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The colonization efficacies of salivaricin A (SalA)-producing Streptococcus salivarius strains 20P3 and 5 were compared when given in milk to 219 children, using either 2-day or 9-day dosing regimens. Colonization levels overall were superior for strain 5, and the 9-day dosing schedule resulted in higher levels of both initial colonization and strain persistence. The indigenous streptococcal tongue populations of 20 (10.9%) of the 189 children in the 2-day trial showed markedly increased SalA-like inhibitory activity following use of the S. salivarius-supplemented milk. All 20 of these children were found to have had relatively small (

Plasmodium falciparum typically manifests as a severe, symptomatic infection due to the high parasitemia and increased adherence of infected cells to blood vessel endothelium. However, there are case reports of asymptomatic, indolent P falciparum infections that reactivated months or years later, even though P falciparum lacks a hypnozoite form. We report a case of a 56 year old …

In a life-span study with female Han:NMRI virgin mice (300 of a fat subline, 300 of a lean subline, and 300 controls), a total of 424 mice developed 673 ovarian tumors. Half of the mice in each group were fed ad libitum, and for the other half food was restricted. Most prevalent were tubular adenomas followed by granulosa and Sertoli cell tumors. Altogether, 42 neoplasms were classified as tubular adenocarcinomas, and 21, as luteomas . The general incidence of tumors increased sharply beyond the 18th month of age. Granulosa cell tumors arose relatively early, and tubular adenocarcinomas occurred very late in life. The occurrence of ovarian tumors depended mainly on life expectancy. All animals subjected to food restriction lived longer and developed more ovarian neoplasms than those fed ad libitum.