induced in New Zealand White Rabbits ( n = 41). At the end of atherosclerosis induction, animals underwent a baseline magnetic resonance imaging (MRI) and were randomized to receive LXR-623 (1.5, 5, or 15 mg/kg/day), simvastatin (5 mg/kg/day), or placebo. The combination of LXR-1.5/simvastatin was also tested. After a final MRI, animals were euthanized and their aortas processed for further analysis. Simvastatin significantly reduced lesion progression (−25%; P < 0.01) in comparison with the placebo group. A similar effect was observed in the LXR-1.5 and -5 groups. A significant regression (16.5%; P < 0.01) of existing atherosclerosis was observed in the LXR-1.5/simvastatin group. Histological and molecular analysis showed plaque stabilization in the animals treated with the LXR-1.5 and -5, and LXR-1.5/simvastatin. The effects of LXR-623 were observed in the presence of a non-significant effect on total-cholesterol, low-density lipoproteins-cholesterol, and triglyceride levels. Conclusion The results of the present study show that LXR-623 significantly reduces the progression of atherosclerosis and induces plaque regression in combination with simvastatin. These observations could drive future development of novel anti-atherosclerotic therapeutic approaches.

Published
2011
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