1. mRNA Expression of Lysyl Oxidase and Matrix Metalloproteinase-12 in Mouse Skin
- Author
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Mikako Sato, Yoshihisa Takahata, Eiichiro Onitsuka, Daichi Oikawa, Yoriko Akimoto, Mitsuhiro Furuse, Yurika Mizobe, Fumiki Morimatsu, Kousuke Hamasu, and Shoichiro Tsuyama
- Subjects
Male ,Lysyl oxidase ,Biology ,Matrix metalloproteinase ,Applied Microbiology and Biotechnology ,Biochemistry ,Gene Expression Regulation, Enzymologic ,Analytical Chemistry ,Protein-Lysine 6-Oxidase ,Mice ,chemistry.chemical_compound ,Dermis ,Matrix Metalloproteinase 12 ,Gene expression ,medicine ,Animals ,RNA, Messenger ,Molecular Biology ,Skin ,Sex Characteristics ,Messenger RNA ,Oxidase test ,integumentary system ,Organic Chemistry ,General Medicine ,Molecular biology ,Circadian Rhythm ,Desmosine ,medicine.anatomical_structure ,chemistry ,Female ,Elastic fiber ,Biotechnology - Abstract
Elastic fibers in the dermis play an important role in skin elasticity. The desmosine crosslinking structure constructed of lysyl oxidase (LOX) in elastic fibers contributes to elasticity, while elastic fibers are primarily degraded by one of the matrix metalloproteinases (MMPs), MMP-12. We investigated the gender differences and diurnal variation of these enzymes. Gender-based differences in LOX mRNA expression were detected, and were significantly lower in females. In contrast, higher MMP-12 mRNA expression was observed in the light period, suggesting that elastic fibers might be degraded in the light rather than the dark period.
- Published
- 2008